Small Animal BioImage

小动物生物图像

• 批准号: 8933329
• 负责人: DONALD L TRUMP
• 金额: $ 7.43万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-26 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8933329
• 关键词: Animal Disease Models; Animal Model; Animals; Biological Process; Bioluminescence; Budgets; Cancer Center Support Grant; Clinical; Data Set; Detection; Diagnostic; Disease; Disease Progression; Doctor of Philosophy; Faculty; Funding; Image; Image Analysis; Imaging Techniques; Imaging technology; Instruction; Magnetic Resonance Imaging; Malignant Neoplasms; Mission; Monitor; Patients; Peer Review; Pre-Clinical Model; Proteins; Reporting; Research; Research Personnel; Resources; Roswell Park Cancer Institute; Services; Spectrum Analysis; Techniques; Technology; Therapeutic; Training; Translating; Translations; Treatment outcome; Ultrasonography; bioimaging; cost effective; experience; image visualization; imaging modality; improved; in vivo imaging; insight; member; non-invasive imaging; novel; oncology; pre-clinical; preclinical study; programs; response

The overall mission of RPCI's Small Animal Bio-Imaging Resource (SABIR) is to provide specialized services relating to the imaging of small animal models of disease. The Resource provides scientific and technical services pertaining to image acquisition, quantitative image analysis, multidimensional renderings and visualization of imaging data sets for research. The objective of SABIR is to facilitate the conduct and progress of scientific research at RPCI by: 1. Providing the necessary intellectual and physical resources relating to non-invasive in vivo imaging, 2. Developing novel preclinical imaging techniques that provide insight into various biological processes involved in cancer and enable the conduct of preclinical trials of experimental therapeutics in animal models, 3. Establishing a technology platform that would allow translation of imaging techniques evaluated in preclinical models to improve disease detection and monitoring of therapeutic response in the clinical arena. SABIR offers customized services to investigators relating to the use of state-of-the-art small animal imaging techniques including magnetic resonance imaging (MRI) and spectroscopy (MRS), fluorescent protein imaging and multispectral imaging. The Resource has recently expanded to include ultrasound (US), bioluminescence, photoacoustic, and x-ray imaging services. The Resource is led by two PhD faculty with extensive experience in small animal imaging, and is staffed by an additional 1.2 FTE resulting in a combined expenence of greater than 40 years in operating the resource. SABIR provides 24/7 access to and training in non-invasive imaging technologies to CCSG members in a cost-effective manner. First priority for use is given to peer-review-funded RPCI CCSG members; second priority to non-peerreview- funded CCSG members; third priority to non-members and academic collaborators; and last priority to external users. During the reporting period, the Small Animal Bio-Imaging Resource has served 29 members from 6 research programs, with 76% utilization by CCSG members with peer reviewed funding. CCSG support provides 12% of the overall proposed budget.

RPCI小动物生物成像资源（SABIR）的整体任务是提供专业 与疾病小动物模型成像有关的服务。资源提供了科学和 与图像获取，定量图像分析，多维渲染有关的技术服务 和成像数据集的可视化研究集。萨比尔的目的是促进行为和 RPCI科学研究的进展： 1。提供与非侵入性体内成像有关的必要的智力和物理资源， 2。开发新型的临床前成像技术，可洞悉各种生物学过程 参与癌症并实现动物实验疗法的临床前试验 模型， 3。建立一个技术平台，该平台将允许在IN中评估的成像技术翻译 临床上的临床前模型，以改善临床治疗反应的疾病检测和监测 竞技场。 Sabir为与最先进的小动物成像有关的调查人员提供定制服务 包括磁共振成像（MRI）和光谱法（MRS），荧光蛋白的技术 成像和多光谱成像。该资源最近扩展到包括超声（美国）， 生物发光，光声和X射线成像服务。该资源由两个博士教师领导 在小动物成像中的丰富经验，并配备了另外1.2 fte的人员 在运营资源方面的总费用超过40年。萨比尔（Sabir）提供24/7的访问权限和 以具有成本效益的方式对CCSG成员进行非侵入性成像技术的培训。 将使用的首要优先级用于同行评估资助的RPCI CCSG成员；非Perreview的第二个优先事项 - 资助的CCSG成员；非会员和学术合作者的第三优先事项；和最后的优先级 给外部用户。在报告期间，小动物生物成像资源已服务29 来自6个研究计划的成员，CCSG成员使用同行审查的资金76％。 CCSG支持提供了拟议预算的12％。