Pathology

病理

• 批准号: 8933330
• 负责人: DONALD L TRUMP
• 金额: $ 7.16万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-26 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8933330
• 关键词: Archives; Area; Blood; Budgets; Cancer Center Support Grant; Clinical Research; Clinical Trials; Computer software; Core Facility; Disorder by Site; Doctor of Philosophy; Equipment; Faculty; Formalin; Freezing; Funding; Guidelines; Histology; Image; Image Analysis; Immunohistochemistry; Laboratories; Lasers; Leadership; Maintenance; Management Information Systems; Microdissection; Paraffin; Paraffin Embedding; Pathology; Peer Review; Process; Quality Control; Reporting; Research; Research Personnel; Research Subjects; Resource Sharing; Resources; Role; Roswell Park Cancer Institute; Scanning; Science; Services; Solutions; Spectral Karyotyping; System; Technology; The Cancer Genome Atlas; Time; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; base; cost effective; cost effectiveness; cryostat; high standard; leukemia; macromolecule; member; programs; tissue resource

The RPCI Pathology Resource Network (PRN) Shared Resource, directed by Dr. Carl Morrison (GN), provides specialized technologies, services, and expertise involving all aspects of biospecimens through 6 integrated facilities: 1) Tissue Procurement, 2) Pathology Core Facility, 3) Paraffin Archive, 4) Special Functions Laboratory, 5) Correlative Science Pathology Office (CSPO), and 6) Leukemia Bank. This centralization of all aspects of biospecimen research provides stability, reliability, cost-effectiveness, and quality control. The PRN utilizes a state-of-the-art Laboratory Information Management System (LIMS) to effectively manage tissue resources, and maintains the highest standards of quality control. The 34 full time faculty and staff (7 staff supported by CCSG funding) in the PRN provide key services, including: tissue procurement (MD leadership and 5 staff); state-of-the-art research histology (PhD leadership and 5 staff); archive curation and maintenance of formalin fixed paraffin-embedded (FFPE) tissue (2 staff); special laboratory functions including image scanning and analysis (1 PhD leader); tissue microarray (TMA) (1 staff); laser microdissection (1 staff); macromolecule processing (1 staff); spectral karyotyping (1 PhD leader, 1 staff; biospecimen clinical trials support (RN leadership and 5 staff); leukemia banking (MD leadership, 3 staff). Some staff have roles in more than one area. The (CSPO) is new since the last CCSG submission and provides an effective solution to the need for biospecimens and correlative science in clinical research. The PRN provides tissue biospecimens to more than 25 clinical trials on an annual basis and blood to almost all interventional studies. The PRN provides centralized equipment, including: immunohistochemistry autostainers, frozen tissue cryostats, freezer alarms and management systems, Aperio image scanning ScanScope, image analysis software, Arcturus and Leica tissue microdissection platforms. All of these are managed by the sophisticated multi-million dollar LIMS. Access to tissues at RPCI is determined by the various Disease Site Research Groups (DSRGs), but the overall guidelines are set by the Tissue Utilization Committee (TUC), in accordance with CCSG guidelines. The PRN provides services to multiple peer-review funded investigators and provides major contributions to The Cancer Genome Atlas [PI: Dr. Carl Morrison (GN)]. First priority for use is given to peer-review-funded RPCI CCSG members; second priority to non-peer-review- funded CCSG members; third priority to non-members and academic collaborators; and last priority to external users. During the reporting period, the PRN shared resource has served 85 members from 6 research programs, with 48% utilization by CCSG members with peer reviewed funding. The CCSG makes up 9% of the overall proposed budget.

RPCI病理资源网络（PRN）共享资源，由Carl Morrison博士（GN）指导， 通过6个集成设施提供专业的技术，服务和专业知识，涉及生物测量的各个方面：1）组织采购，2）病理学核心设施，3）Popaffin Archive，4）特殊 功能实验室，5）相关科学病理办公室（CSPO）和6）白血病银行。这 生物循环研究各个方面的集中化提供了稳定性，可靠性，成本效益和 质量控制。 PRN利用最先进的实验室信息管理系统（LIMS）来 有效地管理组织资源，并保持质量控制的最高标准。全职34 PRN中的教职员工和教职员工（由CCSG资金支持的7名员工）提供关键服务，包括：组织 采购（MD领导力和5名员工）；最先进的研究组织学（博士领导力和5名员工）； 福尔马林固定石蜡包裹（FFPE）组织的档案策划和维护（2个工作人员）；特别的 实验室功能，包括图像扫描和分析（1位博士学位领导者）；组织微阵列（TMA）（1 职员）;激光显微解剖（1个工作人员）；大分子加工（1名人员）；光谱核分型（1博士学位 负责人，1名员工； Biospecimen临床试验支持（RN领导力和5名员工）；白血病银行（医学博士） 领导力，3名员工）。一些员工在一个以上的领域中扮演角色。 （CSPO）是新的，因为上次CCSG提交，并为需求提供了有效的解决方案 临床研究中的生物测量和相关科学。 PRN提供组织生物测量到更多 每年的临床试验超过25个临床试验，几乎所有介入研究。 PRN提供 集中设备，包括：免疫组织化学自动化器，冷冻组织低温器，冰柜警报 和管理系统，Aperio图像扫描扫描，图像分析软件，Arcturus和Leica 组织微分解平台。所有这些都是由精致的数百万美元的LIM管理的。 RPCI访问组织的访问由各种疾病部位研究组（DSRG）确定，但是 总体准则由组织利用委员会（TUC）根据CCSG指南制定。 PRN为多个同行评审资助的调查人员提供服务，并为 癌症基因组图集[PI：Carl Morrison博士（GN）]。 将使用的首要优先级用于同行评估资助的RPCI CCSG成员；非PER-REVIEW的第二个优先事项 - 资助的CCSG成员；非会员和学术合作者的第三优先事项；以及最后的优先事项 外部用户。在报告期间，PRN共享资源已为85位成员提供了6个。 研究计划，CCSG成员使用同行评估的资金有48％的利用。 CCSG制造 占整体预算的9％。