SEQUENCE DETERMINANTS OF PROTEIN STRUCTURE AND FUNCTION

蛋白质结构和功能的序列决定因素

• 批准号: 8361605
• 负责人: Robert T Sauer
• 金额: $ 0.11万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361605
• 关键词: Enzymes; Funding; Grant; National Center for Research Resources; Principal Investigator; Proteins; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; protein structure function; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are studying how AAA+ enzymes including ClpXP, HslUV, and Lon catalyze ATP-dependent denaturation and subsequent degradation of specific target proteins.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我们正在研究 AAA+ 酶（包括 ClpXP、HslUV 和 Lon）如何催化 ATP 依赖性变性以及随后特定靶蛋白的降解。