TMRNA MEDIATED TAGGING AND PROTEIN DEGRADATION

TRNA 介导的标记和蛋白质降解

• 批准号: 7955198
• 负责人: Robert T Sauer
• 金额: $ 0.25万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955198
• 关键词: Adaptor Signaling Protein; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Mediating; Molecular; Peptide Hydrolases; Research; Research Personnel; Resources; Signal Transduction; Source; United States National Institutes of Health; protein aminoacid sequence; protein degradation; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Under the auspices of this project, we are determining the mechanisms by which peptide sequences and adaptor proteins target proteins for degradation by bacterial proteases and are elucidating the molecular signals and mechanisms that regulate allosteric PDZ-proteases.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在该项目的支持下，我们正在确定肽序列和接头蛋白靶向蛋白质被细菌蛋白酶降解的机制，并阐明调节变构 PDZ 蛋白酶的分子信号和机制。