Sports Related Subconcussive Impacts in Children: MRI & Biomechanical Correlates

儿童运动相关的亚脑震荡影响：MRI

• 批准号: 8748697
• 负责人: Joseph A Maldjian
• 金额: $ 7.46万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8748697
• 关键词: 12 year old; Area; Attention; Award; Behavior assessment; Biomechanics; Biomedical Engineering; Biometry; Brain; Brain Concussion; Child; Childhood; Childhood Injury; Clinical; Cognitive; Collaborations; Collection; Control Groups; Craniocerebral Trauma; Data; Data Analyses; Data Collection; Data Set; Databases; Diffusion; Diffusion Magnetic Resonance Imaging; Elements; Enrollment; Equipment; Funding; Grant; Head; Health Sciences; Human Resources; Image; Individual; Injury; Investments; Letters; Magnetic Resonance Imaging; Manufactured football; Measures; Mediating; Metric; Monitor; Neurocognitive; Neuropsychological Tests; Parents; Participant; Recording of previous events; Research; Research Personnel; Risk; Seasons; Sports; System; Technology; Telemetry; Testing; Time; Traumatic Brain Injury; United States National Institutes of Health; Universities; Weight; Work; Youth; age group; base; clinical epidemiology; college; data acquisition; experience; forest; graduate student; high school; instrument; member; neuroimaging; neuropsychological; prevent; public health relevance; research clinical testing

DESCRIPTION (provided by applicant): Title: Sports-related sub concussive impacts in children: MRI & biomechanical correlates Football head injuries involve significant forces and can result in mild to severe traumatic brain injuries. While this has received increasing attention at the professional and collegiate levels, there is little data at the high school level and scarceif any data available for participants in the youth leagues (8-12 years old). This study will relate information about biomechanical forces experienced during a hit in youth football to neurocognitive and imaging data to determine the effects of subconcussive impacts. All elements of this study focus on the objective to increase understanding of pediatric mild Traumatic Brain Injury (mTBI). In this R03 we will investigate the biomechanical and cognitive correlates of diffusion MRI scalar measures of mTBI in children. This project leverages the investments by Wake Forest University Health Sciences which has identified, instrumented and enrolled youth football players, and funded the data collection as part of our ongoing work in this area of critical public importance. We already have acquired a very rich data set of ~30 youth players (8- 12 years old) followed over the course of an entire season (2012 football season). All players were instrumented with the Head Impact Telemetry System (HITS) for collection of real-time impact data during all practices and games. Baseline, post-season and post-concussion multimodal magnetic resonance imaging (MRI), including structural T1-weighted, and diffusion tensor and kurtosis imaging (DTI/DKI) were performed in all subjects. Neurocognitive assessments using the pediatric Immediate Post-concussion Assessment and Cognitive Testing (ImPACT) were obtained at baseline, post-injury, and post-season. Data acquisition is now continuing into the 2013 season with 30 new players already being monitored with HITs, and having all received baseline imaging and neuropsychologic testing including IMPACT testing and additional NIH toolbox measures. We have also recently been awarded internal institutional funding for acquiring a non-contact sport control data set (25 participants), including imaging and cognitive testing at baseline and post-season. This R03 will help fund a graduate student in Biomedical Engineering to assist in the MRI diffusion analyses of the acquired youth football and control data. The utilization of state-of-the-art HITs technology and the acquisition of HITs data at all practices and games provides an extremely thorough characterization of the biomechanical forces experienced by the brains of the young athletes. This unique data set represents the largest of its type in the world, combining imaging, cognitive testing and biomechanical measures in the youth age group. The long term benefit of the research will be to allow equipment designers, researchers, and clinicians to better prevent, mitigate, identify and treat injuries to help make football a safer activity for millions of children.

描述（由申请人提供）：标题：儿童与运动有关的亚脑震荡影响：MRI和生物力学相关的足球头部受伤涉及重大力量，并可能导致轻度至严重的创伤性脑损伤。虽然这受到了越来越多的关注 在专业和大学级别上，高中级的数据很少，并且稀缺了青年联赛（8-12岁）的参与者可用的任何数据。这项研究将将有关青年足球击中期间生物力学力量的信息与神经认知和成像数据联系起来，以确定亚语影响的影响。这项研究的所有元素都集中于增加对小儿轻度创伤性脑损伤（MTBI）的理解的目标。在此R03中，我们将研究儿童MTBI扩散MRI标量测量的生物力学和认知相关性。该项目利用Wake Forest University Health Sciences的投资，该科学已经确定，仪器和招募了青年足球运动员，并为数据收集提供了资金，作为我们正在进行的工作的一部分 至关重要的领域。在整个赛季（2012年足球赛季）的过程中，我们已经获得了一个非常丰富的数据集（8-12岁）。所有玩家都使用Head Impact Temetry System（HITS）进行了仪器，以收集所有实践和游戏期间的实时影响数据。在所有受试者中，都进行了基线，季后赛和脑震荡后多模式磁共振成像（MRI），包括结构性T1加权以及扩散张量和峰度成像（DTI/DKI）。在基线，伤害后和季后赛中，获得了使用小儿立即进行脑震荡评估和认知测试（影响）的神经认知评估。数据获取现在一直持续到2013赛季，已经有30名新玩家受到命中的监控，并且全部收到了基线成像和神经心理学测试，包括撞击测试和其他NIH工具箱测量。最近，我们还获得了内部机构资金，以获取非接触式运动控制数据集（25名参与者），包括在基线和季后赛时进行成像和认知测试。该R03将有助于资助生物医学工程研究生，以协助对获得的青年足球和控制数据的MRI扩散分析。最先进的命中技术的利用以及在所有实践和游戏中获取数据的数据提供了对年轻运动员大脑所经历的生物力学力量的极其彻底的表征。这个独特的数据集代表了世界上最大的类型，结合了青年年龄组的成像，认知测试和生物力学测量。研究的长期利益是允许设备设计师，研究人员和临床医生更好地预防，减轻，识别和治疗伤害，以帮助使足球成为数百万儿童的更安全活动。