Uncovering Brain Anatomy/Function/Relationships using Biologic Parametric Mapping

使用生物参数映射揭示大脑解剖结构/功能/关系

• 批准号: 7020238
• 负责人: Joseph A Maldjian
• 金额: $ 11.91万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7020238
• 关键词: Uncovering; Brain; Anatomy; Function; Relationships

DESCRIPTION (provided by candidate): The objective of this supplement is to provide a structured year of research training to a clinical resident under the mentorship of a NIBIB funded investigator. The parent grant for this supplement is composed of two components: a neuroinformatics component and a biologic component. The neuroinformatics component of the parent grant will develop multiple toolboxes including a biologic parametric mapping toolbox (BPM) for the statistical analysis of multimodal image data to be used in the current supplement. In this supplement, the BPM toolbox will be used to perform a multiple variable regression analysis to evaluate age-related relationships between functional MRI activation and structural anatomy. The overarching hypothesis for Dr. Deibler's research project is that age-related changes in grey matter volume are predictive of functional brain activity in a regionally specific manner. This analysis will control for differences in grey matter concentration. Dr. Deibler will be trained in the use of the BPM toolbox and he will implement the analyses of the data using the neuroinformatics tools from the parent project. The educational training plan proposed for Dr. Deibler has four elements: 1) development of knowledge through didactic course work in statistics, neuroscience, as well as attending journal club meetings and institutional seminars; 2) mastery of brain imaging research skills through study design, data collection, and data analyses under mentor guidance; 3) introduction to basic neurophysiologic research in the Department of Neurobiology and Anatomy at Wake Forest University; and 4) training in research ethics and medical conduct.

描述（由候选人提供）： 该补充的目的是在尼比布资助的研究者的指导下向临床居民提供结构化的研究培训年。该补充剂的父授予由两个组成部分组成：神经信息组件和生物学成分。父授予授权的神经信息学组件将开发多个工具箱，包括用于当前补充剂中要使用的多模式图像数据的统计分析的生物参数映射工具箱（BPM）。在此补充中，BPM工具箱将用于执行多变量回归分析，以评估功能性MRI激活与结构解剖结构之间的年龄相关关系。 Deibler博士研究项目的总体假设是，与年龄相关的灰质体积变化以特定于区域特定的方式预测了功能性大脑活动。该分析将控制灰质浓度的差异。 Deibler博士将接受BPM工具箱的使用培训，他将实施 使用父项目中的神经信息学工具对数据进行分析。为Deibler博士提出的教育培训计划有四个要素：1）通过统计学，神经科学的教学课程以及参加期刊俱乐部会议和机构研讨会来发展知识； 2）通过研究设计，数据收集和指导指导下的数据分析掌握大脑成像研究技能； 3）Wake Forest University神经生物学和解剖学系基本神经生理研究简介； 4）研究伦理和医疗行为的培训。