MOSAIC VACCINE-ELICITED IMMUNE RESPONSES IN RHESUS MONKEYS

马赛克疫苗在恒河猴中引起的免疫反应

• 批准号: 8357984
• 负责人: NORMAN L LETVIN
• 金额: $ 6.84万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357984
• 关键词: Antigens; CD8-Positive T-Lymphocytes; Cellular Immunity; Consensus; Development; Funding; Genes; Genetic Heterogeneity; Genetic Variation; Grant; HIV; HIV vaccine; Immune response; Macaca mulatta; National Center for Research Resources; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Solutions; Source; United States National Institutes of Health; Vaccination; Vaccines; Virus; base; cost; design; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Creation of a successful HIV vaccine will require development of an immunogen that will generate cellular immunity with sufficient cross-clade breadth to deal with the extreme genetic diversity of the virus. Recently it has been suggested that vaccines based on centralized HIV gene sequences might provide a solution to the problem posed by the genetic heterogeneity of the circulating strains of HIV. Both consensus and polyvalent mosaic immunogens are based on centralized gene sequences. The present study was designed to explore the breadth of CD4+ and CD8+ T lymphocyte responses generated by vaccination with polyvalent mosaic as compared to vaccination with consensus immunogens.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 成功研制艾滋病毒疫苗需要开发一种免疫原，该免疫原将产生具有足够跨进化枝广度的细胞免疫，以应对病毒的极端遗传多样性。最近有人提出，基于集中式 HIV 基因序列的疫苗可能会解决流行的 HIV 毒株的遗传异质性所带来的问题。 共有免疫原和多价嵌合免疫原均基于集中的基因序列。本研究旨在探讨与共识免疫原疫苗接种相比，多价嵌合体疫苗接种产生的 CD4+ 和 CD8+ T 淋巴细胞反应的广度。