RNA EXPRESSION PROFILES OF SIV-SPECIFIC CD8+ T CELLS

SIV 特异性 CD8 T 细胞的 RNA 表达谱

• 批准号: 8172906
• 负责人: NORMAN L LETVIN
• 金额: $ 6.58万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172906
• 关键词: CD8B1 gene; Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Genotype; Grant; Institution; Macaca mulatta; Mamu-A 02 antigen; Molecular Profiling; Monkeys; Plasma; Play; RNA; Research; Research Personnel; Resources; Role; Source; T-Lymphocyte; Testing; Transcript; United States National Institutes of Health; Viral Load result; Viremia; Virus

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is known that SIV-infected Mamu-A superscript 01+ rhesus macaques develop lower plasma viral loads than Mamu-A*01- monkeys. CD8+ T cells possibly play a role in the control of viremia. To test this hypothesis SIV-specific CD8+ T cells from Mamu-A*01+ (A*02-, B*17-,B*08-) monkeys and Mamu-A*02+ (A*01-, B*17-, B*08-) monkeys are being isolated. Virus-specific CD8+ T cells may be different in Mamu-A*01+ monkeys from those on Mamu-A*02+ monkeys. This difference may be reflected in the RNA transcripts that are present in the virus-specific CD8+ T cells from monkeys with different genotypes.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 已知感染 SIV 的 Mamu-A 上标 01+ 恒河猴的血浆病毒载量低于 Mamu-A*01- 猴。 CD8+ T 细胞可能在控制病毒血症中发挥作用。为了检验这一假设，来自 Mamu-A*01+ (A*02-、B*17-、B*08-) 猴子和 Mamu-A*02+ (A*01-、B*17) 的 SIV 特异性 CD8+ T 细胞-, B*08-) 猴子正在被隔离。 Mamu-A*01+ 猴中的病毒特异性 CD8+ T 细胞可能与 Mamu-A*02+ 猴中的不同。 这种差异可能反映在不同基因型猴子的病毒特异性 CD8+ T 细胞中存在的 RNA 转录本上。