RNA EXPRESSION PROFILES OF SIV-SPECIFIC CD8+ T CELLS

SIV 特异性 CD8 T 细胞的 RNA 表达谱

• 批准号: 8357985
• 负责人: NORMAN L LETVIN
• 金额: $ 6.84万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357985
• 关键词: CD8B1 gene; Funding; Genetic Transcription; Genotype; Grant; Macaca mulatta; Mamu-A 02 antigen; Monkeys; National Center for Research Resources; New England; Plasma; Play; Primates; Principal Investigator; RNA; Research; Research Infrastructure; Resources; Role; SIV; Source; T-Lymphocyte; Testing; Transcript; United States National Institutes of Health; Viral Load result; Viremia; Virus; base; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. It is known that SIV-infected Mamu-A*01+ rhesus macaques develop lower plasma viral loads than Mamu-A*01- monkeys. CD8+ T cells possibly play a role in the control of viremia. To test this hypothesis SIV-specific CD8+ T cells from Mamu-A*01+ (A*02-, B*17-,B*08-) monkeys and Mamu-A*02+ (A*01-, B*17-, B*08-) monkeys are being isolated. Virus-specific CD8+ T cells may be different in Mamu-A*01+ monkeys from those on Mamu-A*02+ monkeys. This difference may be reflected in the RNA transcripts that are present in the virus-specific CD8+ T cells from monkeys with different genotypes.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 已知感染 SIV 的 Mamu-A*01+ 恒河猴的血浆病毒载量低于 Mamu-A*01- 猴。 CD8+ T 细胞可能在控制病毒血症中发挥作用。为了检验这一假设，来自 Mamu-A*01+ (A*02-、B*17-、B*08-) 猴子和 Mamu-A*02+ (A*01-、B*17) 的 SIV 特异性 CD8+ T 细胞-, B*08-) 猴子正在被隔离。 Mamu-A*01+ 猴中的病毒特异性 CD8+ T 细胞可能与 Mamu-A*02+ 猴中的不同。 这种差异可能反映在不同基因型猴子的病毒特异性 CD8+ T 细胞中存在的 RNA 转录本上。