EFFECT OF PHTHALATES ON PRIMATE PREGNANCY

邻苯二甲酸盐对灵长类动物怀孕的影响

• 批准号: 8357275
• 负责人: BRUCE D HAMMOCK
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357275
• 关键词: Adrenal Glands; Androgens; Animal Model; California; Cells; Congenital Abnormality; Defect; Estrogens; Funding; Grant; Mammals; National Center for Research Resources; Pregnancy; Primates; Principal Investigator; Production; Research; Research Infrastructure; Resources; Rodent; Sexual Development; Source; Steroids; Testis; United States National Institutes of Health; cost; fetal; male; phthalates; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. There is clear evidence that some phthalates have a direct effect on the developing testis resulting in congenital defects in male mammals. Defects in these studies have been limited to androgen secreting target cells thus the known defects are limited to males and sexual development. However, all previous experimental studies have employed rodent animal models which do not depend upon androgen production for general support of pregnancy. In this study we hypothesize that phthalates will target the fetal primate adrenal and disrupt pregnancy by limiting the production of adrenal steroids which are essential for placental production of the estrogens of pregnancy.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 有明确证据表明，某些邻苯二甲酸盐对发育中的睾丸有直接影响，导致雄性哺乳动物先天性缺陷。这些研究中的缺陷仅限于雄激素分泌靶细胞，因此已知的缺陷仅限于男性和性发育。然而，之前所有的实验研究都采用了啮齿动物模型，这些模型不依赖于雄激素的产生来支持妊娠。在这项研究中，我们假设邻苯二甲酸盐会针对胎儿灵长类动物的肾上腺，并通过限制肾上腺类固醇的产生来扰乱妊娠，而肾上腺类固醇对于胎盘产生妊娠雌激素至关重要。