Multiplex detection array with anchored derivatization for environmental monitori

用于环境监测的具有锚定衍生化的多重检测阵列

基本信息

批准号：
8715195
负责人：
Steve Michael Savoy
金额：
$ 22.5万
依托单位：
NANOHMICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8715195
关键词：
Address Adverse effects Biological California Chemicals Collaborations Collection Column Chromatography Complex Complex Mixtures Computer software Concentration measurement Custom Data Data Collection Databases Detection Development Device Designs Devices Diagnostic Diffusion Dimensions Dose Electronics Elements Environment Environmental Health Environmental Monitoring Epidemiology Exposure to Film Gas Chromatography Gases Goals Health Hexanes Home environment Human Human Biology Indium Individual Institutes Laboratories Lead Libraries Mass Spectrum Analysis Measurement Metals Methods Mission Monitor Nanotubes Nucleic Acids Oligonucleotides Pattern Peptide Nucleic Acids Peptides Personal Satisfaction Phase Physiological Power Sources Printing Process Reading Reagent Research Safety Sampling Science Security Semiconductors Solvents Source Spottings Staging Surface System Techniques Technology Thick Time Toluene Toxic effect Transducers Universities Vacuum Work Workplace Xylene air monitoring austin base detector hazard manufacturing process metal oxide method development monitoring device multiplex detection nanoimprint lithography nanoparticle nanoscale nanowire population based professor programs protein aminoacid sequence prototype public health relevance response sensor solid state technology development tool vapor volatile organic compound

项目摘要

DESCRIPTION: Complex, multi-analyte vapor analysis is routinely achieved using laboratory tools such as gas chromatography combined with mass spectrometry (GC-MS). However, these systems are not readily configurable for compact, low- concentration, near real-time environmental tracking of vapors (e.g. a wearable data logging badge), which is a stated technology development goal of the National Institute of Environmental Health and Safety (NIEHS). To address this need, Nanohmics Inc., an early-stage technology development company (Austin, TX) is currently developing OmniScense detection technology, a low profile, vapor-phase environment analysis device for monitoring air quality and toxicity at levels that are pertinent to environmental health and safety. Prototype OmniScensor devices developed to date have been used to identify and quantify common solvents and other volatile organic compounds (VOCs) via direct electrical detection with chemiresistive metal oxide semiconductor (MOx) arrays patterned using the method of NanoImprint Lithography (NIL). This approach provides greater vapor component selectivity and quantification capabilities over a large concentration dynamic range by controlling the dimensions of the sensor element at the nanoscale. Dimensional control is not readily achieved with existing commercial MOx thin films, or with research platforms based on composite transducers (e.g. nanowires, nanotubes, metal nanoparticles and graphene). In addition to sensor feature size control, further surface derivatization will provide a means to discriminate chemically similar vapor species (e.g. nonpolar toluene, xylene and hexane), thereby enabling complex analysis across the broad set of chemical functionality ranging from highly polarizing carrier acceptors/donators to nonpolar volatile gases/organics.

描述：使用诸如气相色谱法与质谱（GC-MS）等实验室工具（GC-MS）等实验室工具常规实现复杂的多分析物蒸气分析。但是，这些系统不容易为紧凑，低浓度，接近蒸气的实时环境跟踪（例如，可穿戴的数据记录徽章）配置，这是美国国家环境健康与安全研究所（NIEHS）的技术开发目标。为了满足这一需求，早期技术开发公司Nanohmics Inc.目前正在开发全面检测技术，低调，蒸气相环境分析设备，用于监测与环境健康和安全有关的水平的空气质量和毒性。迄今为止开发的原型无机械装置已用于通过使用纳米贴构（NANOIMPRINTING术（NIL）的方法）形成的化学氧化金属氧化物半导体（MOX）阵列来识别和量化常见溶剂和其他挥发性有机化合物（VOC）（VOC）。通过控制纳米级传感器元件的尺寸，这种方法在大浓度动态范围内提供了更大的蒸气组分选择性和定量能力。现有的商业MOX薄膜或基于复合换能器的研究平台（例如纳米线，纳米管，金属纳米颗粒和石墨烯），不容易实现尺寸控制。除了传感器特征尺寸的控制外，进一步的表面衍生化还将提供一种歧视化学相似的蒸气物种（例如非极性甲苯，二甲苯和己烷）的方法，从而在整个广泛的化学功能方面启用复杂分析，范围从高度极化的载体受体/捐赠者到非光极挥发性气体/有机化。