Autophagy: Fundamentals to Disease

自噬：疾病的基础

基本信息

批准号：
8639789
负责人：
DAVID L. WOODLAND
金额：
$ 0.4万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-03-01 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8639789
关键词：
Address Aging Area Automobile Driving Autophagocytosis Cancer Biology Cardiomyopathies Cell physiology Cells Chloroquine Chronic Disease Clinical Clinical Trials Collaborations Communication Crohn&apos s disease Cytoplasm Development Disease Experimental Models Fostering Future Goals Innovative Therapy Knowledge Lipids Lysosomal Storage Diseases Malignant Neoplasms Membrane Metabolism Methodology Methods Nerve Degeneration Neurodegenerative Disorders Nutrient Organelles Outcome Pathology Pathway interactions Patients Pharmacologic Substance Physiological Play Prevention Process Proteins Recycling Research Research Personnel Role Scientist Shapes Signal Transduction Source Stress Texas Therapeutic Time Training Translations Work austin cancer therapy chemotherapy clinical practice design industry partner inhibitor/antagonist innovation insight meetings next generation pre-clinical research prevent programs protein degradation public health relevance symposium therapeutic target tool

项目摘要

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Autophagy: Fundamentals to Disease, organized by Christina H. Eng, Daniel J. Klionsky, Guido Kroemer and Li Yu. The meeting will be held in Austin, Texas from May 23-28, 2014. Autophagy is a fundamental cellular process that orchestrates the degradation of proteins, lipids and organelles during both basal and cellular or environmental stress conditions. Once thought to occur only during times of nutrient limitation, autophagy clearly plays major roles in both developmental and pathological situations. As the importance of autophagy in a variety of diseases is emerging, an in-depth knowledge of primary and alternative autophagic pathways is required to fully understand and effectively modulate it. The forefront of autophagy research will be highlighted at this meeting, from basic mechanistic insights and signaling to the role autophagy plays in multiple disease areas and prospects for therapeutic targeting. Key areas of discussion will include the source of the autophagosomal membrane, new mechanistic insights into both macroautophagy and mitophagy, and the critical roles of autophagy in normal and disease situations such as cancer, neurodegenerative diseases, Crohn's disease, lysosomal storage diseases, cardiomyopathy and aging. Examining the role of autophagy in disease will enable us to understand in contexts in which modulation of autophagy may be beneficial, and identifying the core processes that control autophagy will enable us to identify tools to modulate the pathway. This meeting will bring together a variety of investigators exploring different facets of autophagy, and their interactions will expand our knowledge of fundamental autophagic mechanisms in different contexts and their critical functions in physiological and pathological settings.

描述（由申请人提供）：请求支持Keystone研讨会会议，标题为“自噬：疾病的基本原理”，由Christina H. Eng，Daniel J. Klionsky，Guido Kroemer和Li Yu组织。该会议将于2014年5月23日至28日在德克萨斯州奥斯汀举行。自噬是一个基本的细胞过程，在基础和细胞或环境应力条件下都策划了蛋白质，脂质和细胞器的降解。一旦被认为仅在营养限制时期才发生，自噬显然在发育和病理情况下都起着重要作用。随着自噬在各种疾病中的重要性正在出现，需要对主要和替代自噬途径的深入了解才能充分理解并有效地调节它。自噬研究的最前沿将在本次会议上突出显示，从基本的机械见解和信号传导到自噬在多种疾病领域的作用以及治疗靶向的前景。 Key areas of discussion will include the source of the autophagosomal membrane, new mechanistic insights into both macroautophagy and mitophagy, and the critical roles of autophagy in normal and disease situations such as cancer, neurodegenerative diseases, Crohn's disease, lysosomal storage diseases, cardiomyopathy and aging 。检查自噬在疾病中的作用将使我们能够在自噬可能是有益的环境中理解，并且确定控制自噬的核心过程将使我们能够确定调节途径的工具。这次会议将汇集各种研究人员，探索自噬的不同方面，他们的相互作用将扩大我们对不同情况下基本自噬机制的了解及其在生理和病理环境中的关键功能。