American Society for Matrix Biology Biennial Meeting 2014

2014 年美国基质生物学学会双年会

• 批准号: 8785810
• 负责人: SUNEEL S APTE
• 金额: $ 2.8万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-13 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8785810
• 关键词: Acute; Address; Affect; American; Aneurysm; Arthritis; Basic Science; Binding; Biochemistry; Biology; Bulla; Cartilage; Cells; Cellular biology; Chronic; Clinical Research; Communities; Connective Tissue Diseases; Degenerative polyarthritis; Development; Devices; Disease; Extracellular Matrix; Fibrosis; Foundations; Funding Applicant; Gene Mutation; Genetic; Goals; Human body; Immersion Investigative Technique; Inherited; Lead; Life; Malignant Neoplasms; Mentors; Mission; Molecular Biology; Muscular Dystrophies; Musculoskeletal System; Neoplasm Metastasis; Osteoporosis; Pathology; Phosphorylation; Postdoctoral Fellow; Process; Receptor Gene; Research; Scientist; Signal Transduction; Skin; Societies; Tendon structure; Tissue Engineering; Tissues; Training; Translational Research; United States National Institutes of Health; Woman; Wound Healing; base; body system; bone; graduate student; human disease; medical specialties; meetings; programs; public health relevance; single molecule; skeletal dysplasia; skin disorder; symposium; tissue repair

DESCRIPTION (provided by applicant): Funding is requested in partial support of the 7th Biennial Conference of the American Society for Matrix Biology (ASMB), which is to be held from Oct. 12-15, 2014, in Cleveland, OH (ASMB2014). ASMB is a national society whose mission is to promote basic, translational, and clinical research on the extracellular matrix (ECM), cell-ECM interactions, and ECM-based therapies and devices, and to support professional development of the matrix biology research community. Its biennial conference provides an in-depth forum integrating new information on the genetics, molecular biology, biochemistry, pathobiology, and translational relevance of all aspects of ECM. Additionally, this conference provides a continuum with cell biology and intracellular signaling via an emphasis on cell-ECM interactions and ECM-driven signaling. This all-encompassing, matrix-immersion aspect of the ASMB conference is lacking in large society conferences and is distinct from the single molecule- or process-focused conferences available to the ECM community, including Gordon, Keystone and FASEB conferences. ECM and matrix receptor gene mutations lead to inherited connective tissue disorders, skeletal dysplasias, muscular dystrophies and blistering skin diseases, and ECM dysregulation is universally a major factor in acquired diseases, both acute and chronic, affecting all organ systems. ECM is especially relevant to skin and the musculoskeletal system, where it is a primary component of bone, cartilage and tendons. Among acquired conditions, the pathology of osteoarthritis, osteoporosis, aneurysms, cancer and metastasis involves ECM destruction, and all fibrotic conditions and aberrant wound healing feature an excess or dysregulated ECM. ASMB2014 has considerable translational relevance, especially to tissue repair and engineering, and provides the basic science foundation upon which to advance these fields. The ASMB Conference brings together scientists, clinician-scientists, post-doctoral trainees, and graduate students from diverse research fields and medical specialties to discuss the most recent advances in ECM biology and their relevance to human disease. The exciting 3-day program comprises a keynote address on protein phosphorylation by Dr. Jack Dixon, five plenary sessions and 18 concurrent sessions on focused topics that provide many opportunities for short talks by trainees. In addition to advancement of the matrix biology field, ASMB2014 demonstrates a commitment to providing opportunities for in-training and women matrix biologists and has specific mentoring components. These goals and activities of ASMB2014 are fully consistent with the mission of NIH and the intent of the R13 mechanism.

描述（由申请人提供）：请求资助部分支持美国基质生物学学会 (ASMB) 第七届双年度会议，该会议将于 2014 年 10 月 12 日至 15 日在俄亥俄州克利夫兰举行 (ASMB2014) 。 ASMB 是一个国家学会，其使命是促进细胞外基质 (ECM)、细胞-ECM 相互作用以及基于 ECM 的疗法和设备的基础、转化和临床研究，并支持基质生物学研究界的专业发展。它每两年一次的会议提供了一个深入的论坛，整合了有关 ECM 各个方面的遗传学、分子生物学、生物化学、病理学和转化相关性的新信息。此外，本次会议通过强调细胞-ECM 相互作用和 ECM 驱动的信号传导，提供了细胞生物学和细胞内信号传导的连续体。 ASMB 会议的这种包罗万象、矩阵浸入式的特点是大型学会会议所缺乏的，并且与 ECM 界可用的以单分子或过程为中心的会议（包括 Gordon、Keystone 和 FASEB 会议）不同。 ECM和基质受体基因突变会导致遗传性结缔组织疾病、骨骼发育不良、肌肉营养不良和水疱性皮肤病，而ECM失调通常是影响所有器官系统的急性和慢性获得性疾病的主要因素。 ECM 与皮肤和肌肉骨骼系统尤其相关，它是骨骼、软骨和肌腱的主要组成部分。在获得性病症中，骨关节炎、骨质疏松症、动脉瘤、癌症和转移的病理学涉及 ECM 破坏，所有纤维化病症和异常伤口愈合都以 ECM 过度或失调为特征。 ASMB2014 具有相当大的转化相关性，特别是在组织修复和工程方面，并为推进这些领域提供了基础科学基础。 ASMB 会议汇集了来自不同研究领域和医学专业的科学家、临床科学家、博士后实习生和研究生，讨论 ECM 生物学的最新进展及其与人类疾病的相关性。为期 3 天的激动人心的课程包括 Jack Dixon 博士关于蛋白质磷酸化的主题演讲、五场全体会议和 18 场针对重点主题的同期会议，为学员提供了许多简短演讲的机会。除了促进基质生物学领域的发展之外，ASMB2014 还承诺为培训中的基质生物学家和女性基质生物学家提供机会，并具有特定的指导内容。 ASMB2014的这些目标和活动与NIH的使命和R13机制的意图完全一致。