PREVENTION APPROACH TO COLLEGE HEAVY DRINKING BASED ON A LOW RESPONSE TO ALCOHOL

基于对酒精反应低的大学酗酒预防方法

基本信息

批准号：
8606726
负责人：
Marc A Schuckit
金额：
$ 43.28万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-02-01 至 2016-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8606726
关键词：
Address Administrator Alcohol abuse Alcohol consumption Alcohols Attitude Behavior Belief Characteristics Data Demography Educational process of instructing Effectiveness Elements Emotional Equilibrium Exposure to Focus Groups Future Heavy Drinking High Prevalence Impulsivity Individual Institutes Internet Intervention Knowledge Link Measures Mediating Mediator of activation protein Methods Modeling Moods Morbidity - disease rate National Institute on Alcohol Abuse and Alcoholism Outcome Pattern Phenotype Pilot Projects Population Predisposition Prevention Prevention Protocols Prevention approach Prevention program Procedures Protocols documentation Questionnaires Randomized Recording of previous events Recruitment Activity Relative (related person)Research Risk Risk Factors Stress Structure Students Study Subject Surveys Techniques Testing Time Universities Videotape Visual Aid Work alcohol effect alcohol related problem alcohol response alcohol sensitivity base college college drinking comparison group cost design drinking expectation follow-up group intervention improved interest member mortality novel novel strategies peer prevent programs public health relevance response student drinking

项目摘要

DESCRIPTION (provided by applicant): This revised application evaluates a new approach to decrease heavy drinking and alcohol problems among drinking university students by addressing an individual's specific vulnerability toward these difficulties. We build upon a successful pilot protocol that focused on a relatively prevalent preexisting risk factor for heavy drinking, the low level of response (LR) to alcohol, to diminish the vulnerability toward heavy drinking related to this genetically-influenced need for a higher number of drinks to feel effects. By incorporating existing methods to create a novel and potentially more effective approach, we optimize our ability to compare results to existing state-of-the-art (SOTA) programs, and can use elements of interventions with which university administrators are already familiar and can be instituted at little cost. The proposal is the next logical step from the small pilot project described in A.6213 to determine if the prior positive outcomes remain with a larger population and a 1-yr follow-up, thus setting the potential basis for a more definitive study in the future. questionnaire will be distributed to >4,000 freshmen at UCSD to gather their demography, alcohol histories, and LR. The latter is measured by the retrospective SRE questionnaire where LR is the number of drinks required for a range of effects. Subjects matched on drinking histories will be randomly assigned to: 1) a Low Response-Based Intervention Group (LRB, N=200) where they receive five 45-min. Internet-based videotapes that incorporate the SOTA drinking intervention techniques, but with information structured around the model demonstrating how a low LR to alcohol contributes to later heavy drinking and alcohol problems; 2) a SOTA Group (N=200) where they receive similar state-of-the-art information, but are not taught about LR; or 3) a comparison Assessment Only (AO) Group (N=100) where they receive neither LRB nor SOTA-based information, but will be evaluated on the same time frame as the 2 intervention groups. All subjects will be followed for 12 months. As supported by the pilot data in A.6, Hypothesis 1 is that individuals with lower LRs to alcohol will demonstrate the greatest decreases in heavy drinking and subsequent problems when participating in the LRB Group that focuses on their specific vulnerability. Hypothesis 2 is that those with high LR (while also decreasing heavy drinking in the LRB Group) will show the greatest decreases in a SOTA Group that addresses their vulnerability that is not related to LR, but to impulsivity, mood dysregulation, and other risk factors.11 Hypothesis 3 is that the interventions incorporated in LRB and SOTA protocols will be associated with less future heavy drinking and alcohol problems than are seen in the AO Group. If the hypotheses prove correct, the results may serve as an example of how universities might improve drinking outcomes by tailoring prevention efforts to additional specific preexisting risk factors.

描述（由申请人提供）：这项修订后的申请评估了一种新的方法，可以通过解决个人在这些困难方面的特定脆弱性来减少饮酒的学生中的大量饮酒和酒精问题。我们以成功的试点协议为基础，该协议的重点是相对普遍的重量饮酒危险因素，对酒精的低水平反应（LR），以减少与这种遗传影响的饮酒相关的大量饮酒的脆弱性，从而对更高的饮料产生影响。通过合并现有的方法来创建一种新颖而可能更有效的方法，我们优化了将结果与现有最新计划（SOTA）程序进行比较的能力，并可以使用已经熟悉的大学管理员的干预措施的要素，并且几乎无法以成本进行成本。该提案是A.6213中描述的小型试点项目的下一个逻辑步骤，以确定先前的积极结果是否保留在较大的人群和1年的随访中，从而为未来更确定的研究树立了潜在的基础。问卷将分发给UCSD的4,000名新生，以收集他们的人口统计学，酒精历史和LR。后者通过回顾性SRE问卷来衡量，其中LR是一系列效果所需的饮料数量。与饮酒历史相匹配的受试者将随机分配给：1）基于响应的低响应干预组（LRB，n = 200），在那里他们获得了五个45分钟。基于Internet的录像带融合了SOTA饮酒干预技术，但围绕模型构成的信息表明，低LR对酒精的饮酒如何有助于以后的大量饮酒和酒精问题； 2）SOTA组（n = 200），他们收到类似的最新信息，但没有教授有关LR的知识；或3）仅一个比较评估（AO）组（n = 100），他们既不接收LRB也不接受基于SOTA的信息，但将与2个干预组相同的时间范围进行评估。所有受试者将遵循12个月。正如A.6中的试验数据所支持的那样，假设1的是，LRS较低的LRS饮酒的个体将表明大量饮酒和随后的问题的减少最大，而在参与LRB组的重点是他们的特定脆弱性。假设2是，LR BRB组高的LR（同时也减少了大量饮酒）将表明SOTA组的减少最大，该组解决了与LR无关的脆弱性，但与冲动性，情绪失调和其他风险因素有关。11假设3是在LRB和SOTA协议中纳入的干预措施与未来的饮酒相关，而与未来相关的饮酒量则与之相关。如果假设被证明是正确的，则结果可能是大学如何通过根据预防措施来改善饮酒结果的一个例子，从而为其他特定的先前存在的风险因素定制工作。