LEVEL OF RESPONSE TO ALCOHOL AND BRAIN FUNCTIONING

对酒精的反应水平和大脑功能

• 批准号: 7276740
• 负责人: Marc A Schuckit
• 金额: $ 30.28万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7276740
• 关键词: Acclimatization; Accounting; Acute; Affect; Age; Alcohol consumption; Alcohol dependence; Alcoholic Intoxication; Alcoholism; Alcohols; Analysis of Variance; Attenuated; Behavioral; Beverages; Biochemical Genetics; Blood; Blood Volume; Blood flow; Brain; Brain imaging; Cerebrum; Characteristics; Claustrophobias; Cognitive; Consumption; Core-Binding Factor; Coupling; Data; Development; Diagnostic; Dose; Ethanol; Exclusion; Family history of; Feeling; Follow-Up Studies; Functional Magnetic Resonance Imaging; Future; Gender; Genes; Genetic; Hand; Height; Hormones; Hour; Image; Individual; Individual Differences; Interview; Intoxication; Left; Link; Magnetic Resonance Imaging; Mails; Measures; Medical; Mental disorders; Metabolism; Metals; Methods; Motor; Nicotine; Oral; Oxygen; Participant; Patient Self-Report; Pattern; Performance; Pharmaceutical Preparations; Phenotype; Placebos; Prefrontal Cortex; Pregnancy; Process; Race; Randomized; Rate; Reaction; Recording of previous events; Relative (related person); Research; Research Personnel; Rest; Risk; Risk Factors; Sampling; Scanning; Short-Term Memory; Spin Labels; Standards of Weights and Measures; Substance Addiction; System; Testing; Time; Visual; Week; Weight; Woman; Work; alcohol related problem; alcohol response; alcohol use disorder; base; blood oxygen level dependent; drinking; eligible participant; endophenotype; executive function; experience; falls; instrument; men; neuroimaging; programs; relating to nervous system; response; university student; young adult

DESCRIPTION (provided by applicant): The primary aim of the revised application is to understand cognitive features and brain systems that differentiate low- and high-level responders to alcohol, while under the influence of alcohol and without alcohol intoxication. Participants will be young adults ages 18-25 with the following exclusions: history of substance dependence or major psychiatric disorder, medical illness or use of medications that might interfere with alcohol challenge or affect brain imaging results, pregnancy, have had unpleasant reactions to moderate alcohol doses, left handed, or magnetic resonance imaging contraindications (e.g., metal, claustrophobia). Participants will be selected from annual mailings to college students, and classified as low or high level responders to alcohol, initially based on a standardized self-report instrument. Potential participants will receive a detailed diagnostic interview, and a traditional alcohol challenge to confirm level of response to alcohol and comfort in consuming moderate doses. Low (n=50) and high (n=50) level responders will be matched on: height, weight, race, gender, and recent use of alcohol, nicotine, and other drugs. Eligible participants will receive functional magnetic resonance imaging (fMRI) two times: after drinking moderate doses of alcohol (up to 0.68 ml/kg alcohol for women and up to 0.75 ml/kg alcohol for men) and after drinking placebo. Order of beverage administration will be randomized. Each fMRI assessment will administer Visual Working Memory and Sensorimotor tasks during blood oxygen level dependent scan acquisition, structural MRI (for spatial localization), and arterial spin labeling (to control blood flow differences). The imaging session will start 30 minutes after beverage administration and last one hour, recording results at rising and falling BACs. The two imaging sessions will occur within the same week. Data will be compared in 2x2 analyses of variance to compare brain activation between low and high level responders with and without alcohol intoxication. These results will potentially develop a method for identifying low responders (a group at high risk for alcoholism) even before their first drink. The project will also expand our understanding of the neural substrates of the level of response to alcohol, a key risk factor for the development of alcohol dependence.

描述（由申请人提供）：修订后的应用的主要目的是了解在酒精的影响下，而没有酒精中毒的情况下，可以理解低水平和高级响应者的认知特征和大脑系统。参与者将是18-25岁的年轻人，具有以下排他性：物质依赖的史或主要的精神疾病，医学疾病或使用可能干扰酒精挑战或影响脑成像结果的药物的使用，怀孕，对中度酒精剂量，左手治疗或磁性共振成像成像的反应不愉快（例如参与者将从年度邮寄给大学生的邮件中，并根据标准化的自我报告工具归类为对酒精的低水平或高水平响应者。潜在的参与者将获得详细的诊断面试，以及传统的酒精挑战，以确认对酒精的反应水平和中等剂量的舒适性。低（n = 50）和高（n = 50）水平响应者将与：身高，体重，种族，性别以及最近使用酒精，尼古丁和其他药物的使用。合格的参与者将两次获得功能性磁共振成像（fMRI）：在饮用中等剂量的酒精（女性最高0.68 ml/kg酒精，男性酒精含量高达0.75 ml/kg）和饮用安慰剂后。饮料管理顺序将被随机分组​​。每个功能磁共振成像评估都将在血氧水平依赖扫描，结构MRI（用于空间定位）和动脉自旋标记（控制血流差异）期间执行视觉工作记忆和感觉运动任务。成像会议将在饮料给药后30分钟开始，最后一个小时开始，记录结果的升高和下降BAC。这两个成像会议将在同一周内举行。将在2x2方差分析中比较数据，以比较有或没有酒精中毒的低水平和高水平反应者之间的大脑激活。这些结果可能会开发一种方法，即使在第一次饮料之前，也可以识别低响应者（一个有酗酒风险的群体）。该项目还将扩展我们对酒精反应水平的神经基质的理解，这是酒精依赖性发展的关键风险因素。