Speech Perception Impairments in Healthy Normal-Hearing Adults: Neural Mechanisms

健康正常听力成年人的言语感知障碍：神经机制

• 批准号: 8637221
• 负责人: EDWARD T AUER
• 金额: $ 30.5万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8637221
• 关键词: Accounting; Adopted; Adult; Age-Years; Agreement; Area; Attention; Audiology; Auditory; Auditory Brainstem Responses; Auditory Perceptual Disorders; Auditory system; Awareness; Behavior; Behavioral; Central Auditory Processing Disorder; Child; Clinic; Clinical; Conscious; Data; Databases; Detection; Development; Developmental Disabilities; Diagnosis; Electroencephalography; Environment; Event; Goals; Hearing; Impairment; Individual; Individual Differences; Intelligence; Intervention; Measures; Memory; Methodology; Methods; Neurologic; Noise; Participant; Patient Self-Report; Patients; Peripheral; Process; Qualifying; Reaction Time; Recording of previous events; Recruitment Activity; Reporting; Resources; Rest; Sampling; Short-Term Memory; Sorting - Cell Movement; Speech; Speech Audiometry; Speech Perception; Speed; Stimulus; Symptoms; Syndrome; Testing; Tympanometry; attentional modulation; base; clinical Diagnosis; clinically relevant; cognitive neuroscience; design; developmental disease; experience; hearing impairment; memory recognition; mental state; neuroimaging; neuromechanism; normal aging; otoacoustic emission; phonology; physical conditioning; public health relevance; relating to nervous system; research clinical testing; response; screening; volunteer; young adult

DESCRIPTION (provided by applicant): The goals of this project are to develop measures for studying speech perception impairments in healthy younger adults with normal hearing and without developmental disorders and to obtain a database of individual differences measures to analyze in relationship to experimental measures. Healthy adults with speech perception impairments may present at an audiology clinic complaining of difficulty perceiving speech under degraded listening conditions, yet upon examination they are found to be audiologically normal. But speech-in- noise testing confirms their complaint. They may then be considered for a clinical diagnosis of central auditory processing disorder (CAPD), but there is not agreement as to how to diagnosis CAPD; there are no standard tests of CAPD; and unknown even is whether its cause is a disorder of auditory processing. No neural bases have been confirmed. Cognitive neuroscience offers a framework for investigating the neural bases for speech perception impairment (SPI) in otherwise healthy young adults. We hypothesize those individuals who complain of speech perception difficulties exist on a continuum of individual differences. We hypothesize that the neural mechanisms responsible for the SPI could arise singly or in interaction at the levels of stimulus representation, attention, and working memory. A delayed recognition memory paradigm will be developed to investigate these mechanisms. The paradigm is designed to obtain behavioral and electrophysiological (EEG) measures in response to speech. Healthy adults with normal hearing and with SPI will be recruited for study and compared to similar age normal adults without speech perception impairments. All participants will undergo a battery of audiological tests and other screening, including tests for verbal intelligence, mental status, and phonological working memory. Then they will be tested in the proposed delayed recognition memory paradigm to gain behavioral and EEG results related to working memory, attention, and speech stimulus encoding. Stimuli will be nonsense syllables or real words that are either natural recordings or vocoded. Extensive individual differences and group statistical analyses will be carried out using the EEG, behavioral, and clinical measures. Individual differences scores will be sought across normal and SPI groups and as reliable predictors of group membership. With better understanding of neural mechanisms responsible for differences in speech perception across groups and individuals, clinical evaluations can become more accurate and treatments can be developed. We envision carrying this project forward to develop clinical tests for adults and also children.

描述（由申请人提供）：该项目的目标是制定措施，以研究患有正常听力且没有发育障碍的健康年轻人的语音感知障碍，并获得了个体差异措施的数据库，以分析与实验措施的关系。健康的成年人患有言语感知障碍可能会出现在听力学诊所中，抱怨在听力条件下降解的言语难以感知言语，但在检查时，发现它们在听力学上是正常的。但是语音测试证实了他们的投诉。然后，可以考虑使用中央听觉加工障碍（CAPD）的临床诊断，但对于如何诊断CAPD毫无共识。没有CAPD的标准测试；甚至未知的是它的原因是否是听觉处理障碍。尚未确认神经碱。认知神经科学提供了一个框架，用于研究健康的年轻人中语音感知障碍（SPI）的神经基础。我们假设那些抱怨言语感知困难的人存在于个体差异的连续体中。我们假设负责SPI的神经机制可能会单独出现，也可以在刺激表示，注意力和工作记忆的水平下进行相互作用。一个 将开发延迟的识别记忆范式来研究这些机制。该范式旨在获得响应语音的行为和电生理（EEG）措施。具有正常听力和SPI的健康成年人将被招募进行研究，并将其与类似的正常成年人进行比较而没有言语感知障碍。所有参与者将经过一系列听力学测试和其他筛查，包括言语智能，心理状态和语音工作记忆的测试。然后，将在提出的延迟识别记忆范式中对其进行测试，以获得与工作记忆，注意力和语音刺激编码有关的行为和脑电图结果。刺激将是自然记录或录音的无意义音节或真实单词。将使用脑电图，行为和临床指标进行广泛的个体差异和群体统计分析。个体差异得分将在正常和SPI组之间寻求，并作为小组成员资格的可靠预测指标。通过更好地了解负责各组和个体语音感知差异的神经机制，临床评估可以变得更加准确，并且可以开发治疗。我们设想携带该项目前进，以开发成人和儿童的临床测试。