Acquisition of an X-Rad 320 Biological Irradiator

购买 X-Rad 320 生物辐照器

• 批准号: 8703903
• 负责人: David E Levy
• 金额: $ 16.47万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-17 至 2016-02-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8703903
• 关键词: Animal Housing; Animals; Area; Basic Science; Biological; Cancer Immunology Science; Cardiology; Cesium; Cobalt; Communicable Diseases; DNA Repair; Data; Faculty; Frequencies; Funding; Future; Housing; Hurricane; Inflammation; Isotopes; Laboratories; Minor; Procedures; Radiation; Radioactive; Radioisotopes; Recruitment Activity; Reliance; Research; Research Personnel; Research Project Grants; Resources; Rodent; Science; Security; Source; Translational Research; Tube; United States National Institutes of Health; base; instrument; irradiation

DESCRIPTION (provided by applicant): We are requesting funds for a Precision X-Rad 320 Biological Irradiator. This instrument will provide 450kB high stability, high frequency x-rays, providing a highly reproducible and coherent irradiation field. There are numerous research projects at NYULMC that rely on the ability to deliver controlled irradiation to experimental rodents housed within the barrier vivarium. Due to Hurricane Sandy, the irradiator in the Smilow Central Animal Vivarium was destroyed. The vivarium is being reconstructed in the West Tower of the Alexandria Center. Availability of an animal irradiator is vital for ongoing projects on animals to be housed in this vivarium. A major advantage of the requested instrument is its reliance on an x-ray tube as a radiation source, rather that the more traditional isotope irradiators that contain radioactive cesium or cobalt. Thus, the X-Rad 320 lacks the major Homeland Security concerns inherent in maintaining a radioisotope-based irradiator, greatly simplifying installation, use, and oversight. The Precision X-Rad 320 will be placed within a shared procedure space within the West Tower Vivarium, where is will be available for use by the laboratory staff of the major user group, as well as ancillary minor users. The unit will be under the oversight of the Division of Laboratory Resources of the Office of Science and Research. It will be directly administered by the PI of this application, Assoc. Dean David Levy and his administrative staff in the Office of Collaborative Science. The major and minor user group comes from numerous academic departments and represents both basic and translational research areas, such as, cancer, immunology, infectious diseases, cardiology, inflammation, and DNA repair. The NIH funded users combined will use 75% of the instrument capacity. Remaining instrument capacity will be made available to any researcher with animals housed in the vivarium through an on-line scheduler. These investigators will be largely newly-recruited junior faculty who are gathering data in support of their first submissions to NIH. The availability of this instrument in a Core setting will make it fully available to all users, includng future users as they acquire NIH funding and research needs of animal irradiation. Although there are other animal irradiators on campus, the special needs of research on animals housed under barrier conditions require that each barrier vivarium have its own irradiator. Therefore, there is no substitute for a dedicated irradiator such as this within the West Tower Vivarium.

描述（由申请人提供）：我们正在请求资金购买 Precision X-Rad 320 生物辐照器。该仪器将提供450kB高稳定性、高频X射线，提供高度可重复性和相干的照射场。纽约大学医学中心有许多研究项目依赖于向屏障动物园内的实验啮齿动物提供受控辐射的能力。由于桑迪飓风，斯米洛中央动物动物园的辐射器被毁。亚历山大中心西塔正在重建动物园。动物辐照器的可用性对于该动物园中正在进行的动物项目至关重要。所需仪器的一个主要优点是它依赖 X 射线管作为辐射源，而不是包含放射性铯或钴的更传统的同位素辐照器。因此，X-Rad 320 消除了维护基于放射性同位素的辐照器所固有的主要国土安全问题，从而大大简化了安装、使用和监督。 Precision X-Rad 320 将放置在西塔动物园内的共享程序空间内，可供主要用户组的实验室工作人员以及辅助次要用户使用。该单位将接受科学研究办公室实验室资源司的监督。它将由该应用程序的 PI Assoc 直接管理。大卫·利维院长和他在合作科学办公室的行政人员。主要和次要用户群体来自多个学术部门，代表基础和转化研究领域，例如癌症、免疫学、传染病、心脏病学、炎症和 DNA 修复。 NIH 资助的用户合计将使用 75% 的仪器容量。剩余的仪器容量将通过在线调度程序提供给饲养在动物园中的动物的任何研究人员。这些研究人员主要是新招募的初级教员，他们正在收集数据以支持他们向 NIH 的首次提交。该仪器在核心环境中的可用性将使其完全可供所有用户使用，包括未来的用户，因为他们获得了 NIH 的资金和动物辐照的研究需求。尽管校园内还有其他动物辐照器，但对屏障条件下饲养的动物进行研究的特殊需要要求每个屏障动物园都有自己的辐照器。因此，西塔动物园内的专用辐照器是无可替代的。