Reproductive Biology and Genomics Training Program

生殖生物学和基因组学培训计划

• 批准号: 8681485
• 负责人: MARK S ROBERSON
• 金额: $ 17.02万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8681485
• 关键词: Genomics; Reproductive Biology; Training Programs

DESCRIPTION (provided by applicant): The overall goal of the renewal of this Program is to continue to provide comprehensive and in-depth research training in the reproductive sciences, centrally integrating training in the tools of functional mammalian genomics/genetics and computational biology. To accomplish this goal, a select group of graduate and postdoctoral trainees will have the opportunity to choose and be trained by dual mentors; the primary Trainer having expertise in the reproductive sciences and the Co-Trainer with expertise in genomics and/or computational biology. Eighteen (18) faculty trainers are represented in this application. We are requesting support for two (2) baccalaureate PhD slots and three (3) postdoctoral slots (one of which is reserved for a MD/DVM-Seeking-PhD trainee), each for a two-year training interval. Support is requested for a total of five (5) years for this training program. The philosophy behind this proposed training plan is based upon the appreciation that biomedical researchers in the reproductive sciences would benefit greatly from parallel training in practical and applied use of genome-wide investigative techniques. Cornell University is uniquely poised for a training program in reproductive sciences that spans male and female physiology, the genetic bases of fertility, physiology of the maternal-fetal interface, cell signaling and molecula endocrinology and the molecular and genetic basis for reproductive cancers. In addition, the proposed program will benefit greatly by inclusion of faculty members with interests in non-mammalian models of reproduction in Drosophila and C. elegans to facilitate comparative evolutionary studies. Training in the genomics and computational areas will emphasize the following (some examples): creation and use of transgenic and knockout models (animal models for the study of fertility as well as models of disease pathophysiology emphasizing reproductive neoplasia); use of micro arrays and bioinformatics analyses including comprehensive training in manipulation of databases for model organisms and genomic browsers/portals that serve to aid in determination of genotype/phenotype relationships; creation of computer-based modeling to facilitate informed decisions on structure/function relationships; analysis of gene transcription networks based upon application of principles of comparative genomics. The faculty involved in this proposed Program is committed to facilitating a training environment in the reproductive sciences and its interface with genome structure and activity. The collaborative effort(s) between Trainers and coTrainers is the cornerstone of this program. This unique scientific and technical interface will enhance the opportunity for pre- and postdoctoral trainees to leave this environment well-trained in the reproductive sciences and in multiple state-of-the-art techniques and applications in genomics that will optimize their continued success in continued training (transitioning to postdoctoral) or the acquisition of scientific positions in academia, government or industry.

描述（由申请人提供）：本计划更新的总体目标是继续提供生殖科学领域全面、深入的研究培训，集中整合功能哺乳动物基因组学/遗传学和计算生物学工具的培训。为了实现这一目标，一批精选的研究生和博士后学员将有机会选择双导师并接受双导师的培训；主培训师具有生殖科学方面的专业知识，辅助培训师具有基因组学和/或计算生物学方面的专业知识。本申请中有十八 (18) 名教员培训师。我们请求支持两 (2) 个学士学位博士名额和三 (3) 个博士后名额（其中一个预留给 MD/DVM 寻求博士生），每个名额的培训间隔为两年。该培训计划请求总共五 (5) 年的支持。该拟议培训计划背后的理念是基于这样的认识：生殖科学领域的生物医学研究人员将从全基因组研究技术的实际和应用使用的并行培训中受益匪浅。康奈尔大学为生殖科学培训项目做好了独特的准备，该项目涵盖男性和女性生理学、生育力的遗传基础、母胎界面的生理学、细胞信号传导和分子内分泌学以及生殖癌症的分子和遗传基础。此外，拟议的计划将因纳入对果蝇和线虫非哺乳动物繁殖模型感兴趣的教员而受益匪浅，以促进比较进化研究。基因组学和计算领域的培训将强调以下内容（一些例子）：转基因和基因敲除模型的创建和使用（用于研究生育力的动物模型以及强调生殖肿瘤的疾病病理生理学模型）；使用微阵列和生物信息学分析，包括对模型生物和基因组浏览器/门户数据库操作的综合培训，以帮助确定基因型/表型关系；创建基于计算机的建模，以促进对结构/功能关系的明智决策；基于比较基因组学原理的应用分析基因转录网络。参与该拟议计划的教师致力于促进生殖科学及其与基因组结构和活动的相互作用的培训环境。培训师和协同培训师之间的协作努力是该计划的基石。这种独特的科学和技术界面将增加博士前和博士后学员在这个环境中接受生殖科学和基因组学多种最先进技术和应用方面良好培训的机会，这将优化他们在持续发展中的持续成功。培训（过渡到博士后）或 在学术界、政府或工业界获得科学职位。