WHITE MATTER DAMAGE IN AGE-RELATED COGNITIVE DECLINE

与年龄相关的认知衰退中的白质损伤

• 批准号: 8357822
• 负责人: Larry S. Sherman
• 金额: $ 5.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357822
• 关键词: Age-associated memory impairment; Alzheimer' s Disease; Blood Vessels; Cognition Disorders; Funding; Goals; Grant; Hyaluronan; Impaired cognition; Metabolism; National Center for Research Resources; Oxidative Stress; Patients; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Testing; United States National Institutes of Health; brain tissue; cognitive change; cost; white matter damage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this project is to test how oxidative stress, vascular changes, cognitive changes and alterations in hyaluronan metabolism correlate in patients with vascular cognitive impairment, Alzheimer's disease, and other cognitive disorders compared to unaffected patients. This project focuses on characterizing changes in hyaluronan metabolism in brain tissues from these patients.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目的目标是测试与未受影响的患者相比，血管性认知障碍、阿尔茨海默病和其他认知障碍患者的氧化应激、血管变化、认知变化和透明质酸代谢改变之间的关系。 该项目的重点是表征这些患者脑组织中透明质酸代谢的变化。