MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE

非人灵长类动物胎儿肝脏编程机制

• 批准号: 8357764
• 负责人: KEVIN L GROVE
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357764
• 关键词: Animals; Development; Diet; Fatty acid glycerol esters; Funding; Gluconeogenesis; Grant; Health; Hepatic; Lipolysis; Liver; Metabolic; Muscle; National Center for Research Resources; Pathway interactions; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; Sampling; Source; System; United States National Institutes of Health; cost; fetal; insulin signaling; lipid biosynthesis; nonhuman primate; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall purpose of this project is to determine the effect of maternal high fat/calorie diet and metabolic health on the developmental programming of metabolic systems in the liver and muscle. These studies are focusing on the reprogramming of the insulin signaling, lipogenesis/lipolysis, and gluconeogenesis pathways. Our role in these studies is primarily supportive through assistance with the animal management and obtaining samples.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目的总体目的是确定母亲高脂肪/热量饮食和代谢健康对肝脏和肌肉代谢系统发育规划的影响。这些研究的重点是胰岛素信号传导、脂肪生成/脂肪分解和糖异生途径的重编程。我们在这些研究中的作用主要是通过协助动物管理和获取样本来提供支持。