Temporal Trends in Food Sensitization in U.S. Children

美国儿童食物过敏的时间趋势

• 批准号: 8564924
• 负责人: Corinne Keet
• 金额: $ 30.46万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-05 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8564924
• 关键词: 20 year old; Allergens; Biological Markers; Centers for Disease Control and Prevention (U.S.); Child; Clinical; Data; Diagnosis; Disease; Epidemic; Epidemiology; Ethnic Origin; Ethnic group; Food; Food Hypersensitivity; Hispanics; Hypersensitivity; IgE; Investments; Laboratories; Manuscripts; Measures; Milk; National Health and Nutrition Examination Survey; Not Hispanic or Latino; Outcome Measure; Patient Self-Report; Peanuts - dietary; Population; Prevalence; Questionnaires; Reporting; Research; Sampling; Serum; Shrimp; Surveys; Testing; Time; United States National Institutes of Health; aged; base; caucasian American; egg; environmental change; experience; food allergen; high risk; primary outcome; public health relevance; racial and ethnic disparities; systematic review; trend

DESCRIPTION (provided by applicant): Food allergy appears to have risen rapidly in prevalence over the past few decades, leading to much research into the causes of this apparent 'epidemic'. Yet, because the data showing increased prevalence are largely based on questionnaires, and we know that questionnaires overestimate clinically confirmed food allergy, we truly do not know how real the apparent epidemic is. It is possible that the increased prevalence seen in the questionnaires represents changes in the diagnosis of food allergy, and that biologic markers of this disease remain unchanged. An additional unknown is whether the growing ethnic/racial disparities in food allergy prevalence seen in the self-reported data relate to true biologic differences. In order to determine whether the trends that are found in self reported food allergy correlate with changes in biologic measures of food allergy, we propose to measure food specific IgE in stored samples from the National Health and Nutrition Examination Survey (NHANES) III, collected from 1988-1994, in order to compare it to that already measured in NHANES 2005-6. Aim 1 is to compare the prevalence of sensitization and higher likelihood of clinical food allergy, both as measured by specific IgE to milk, egg, peanut or shrimp, in U.S. children over this approximately 15 year period. Aim 2 is to test the hypothesis that Non-Hispanic Blacks have experienced greater increases in prevalence of sensitization and higher specific IgE over this period. Combined, these aims will answer fundamental questions in the field of food allergy epidemiology.

描述（由申请人提供）：过去几十年来，食物过敏的患病率似乎迅速上升，导致人们对这种明显“流行病”的原因进行了大量研究。然而，由于显示患病率增加的数据主要基于调查问卷，而且我们知道调查问卷高估了临床证实的食物过敏，因此我们确实不知道这种明显的流行病有多真实。调查问卷中患病率的增加可能代表食物过敏诊断的变化，而这种疾病的生物标志物保持不变。另一个未知数是，自我报告数据中食物过敏患病率日益增长的民族/种族差异是否与真正的生物学差异有关。为了确定自我报告的食物过敏趋势是否与食物过敏生物学指标的变化相关，我们建议测量来自国家健康和营养检查调查 (NHANES) III 的储存样本中的食物特异性 IgE，这些样本收集自1988-1994 年，以便将其与 NHANES 2005-6 中已测量的值进行比较。目标 1 是比较这大约 15 年期间美国儿童的致敏发生率和临床食物过敏的较高可能性（均通过对牛奶、鸡蛋、花生或虾的特异性 IgE 进行测量）。目标 2 是检验以下假设：在此期间，非西班牙裔黑人的致敏率和特异性 IgE 的发生率均出现较大增加。这些目标结合起来将回答食物过敏流行病学领域的基本问题。