Early Peanut Introduction: Translation to Clinical Practice

早期花生介绍：转化为临床实践

基本信息

批准号：
9491694
负责人：
Corinne Keet
金额：
$ 98.3万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-27 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9491694
关键词：
African American Allergens Allergic Allergy to eggs Allergy to peanuts Blood Categories Characteristics Child Clinical Clinical Trials Consensus Consumption Data Development Diagnosis Diagnostic Diet Dose Eczema Enrollment Ensure Ethnic Origin Family history of Food Hypersensitivity Frequencies Goals Gold Guidelines Hypersensitivity IgE Individual Infant Ingestion Investigation Life Measurement Measures Modality Observational Study Office Visits Oral Pattern Performance Population Prevention Primary Health Care Race Randomized Reaction Resources Risk Sensitivity and Specificity Siblings Telephone Testing Translations Underrepresented Groups Visit Work base clinical practice cohort ethnic difference ethnic minority population food challenge high risk high risk infant high risk population infancy meetings prevent prospective racial and ethnic racial and ethnic disparities randomized trial screening skin prick test

项目摘要

Project Summary: The recent finding that early introduction of peanut can prevent ~70-90% of peanut allergy is a major step towards prevention of food allergy. However, because that finding was from a clinical trial in a very select population, there are several major questions that must be answered in order to implement these findings into clinical practice without causing more harm than good. These questions include who, if anyone, should be screened prior to early introduction for peanut allergy, how this screening should be done, and what quantity of peanut ingestion is needed to prevent peanut allergy. Our goal is to answer these critical questions so that the potential of these recent findings can be realized. To that end, we will enroll 400 infants at high- risk of peanut allergy. These infants will be given a peanut skin prick test, peanut food challenge and have blood drawn for measurement of peanut IgE, and then will be followed for assessment of peanut consumption and development of peanut allergy. Aim 1 is to determine the rate of peanut reactivity in infancy among these high risk groups, Aim 2 is to characterize the performance of possible screening tests for peanut allergy in infancy, and Aim 3 is to characterize the peanut consumption patterns of these infants after screening and to determine the association with development of peanut allergy. Exploratory Aim 4 is to understand racial/ethnic disparities in risk of reactivity and diagnostic parameters of screening tests.

项目概要：最近发现早期引入花生可以预防约 70-90% 的花生过敏，这是一项然而，这是预防食物过敏的重要一步，因为该发现来自临床。在特定人群中进行的试验中，有几个必须回答的主要问题以便将这些发现应用到临床实践中，而不造成弊大于利的情况。这些问题包括在早期引入之前应该对谁（如果有人）进行筛查花生过敏，应该如何进行筛查以及花生的摄入量是多少我们的目标是回答这些关键问题，以便预防花生过敏。为了实现这些最新发现的潜力，我们将招募 400 名婴儿参加高中课程。这些婴儿将接受花生皮点刺试验、花生食品挑战。抽血检测花生IgE，然后进行跟踪评估目的 1 是确定花生过敏的发生率。这些高风险人群在婴儿期的花生反应性，目标 2 是表征婴儿期花生过敏可能筛查测试的表现，目标 3 是筛选后描述这些婴儿的花生消费模式并确定探索性目标 4 是了解与花生过敏的关系。筛查测试反应风险和诊断参数的种族/民族差异。