DCTD Animal Support

DCTD 动物支持

• 批准号: 8844929
• 负责人: DAVID HEIMBROOK
• 金额: $ 30.16万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8844929
• 关键词: Accreditation; Animal Experimentation; Animal Husbandry; Animal Model; Animals; Antibody Formation; Antineoplastic Agents; Area; Autoimmune Process; Autopsy; Bacterial Toxins; Biological; Biological Assay; Biological Testing; Caring; Charge; Chemistry; Clinical Trials; Communities; Consultations; Contracts; Development; Developmental Therapeutics Program; Diabetes Mellitus; Diagnostic; Diagnostic Services; Dichloroacetate; Disease; Disease Progression; Dose; Drug Kinetics; Early Diagnosis; Fluorescence; Funding; Gas Chromatography; Government Agencies; HIV; Health; Health Status; Helicobacter; High Pressure Liquid Chromatography; IACUC; Individual; Infection; Institution; International; Investigation; Knowledge; Laboratories; Laboratory Animal Medicine; Laboratory Animal Science; Laboratory Animals; Lead; Liquid substance; Malignant Neoplasms; Mass Spectrum Analysis; Metabolic; Metabolic Diseases; Methodology; Microbiology; Molecular; Monitor; Mus; Needs Assessment; Parasitology; Pharmaceutical Preparations; Pharmacology; Phase; Plasma; Play; Preclinical Testing; Production; Proteomics; Quarantine; Research; Resources; Rodent; Role; Route; Sampling; Schedule; Sentinel; Serologic tests; Services; Source; Spectrum Analysis; Support Groups; Testing; Time; United States; United States National Institutes of Health; Urine; Viral; Virus Diseases; Weight; animal care; animal efficacy; animal facility; base; biosecurity; drug candidate; human disease; in vivo; interest; pathogen; pre-clinical; preclinical study; prevent; programs; response; small molecule; square foot; ultraviolet

BTB Support - The Biological Testing Branch Support Group is responsible for providing information relating to the preclinical chemistry and pharmacology of new anticancer agents identified by the Developmental Therapeutics Program. The analysis of drug candidates in biological fluids involves creating, applying, and validating methodology for each drug candidate. This analytical methodology then permits investigation into possible inter-relationships between dose, bio-fluid (such as plasma or urine) concentration, and bio-effect. The results of such studies may lead to a better understanding of drug activity as well as suggest the best route and dose schedule for administration. Such efforts requires extensive knowledge of high performance liquid chromatography (HPLC), gas chromatography (GC), and molecular spectroscopy such as ultraviolet (UV), fluorescence, and all forms of mass spectrometry. Additionally, this group was charged with providing pharmacological support to the recently implemented NCI-sponsored Phase 0 clinical trials. In addition to the scientific studies supported by this effort, this group is also responsible for providing administrative support to the DCTD Animal Production Program. This program supplies rodents to the NCI, NIH, USAMRIID, FDA and other government agencies. In addition, surplus animals are provided to NIH grantees on an as-available basis. This effort supports many of the preclinical studies required to develop drugs to treat cancer, HIV and other viral diseases, bacterial and toxin-induced diseases, metabolic diseases including diabetes, immunologically induced conditions including autoimmune conditions, and other disease states supported by Federal research funds. DTP Animal QC - Animal models of human disease continue to play a pivotal role in our understanding of disease progression and treatment. As part of the support to the diverse array of animal model studies, DCTD has animal production contracts that provide rodents to the NCI, NIH, FDA, USAMRIID, other Federal agencies as well as NIH grantees on an as available basis. As part of this effort, DCTD routinely assesses the health status of the animals being distributed so as to assure the research community of the quality and biosecurity of the research animals they receive. To this end, the Laboratory Animal Sciences Program (LASP) provides diagnostic services for routine and special-need assessments of the health status of the animal production colonies. These assays include murine antibody production (MAP) tests which identify occult viral infections, PCR-based assays for Helicobacter and certain viral agents as well as bacteriological assessment of rodent and fomite-derived samples to assure the status of the production colonies. In addition, this laboratory monitors the health of all rodent colonies at NCI-Frederick which further protects the DCTD Animal Production Program by identifying and eliminating possible sources of infection within the Frederick campus. Animal Health Diagnostic Laboratory (AHDL) - The Animal Health Diagnostic Laboratory (AHDL) is responsible for monitoring the health of all rodents at NCI-Frederick, NCI-Bethesda, NCI-DTP Rodent Producers, and several NCI contract facilities. The AHDL also provides diagnostic resources to several other NIH facilities and USAMRIID. The major focus of the diagnostic services includes microbiology, parasitology, serology, and health-monitoring necropsies. The AHDL has been a consistent resource to the scientific community for more than 30 years. BTB Animal Care Support - SAIC-Frederick, Inc., and NCI Bethesda are among the 730 organizations, institutions, and companies worldwide that are accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). The animal support areas of LASP consist of the Animal Health Diagnostic Laboratory (AHDL), Animal Molecular Diagnostic Laboratory (AMDL), Receiving and Quarantine (R&Q), Laboratory Animal Medicine (LAM), and NCI animal facilities. The Laboratory Animal Sciences Program provides animal care support to the BTB in vivo preclinical testing effort as well as the PK studies group. This includes direct animal care at the individual cage level as well as support for cage washing and autoclaving as well as maintaining facility supplies of animal care related materials.

BTB 支持 - 生物测试部门支持小组负责提供与开发治疗计划确定的新型抗癌药物的临床前化学和药理学相关的信息。对生物体液中候选药物的分析涉及为每种候选药物创建、应用和验证方法。这种分析方法可以研究剂量、生物液体（例如血浆或尿液）浓度和生物效应之间可能的相互关系。此类研究的结果可能有助于更好地了解药物活性，并提出最佳的给药途径和剂量方案。这些工作需要高效液相色谱 (HPLC)、气相色谱 (GC) 和分子光谱（例如紫外 (UV)、荧光和所有形式的质谱）的广泛知识。此外，该小组还负责为最近实施的 NCI 赞助的 0 期临床试验提供药理学支持。除了这项工作支持的科学研究外，该小组还负责为 DCTD 动物生产计划提供行政支持。该计划向 NCI、NIH、USAMRIID、FDA 和其他政府机构提供啮齿动物。此外，剩余的动物将根据可用情况提供给 NIH 受资助者。这项工作支持许多临床前研究，以开发治疗癌症、艾滋病毒和其他病毒性疾病、细菌和毒素引起的疾病、包括糖尿病在内的代谢疾病、包括自身免疫性疾病在内的免疫引起的疾病以及联邦研究基金支持的其他疾病状态的药物。 。 DTP 动物 QC - 人类疾病的动物模型在我们了解疾病进展和治疗方面继续发挥着关键作用。作为对各种动物模型研究的支持的一部分，DCTD 签订了动物生产合同，在现有基础上向 NCI、NIH、FDA、USAMRIID、其他联邦机构以及 NIH 受资助者提供啮齿类动物。作为这项工作的一部分，DCTD 定期评估所分配动物的健康状况，以向研究界保证他们收到的研究动物的质量和生物安全性。为此，实验动物科学计划 (LASP) 为动物生产群体的健康状况的常规和特殊需要评估提供诊断服务。这些检测包括识别隐匿性病毒感染的鼠抗体产生 (MAP) 检测、基于 PCR 的螺杆菌和某些病毒制剂检测以及对啮齿动物和污染物样本进行细菌学评估，以确保生产菌落的状态。此外，该实验室还监测 NCI-弗雷德里克所有啮齿动物群落的健康状况，通过识别和消除弗雷德里克校区内可能的感染源，进一步保护 DCTD 动物生产计划。 动物健康诊断实验室 (AHDL) - 动物健康诊断实验室 (AHDL) 负责监测 NCI-Frederick、NCI-Bethesda、NCI-DTP Rodent Producers 和多个 NCI 合同设施的所有啮齿动物的健康状况。 AHDL 还为其他几个 NIH 机构和 USAMRIID 提供诊断资源。诊断服务的主要重点包括微生物学、寄生虫学、血清学和健康监测尸检。 30 多年来，AHDL 一直是科学界的重要资源。 BTB 动物护理支持 - SAIC-Frederick, Inc. 和 NCI Bethesda 是全球 730 个获得国际实验动物护理评估与认证协会 (AAALAC International) 认证的组织、机构和公司之一。 LASP 的动物支持领域包括动物健康诊断实验室 (AHDL)、动物分子诊断实验室 (AMDL)、接收和检疫 (R&Q)、实验动物医学 (LAM) 和 NCI 动物设施。实验动物科学计划为 BTB 体内临床前测试工作以及 PK 研究小组提供动物护理支持。这包括在单个笼子层面上的直接动物护理，以及对笼子清洗和高压灭菌的支持，以及维持动物护理相关材料的设施供应。