Genotyping for epidemiology studies

流行病学研究的基因分型

基本信息

批准号：
8654773
负责人：
DAVID HEIMBROOK
金额：
$ 526.19万
依托单位：
LEIDOS BIOMEDICAL RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-26 至 2018-09-25
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8654773
关键词：
Affect Area Basic Science Bioinformatics Cancer Burden Candidate Disease Gene Caring Cohort Studies Communities Custom DNA Data Data Analyses Data Set Data Storage and Retrieval Databases Disease Disease Outcome Division of Cancer Epidemiology and Genetics Electronics Employment Endometrial Carcinoma Environmental Risk Factor Epidemiologic Studies Epidemiologist Equipment and supply inventories Etiology European Family Generations Genes Genetic Genetic Markers Genetic Variation Genome Genomics Genotype Hodgkin Disease Housing Human Human Genetics Human Genome Individual Informatics Information Management Institution Intramural Research Program Investigation Kaposi Sarcoma Laboratories Laboratory Research Malignant Neoplasms Malignant neoplasm of brain Malignant neoplasm of cervix uteri Malignant neoplasm of esophagus Malignant neoplasm of larynx Malignant neoplasm of liver Malignant neoplasm of lung Malignant neoplasm of ovary Malignant neoplasm of pancreas Malignant neoplasm of prostate Malignant neoplasm of testis Malignant neoplasm of thyroid Malignant neoplasm of urinary bladder Management Information Systems Maps Meta-Analysis Metadata Metric Molecular Epidemiology Mosaicism Multiple Myeloma Mutation Non-Hodgkin&apos s Lymphoma Outcome Pathway interactions Pattern Phenotype Population Genetics Population Group Predisposition Preparation Production Proteomics Publications Quality Control Rectal Cancer Renal carcinoma Research Research Infrastructure Research Personnel Research Project Grants Resources Sampling Scientific Advances and Accomplishments Scientist Skin Cancer Solutions Staging Statistical Methods Surveys Techniques Technology Technology Transfer Therapeutic Intervention Uterine Cancer Work cancer genomics college cost cost effective database of Genotypes and Phenotypes design epidemiology study exome exome sequencing follow-up genetic analysis genetic epidemiology genetic variant genome wide association study improved leukemia malignant breast neoplasm malignant stomach neoplasm melanoma new product development next generation sequencing novel osteosarcoma quality assurance research and development secondary outcome tool

项目摘要

The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of germline genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians and basic research scientists in the intramural research program, the CGR developed the capacity to conduct genome-wide association studies (GWAS), candidate gene approaches, and next-generation sequencing applications to identify the heritable determinants of various forms of cancer. In addition to offering the latest in genomics technology, the CGR has a fully integrated laboratory supporting several functional areas: DNA Extraction and Staging Laboratory (DESL) for preparation of samples; Laboratory Information Management System (LIMS) for advanced sample, project, and inventory, tracking; comprehensive project management; production laboratory; quality assurance and control; research and development for focused research projects and new product development; and bioinformatics and scientific analysis capabilities, making it a unique collaborative center for NCI-driven scientific endeavors.

癌症基因组学研究 (CGR) 实验室的成立是为了研究种系遗传变异对癌症易感性和结果的影响。 CGR 与流行病学家、生物统计学家和基础研究科学家在校内研究项目中合作，开发了进行全基因组关联研究 (GWAS)、候选基因方法和下一代测序应用的能力，以识别各种疾病的遗传决定因素。癌症的形式。除了提供最新的基因组学技术外，CGR 还拥有一个完全集成的实验室，支持多个功能领域：DNA 提取和分期实验室 (DESL)，用于制备样品；实验室信息管理系统 (LIMS)，用于高级样品、项目和库存、跟踪；全面的项目管理；生产实验室；质量保证和控制；重点研究项目和新产品开发的研究与开发；生物信息学和科学分析能力，使其成为 NCI 驱动的科学事业的独特协作中心。