Diagnosis of Crystal-Based Arthropathies via Raman Spectroscopy

通过拉曼光谱诊断晶体关节病

基本信息

批准号：
8528336
负责人：
Ozan Akkus
金额：
$ 28.86万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8528336
关键词：
Adoption Affect Aliquot Arthritis Aspirate substance Biomedical Engineering Calcium Oxalate Calcium Pyrophosphate Calcium Pyrophosphate Dihydrate Chemicals Clinic Clinical Collaborations Collection Communities Complex Cost Savings Cystine Data Decision Making Deposition Deterioration Devices Diagnosis Diagnostic Procedure Disease Engineering Evaluation Facilities and Administrative Costs Fever Filtration Foundations Goals Gold Gout Head Health system Home environment Hospitals Image Impairment Inflammatory Investigation Joints Kidney Lasers Lead Letters Light Location Maps Medical Methods Microscope Microscopic Modality Morbidity - disease rate Pain Pathology Patients Perception Pharmaceutical Preparations Photons Physicians Preparation Prevalence Primary Health Care Process Pseudogout Quality Control Quality of life Raman Spectrum Analysis Reaction Research Resort Resources Rheumatology Roentgen Rays Sampling Sensitivity and Specificity Serum Signal Transduction Spottings Swelling Symptoms Syringes Techniques Technology Time Training Translating Urate Validation Work Xanthines arthropathies base calcium phosphate clinical Diagnosis clinical practice clinically relevant cost cost effective improved instrument medical specialties millimeter novel patient population point of care polarized light primary care setting programs prototype rheumatologist screening tool user-friendly

项目摘要

DESCRIPTION (provided by applicant): The overall goal of the proposed study is to assess the efficiency of diagnosing crystals leading to inflammation of joints using a cost-efficient device which uses laser light. The study will fabricate the device, collect samples from the clinic and determine the sensitivity of the method in comparison to existing clinical diagnostic methods.

描述（由申请人提供）：拟议研究的总体目标是评估使用具有成本效益的激光设备诊断导致关节炎症的晶体的效率。该研究将制造该设备，从诊所收集样本，并与现有的临床诊断方法相比确定该方法的灵敏度。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Wide-field Raman imaging of dental lesions.

牙齿病变的宽视场拉曼成像。

DOI：
10.1039/c4an00164h
发表时间：
2014
期刊：
The Analyst
影响因子：
0
作者：
Yang,Shan;Li,Bolan;Akkus,Anna;Akkus,Ozan;Lang,Lisa
通讯作者：
Lang,Lisa

Raman spectral classification of mineral- and collagen-bound water's associations to elastic and post-yield mechanical properties of cortical bone.

矿物质和胶原蛋白结合水与皮质骨弹性和屈服后机械性能关联的拉曼光谱分类。

DOI：
10.1016/j.bone.2015.07.024
发表时间：
2015
期刊：
Bone
影响因子：
4.1
作者：
Unal,Mustafa;Akkus,Ozan
通讯作者：
Akkus,Ozan

Laser Wavelength Dependence of Background Fluorescence in Raman Spectroscopic Analysis of Synovial Fluid from Symptomatic Joints.

有症状关节滑液拉曼光谱分析中背景荧光的激光波长依赖性。

DOI：
10.1002/jrs.4338
发表时间：
2013
期刊：
Journal of Raman spectroscopy : JRS
影响因子：
0
作者：
Yang,Shan;Li,Bolan;Slipchenko,MikhailN;Akkus,Anna;Singer,NoraG;Yeni,YenerN;Akkus,Ozan
通讯作者：
Akkus,Ozan

A customized Raman system for point-of-care detection of arthropathic crystals in the synovial fluid.

定制的拉曼系统，用于即时检测滑液中的关节病变晶体。