COBRE in Lipidomics and Pathobiology

COBRE 在脂质组学和病理生物学中的应用

基本信息

批准号：
8714006
负责人：
Besim Ogretmen
金额：
$ 109.48万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-19 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8714006
关键词：
Achievement Address Animal Disease Models Animal Model Animals Antifungal Agents Area Atherosclerosis Biological Biological Markers Biology Biology of Aging Cancer Biology Cancer Center Cardiovascular Diseases Centers of Research Excellence Ceramidase Ceramides Collaborations Colon Carcinoma Communicable Diseases Communities Complex Core Facility Core Protein Cryptococcus Data Development Diabetes Mellitus Diagnostic Diet Discipline Disease Disease Progression Educational workshop Ensure Environment Enzyme Inhibitor Drugs Enzyme Inhibitors Enzymes Evaluation Extramural Activities Faculty Fatty Acids Functional disorder Funding Future Genes Glucosylceramides Goals Grant Growth Growth and Development function Head and Neck Cancer High Density Lipoproteins Human Immune response Individual Industry Infection Inflammation Inflammatory Bowel Diseases Inflammatory Response Institution Insulin Resistance Interdisciplinary Study International Ischemia Journals Knock-out Laboratories Lead Leadership Lipids Malignant Neoplasms Medical Mentors Metabolic Diseases Metabolism Minority Mixed Function Oxygenases Muscle function Mutation Nerve Degeneration Neuronal Injury Pathogenesis Pathway interactions Peer Review Phase Physiological Physiology Pilot Projects Positioning Attribute Prostate Proteins Publications Recruitment Activity Regulation Relative (related person)Research Research Personnel Resources Rheumatoid Arthritis Role Rotation SKI gene Schedule Science Seeds Serum Services Smooth Muscle South Carolina Sphingolipids Strategic Planning Subgroup Targeted Research Testing Therapeutic Therapeutic Agents Translational Research Translations Universities Ursidae Family Woman Work angiogenesis assay development base cerebrovascular dihydroceramide desaturase drug development drug discovery enzyme pathway galactosylgalactosylglucosylceramidase high throughput screening inhibitor/antagonist innovation leukodystrophy macrophage meetings new therapeutic target novel preclinical study programs public health relevance ranpirnase research and development response success symposium therapeutic development vasculogenesis

项目摘要

DESCRIPTION (provided by applicant): The emerging Center in Lipidomics and Pathobiology at the Medical University of South Carolina (MUSC) builds on substantial accomplishments during the first two phases of the COBRE. These include mentoring of 19 targeted junior faculty investigators, 14 of whom have achieved independent extramural funding, 193 publications in peer-review journals by the target faculty, participation by more than 25 MUSC research faculty in COBRE activities, and development and enhancement of highly successful, innovative scientific core facilities, including a unique core in Lipidomics, and emerging focused cores in animal pathobiology (focused on lipid-based animal models) and a protein core focused on lipid enzymes and targets. The COBRE has also been very successful in recruiting minorities (2) and women (10) as target faculty. The organizing hypothesis states that the universe of bioactive lipids and related metabolites constitutes a complex network of diverse pathways regulating key physiologic functions. In turn, dysfunctions in these pathways contribute to the pathobiology of specific diseases. Counterbalancing the biological significance of lipids are unique considerations that arise from the relative difficulties of studying lipids and lipid-interacting proteins. These necessitate the development of competent shared facilities and collaborative efforts to bring various disciplines and expertise to bear on specific problems. Therefore, the strategic focus of the next phase is to achieve the development of a stand-alone Center of Lipidomics and Pathobiology at MUSC that will build on these remarkable scientific and institutional achievements and that will continue to catapult lipid research at MUSC. The overall objective is to capitalize on the exceptional strengths at MUSC in lipid biology with specific goal to: 1) define and develop specific thematic programmatic activities focusing on important pathobiology based on Center activities (e.g. cancer, neurodegeneration, metabolic disorders and infection/inflammation); 2) enhance translational research; 3) enhance mentoring to meet the increasing challenges of the current funding environment; 4) enhance the function of the cores and position them to better serve thematic and translational goals; 5) complete the development of the novel Lipidomics Portal; and 6) develop and achieve sustainability of the cores. We anticipate that these activities will result in a highly developed interdisciplinary research center with a critical mass of collaborative, independently and programmatically funded investigators in an evolving area of research of major significance to cancer biology, aging, inflammation, diabetes, neurodegeneration and infectious diseases.

描述（由申请人提供）：南卡罗来纳州医科大学（MUSC）的脂肪组学和病理学新兴中心（MUSC）建立在鞋底的前两个阶段的基础上。其中包括对19名有针对性的初级教师调查人员的指导，其中14名已经获得了独立的壁外资金，目标教师在同行评审期刊上进行了193个出版物，由25多名MUSC研究教师参与COBRE活动，以及非常成功的，创新的科学核心设施，包括唯一的核心核心，并在包括Lipidom和Emerigom inting Onding Onding Onding Onserob（包括核心核心）中，并增强了核心的核心，并增强了核心的核心。基于脂质的动物模型）和蛋白质核心的重点是脂质酶和靶标。该毛刺在招募少数族裔（2）和妇女（10）中也非常成功。组织假设指出，生物活性脂质和相关代谢产物的宇宙构成了调节关键生理功能的各种途径的复杂网络。反过来，这些途径中的功能障碍有助于特定疾病的病理生物学。平衡脂质的生物学意义是源于研究脂质和脂质相互作用蛋白的相对困难引起的独特考虑。这些需要开发有能力的共享设施和协作努力，以带来各种学科和专业知识，以解决特定问题。因此，下一阶段的战略重点是在MUSC建立一个独立的脂肪组学和病理学中心的发展，这将建立在这些非凡的科学和机构成就的基础上，并将继续在MUSC弹出脂质研究。总体目的是利用脂质生物学中MUSC的出色优势，其特定目标是：1）定义和开发基于中心活动（例如癌症，神经变性，代谢疾病和感染/炎症）的重要病理生物学的特定主题程序活动； 2）增强翻译研究； 3）加强指导，以应对当前资助环境的日益增长的挑战； 4）增强核心的功能并定位它们以更好地实现主题和翻译目标； 5）完成新型脂肪组学门户的发展； 6）发展和实现核心的可持续性。我们预计，这些活动将导致一个高度发展的跨学科研究中心，并在不断发展的研究领域，具有对癌症生物学，衰老，炎症，糖尿病，神经变性和感染性疾病的重要研究领域的重要合作，独立和程序化的研究人员。