La Jolla Interdisciplinary Neuroscience Center Cores

拉霍亚跨学科神经科学中心核心

• 批准号: 8666081
• 负责人: STUART A LIPTON
• 金额: $ 89.32万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8666081
• 关键词: Agreement; Alzheimer' s Disease; Award; Biological; Brain Diseases; Brain Neoplasms; California; Cancer Center Support Grant; Center Core Grants; Commit; Core Facility; Country; Development; Disease; Electrophysiology (science); Fostering; Funding; Glioblastoma; Goals; Grant; Huntington Disease; Institutes; Institution; Libraries; Medical Research; National Institute of Neurological Disorders and Stroke; Neurodegenerative Disorders; Neurodevelopmental Disorder; Neurons; Neurosciences; Neurosciences Research; Parkinson Disease; Qualifying; Rana; Recording of previous events; Research Institute; Research Personnel; Running; Scientist; Technology; United States National Institutes of Health; Universities; Work; Writing; developmental disease; innovation; interdisciplinary collaboration; medulloblastoma; migration; neoplastic; nervous system disorder; neuropathology; novel; optogenetics; programs; ranpirnase; screening; tumor

The overall goal of this interinstitutional NINDS P30 Core Grant is to foster new interdisciplinary collaborations among neuroscientists in La Jolla institutions by allowing access to scientific cores to which they were previously denied or had little access, and by promoting new cores to promote state-of-the-art technology; these cores were started under the prior auspices of the NIH Blueprint Core Grant (P30 NS057096) that was awarded to the PI, Dr. Lipton, for the past five years. Since the entire Blueprint Core Grant Program has been terminated by NIH, NINDS Program Officials asked us to submit this NINDS P30 Core Grant. To accomplish our goal, we have chosen among the very best core facilities on the Blueprint Core Grant, and have chosen top scientists to run these cores at the Sanford-Burnham Medical Research Institute (SBMIR) and the University of California San Diego (UCSD) in order to assist NINDS neuroscientists in La Jolla. The cores proposed here represent (i) High-Throughput (HS) Library Screening (at SBMRI), (ii) Neuropathology (at UCSD), and (iii) Electrophysiology (at SBMIR with Advisors at Salk), in addition to (iv) an Administrative Core (centered at SBMRI). These Core Facilities will be available to neuroscientists at all four institutions on the La Jolla Torrey Pines Mesa, composed of SBMRI, UCSD, Salk, and The Scripps Research Institute. These institutions share one of the top-rated neuroscience graduate programs in the country and have committed considerable institutional funds towards these cores. This work is aimed at developing new treatments for neurological disorders. The Specific Aims, which will be facilitated by all 3 Scientific Cores and the Administrative Core, are as follows: 1. To obtain Core support for Neuroscientists studying Neurodegenerative Disorders. The Cores will also help develop Neuroprotective Therapies. These disorders, represented in the Qualifying NINDS Projects of Major USERS, include Alzheimer's, Parkinson's, ALS, and Huntington's disease. 2. To obtain Core support for Neuroscientists studying Neoplastic Disorders of the brain. These disorders, represented in the Qualifying NINDS Projects of Major USERs, include glioblastoma multiforme and medulloblastoma tumors. 3. To obtain Core support for Neuroscientists studying Developmental Disorders. Disorders include abnormal neuronal migration, and are represented in NINDS Qualifying Projects of Major USERs.

这种机构间Ninds P30核心赠款的总体目标是通过允许访问以前被拒绝或几乎没有访问的科学核心来促进拉霍亚机构神经科学家之间的新跨学科合作，并促进新的核心来促进直接的先进技术；这些核心是在过去五年中授予PI授予PI的NIH蓝图核心拨款（P30 NS057096）的先前主持下的。由于NIH终止了整个蓝图核心赠款计划，因此NINDS计划官员要求我们提交此Ninds P30核心赠款。为了实现我们的目标，我们选择了Blueprint Core Grant上最好的核心设施之一，并选择了顶级科学家在Sanford-Burnham医学研究所（SBMIR）和加利福尼亚San Diego大学（UCSD）上运行这些核心，以帮助La Jolla的Ninds Neurscientists。此处提出的核心代表（i）高通量（HS）库筛选（在SBMRI），（ii）神经病理学（在UCSD上）和（iii）电生理学（在SBMIR在SBMIR，SALK顾问在SALK中），除了（IV）（IV）（IV）（iv）（iv）的行政核心（SBMRI中心）。这些核心设施将在由SBMRI，UCSD，Salk和Scripps Research Institute组成的La Jolla Torrey Pines Mesa上的所有四个机构的神经科学家使用。这些机构分享了该国最受欢迎的神经科学研究生计划之一，并向这些核心捐款了大量机构资金。这项工作旨在为神经系统疾病开发新的治疗方法。所有3个科学核心和行政核心将促进的具体目标如下： 1。为了获得研究神经退行性疾病的神经科学家的核心支持。核心还将有助于开发神经保护疗法。这些疾病在主要用户的合格NINDS项目中代表，包括阿尔茨海默氏症，帕金森氏症，ALS和亨廷顿氏病。 2。为了获得研究大脑肿瘤疾病的神经科学家的核心支持。这些疾病在主要用户的合格NINDS项目中代表，包括多形和髓母细胞瘤肿瘤的胶质母细胞瘤。 3。为了获得研究发育障碍的神经科学家的核心支持。疾病包括异常的神经元迁移，并在主要用户的Ninds合格项目中代表。