PHILA-NETT: Neurological Emergencies Treatment Trials (NETT) Network Clinical Hub

PHILA-NETT：神经急症治疗试验 (NETT) 网络临床中心

• 批准号: 8701419
• 负责人: NINA T GENTILE
• 金额: $ 26.91万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-03 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8701419
• 关键词: Academic Medical Centers; Accident and Emergency department; Acute; Address; Adherence; Adult; African American; Agreement; Ancillary Study; Anoxic Encephalopathy; Area; Blood Glucose; Brain Injuries; Caring; Childhood; Clinical; Clinical Research; Clinical Trials; Communication; Communities; Community Health Education; Community Hospitals; Controlled Study; Critical Care; Data; Development; Discipline; Drops; Emergency Medicine; Emergency treatment; Enrollment; Ensure; Feedback; Funding; Funding Opportunities; Grant; Health system; Hospitals; Human Resources; Incidence; Informatics; Injury; Insulin; Latino; Lead; Leadership; Low income; Mission; Monitor; Morbidity - disease rate; National Institute of Neurological Disorders and Stroke; Neurologic; Neurological emergencies; Neurology; Nurses; Online Systems; Outcome; Participant; Patient Care; Patient Recruitments; Patients; Pennsylvania; Philadelphia; Physicians; Process; Protocols documentation; Provider; Public Health; Radiology Specialty; Records; Rehabilitation therapy; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Rural Community; Scientist; Seizures; Services; Site; Stroke; Structure; Survivors; System; Testing; Therapeutic; Trauma; Traumatic Brain Injury; Treatment Effectiveness; United States National Institutes of Health; Universities; Work; acute stroke; base; blood glucose regulation; career; community setting; data management; disability; disorder prevention; flexibility; fundamental research; improved; insight; meetings; mortality; natural hypothermia; neurosurgery; research study; response; standard of care; statistical center; suburb; symposium; treatment trial; trend

DESCRIPTION (provided by applicant): Temple University (TU) serves as the Clinical Hub for the Philadelphia-area Neurological Emergency Treatment Trials (PHILA-NETT) network, a consortium of community and academic medical centers formed to effectively conduct clinical studies related to neurological emergencies. Over the past four years, the primary sites have included TU Health System hospitals and Hahnemann Hospital located in low- income areas of North Philadelphia with high proportions of African American and Latino patients. Temple Clinical Hub created a highly successful organization wherein staff works closely with site investigators and coordinators from multiple disciplines to efficiently execute NETT studies across all sites. Mechanisms that have enhanced the efficiency and quality of research across sites include, for example, the use of a common web-based informatics system developed to safely and quickly identify potential study patients; frequent and regular communication among investigators and coordinators; and diligent site management focused on good clinical research practices and compliance. Over the next five years, the consortium will expand within Philadelphia and across Pennsylvania to improve our reach and to meet the needs of the NETT as a whole. The PHILA-NETT structure is strong and sustainable and yet flexible enough to allow for expansion as needed to carry out the current and anticipated NETT studies. PHILA-NETT investigators have had career-long commitment to research in acute stroke, traumatic brain injury, therapeutic hypothermia and anoxic encephalopathy, all potential areas for NETT studies. These clinician-scientists in adult and pediatric Emergency Medicine, Neurology, Neurosurgery, Trauma, and Neuro-critical care are leaders in their communities and set the standards of care for patients with acute neurological illness and injury. Working with the NETT, the group will execute and design studies to address fundamental research questions. And most important to the mission of Temple University and to the communities in the Commonwealth, we will disseminate information and study results that will serve to guide and advance the treatment of patients with neurological emergencies.

描述（由申请人提供）：天普大学 (TU) 是费城地区神经紧急治疗试验 (PHILA-NETT) 网络的临床中心，该网络是一个由社区和学术医疗中心组成的联盟，旨在有效地开展与神经系统相关的临床研究紧急情况。在过去的四年里，主要地点包括位于费城北部低收入地区的 TU Health System 医院和 Hahnemann 医院，该地区非裔美国人和拉丁裔患者比例很高。 Temple Clinical Hub 创建了一个非常成功的组织，其中工作人员与来自多个学科的现场调查员和协调员密切合作，在所有现场高效执行 NETT 研究。提高跨站点研究效率和质量的机制包括，例如，使用基于网络的通用信息学系统，该系统旨在安全、快速地识别潜在的研究患者；调查员和协调员之间经常进行定期沟通；勤奋的现场管理注重良好的临床研究实践和合规性。在接下来的五年中，该联盟将在费城和整个宾夕法尼亚州扩展，以扩大我们的覆盖范围并满足整个 NTT 的需求。 PHILA-NETT 结构强大、可持续，而且足够灵活，可以根据需要进行扩展，以开展当前和预期的 NTT 研究。 PHILA-NETT 研究人员在整个职业生涯中致力于急性中风、创伤性脑损伤、治疗性低温和缺氧性脑病的研究，这些都是 NTT 研究的潜在领域。这些成人和儿科急诊医学、神经病学、神经外科、创伤和神经重症监护领域的临床科学家是其社区的领导者，为急性神经疾病和损伤患者制定了护理标准。该小组将与 NETT 合作执行和设计研究，以解决基础研究问题。对于天普大学和英联邦社区的使命来说，最重要的是，我们将传播信息和研究结果，以指导和推进神经急症患者的治疗。