Impact of host iron status on growth and viability of erythrocytic stages of Plas

宿主铁状态对 Plas 红细胞阶段生长和活力的影响

基本信息

批准号：
8326906
负责人：
Carla Cerami
金额：
$ 19.5万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-20 至 2013-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Iron deficiency is one of the most common micronutrient deficiencies in the world in pregnant women and children and it causes increased risk of perinatal mortality, morbidity and developmental delay. Recent evidence has suggested that iron deficiency may protect against malaria. Thus, the wisdom of universal supplementation in areas of the world where malaria is endemic has come under scrutiny. This application will attempt to identify the mechanism by which the human host's iron status affects the P. falciparum parasite in vitro. Specifically, we will determine if the growth, maturation and invasion rate of P. falciparum parasites is reduced in red blood cells and/or serum from severely iron deficient individuals before and after iron supplementation. The results will contribute to efforts to develop evidence-based iron supplementation policies in malaria-endemic areas. PUBLIC HEALTH RELEVANCE: Iron deficiency affects over 500 million people including many pregnant women and children from areas of the world that are plagued by malaria. It has been suggested that iron deficiency protects against malaria and questions have been raised about the risks associated with the universal iron supplementation programs in countries where malaria is endemic. In the proposed project, we will determine whether the growth and development of the malaria parasite is impacted by the host iron status in vitro. We will use RBC and sera from patients with severe iron deficiency anemia to look at this question in a very systematic way. This study will provide information for or against a possible mechanism by which iron deficiency may affect the malaria parasite. Ultimately, this information will provide additional evidence for the determination of policy on iron supplementation in malaria endemic regions.

描述（由申请人提供）：缺铁是世界上孕妇和儿童最常见的微量营养素缺乏症之一，它会导致围产期死亡、发病和发育迟缓的风险增加。最近的证据表明，缺铁可以预防疟疾。因此，在世界上疟疾流行地区普遍补充补充剂是否明智已受到密切关注。该应用将尝试确定人类宿主的铁状态在体外影响恶性疟原虫的机制。具体来说，我们将确定严重缺铁个体在补铁前后的红细胞和/或血清中恶性疟原虫的生长、成熟和侵袭率是否降低。研究结果将有助于在疟疾流行地区制定基于证据的铁补充剂政策。公共健康相关性：缺铁影响着超过 5 亿人，其中包括世界上疟疾肆虐地区的许多孕妇和儿童。有人认为，缺铁可以预防疟疾，并且有人对疟疾流行国家普遍补铁计划的相关风险提出了疑问。在拟议的项目中，我们将确定疟原虫的生长和发育是否受到体外宿主铁状态的影响。我们将使用严重缺铁性贫血患者的红细胞和血清来非常系统地研究这个问题。这项研究将为支持或反对缺铁可能影响疟疾寄生虫的可能机制提供信息。最终，这些信息将为疟疾流行地区铁补充剂政策的确定提供额外的证据。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis.

血红蛋白病：解决恶性疟原虫疟疾发病机制的棘手问题。

DOI：
发表时间：
2013
期刊：
影响因子：
6.7
作者：
Taylor, Steve M;Cerami, Carla;Fairhurst, Rick M
通讯作者：
Fairhurst, Rick M

Biopreservation of RBCs for in vitro Plasmodium falciparum culture.

用于体外恶性疟原虫培养的红细胞生物保存。

DOI：
发表时间：
2016
期刊：
影响因子：
6.5
作者：
Goheen, Morgan M;Clark, Martha A;Kasthuri, Raj S;Cerami, Carla
通讯作者：
Cerami, Carla

The role of the red blood cell in host defence against falciparum malaria: an expanding repertoire of evolutionary alterations.

红细胞在宿主防御恶性疟疾中的作用：不断扩大的进化改变。

DOI：
发表时间：
2017
期刊：
影响因子：
6.5
作者：
Goheen, Morgan M;Campino, Susana;Cerami, Carla
通讯作者：
Cerami, Carla

Influence of host iron status on Plasmodium falciparum infection.

宿主铁状态对恶性疟原虫感染的影响。

DOI：
发表时间：
2014
期刊：
影响因子：
0
作者：
Clark, Martha A;Goheen, Morgan M;Cerami, Carla
通讯作者：
Cerami, Carla

Anemia Offers Stronger Protection Than Sickle Cell Trait Against the Erythrocytic Stage of Falciparum Malaria and This Protection Is Reversed by Iron Supplementation.

贫血对恶性疟疾的红细胞期提供比镰状细胞性状更强的保护作用，而这种保护作用可以通过补充铁来逆转。

DOI：
发表时间：
2016-12
期刊：
影响因子：
11.1
作者：
Goheen, M M;Wegmüller, R;Bah, A;Darboe, B;Danso, E;Affara, M;Gardner, D;Patel, J C;Prentice, A M;Cerami, C
通讯作者：
Cerami, C