New England Regional Coordinating Center for the NINDS Stroke Trials Network

NINDS 卒中试验网络新英格兰地区协调中心

基本信息

批准号：
8662842
负责人：
Lee H Schwamm
金额：
$ 47.38万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8662842
关键词：
Academic Medical Centers Achievement Acute Address Adult Advocacy Agreement Ally American Heart Association Area Award Blood Vessels Boston Caring Child Clinical Clinical Investigator Clinical Research Clinical Sciences Clinical Trials Clinical Trials Network Collaborations Commit Community Hospitals Data Discipline Discipline of Nursing Educational Activities Emergency Medicine Emergency treatment Enrollment Environment Faculty Failure Funding Future General Hospitals Goals Health Hospitals Inpatients Institution Institutional Review Boards International Intervention Investigation Israel Lead Leadership Letters Massachusetts Medical Medical center Mission Modeling Multicenter Trials National Institute of Neurological Disorders and Stroke Neurologist Neurology Neurosciences Research New England Operative Surgical Procedures Outcome Patient Care Patients Pediatric Hospitals Performance Phase Phase III Clinical Trials Physicians Population Heterogeneity Populations at Risk Positioning Attribute Principal Investigator Protocols documentation Public Health Recording of previous events Records Recovery Recurrence Rehabilitation therapy Research Research Activity Research Infrastructure Research Institute Research Personnel Research Training Resources Risk Role Rural Hospitals Science Seasons Services Site Stroke Stroke prevention Therapeutic Training Training and Infrastructure Translating Translational Research United States National Institutes of Health Universities University Hospitals Vision Woman acute stroke base experience improved innovation member metropolitan multidisciplinary network models neuroimaging neurosurgery next generation novel operation patient population pre-clinical programs public health relevance research study skills stroke rehabilitation success treatment trial

项目摘要

DESCRIPTION (provided by applicant): We propose to create the New England Regional Coordinating Center (NERCC), an integrated team of hospitals and EMS agencies in Boston and Western Massachusetts that will serve as a top-enrolling site and vibrant contributor to the NINDS Stroke Trials Network. Our group includes many of the major adult academic stroke centers in the Greater Boston area, and our 30 hospital New England TeleStroke referral network will extend our potential recruitment even further. All core hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across disciplines. Principal investigator Lee H. Schwamm, MD, and Co-Investigators bring a complementary set of skills in managing successful translational clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation i both adults and children. Strengths of the NERCC team include 1) close personal and professional ties between multiple investigators; 2) large patient population from diverse hospital settings in a major metropolitan area; 3) talented teams of site investigators with track records o scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure; 5) existing clinical research programs, e.g., Neurology Clinical Research Institute, NIH Clinical and Translational Science Award programs at Boston University and across Harvard; Sites in the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) and Neurology Emergency Treatment Trials and NeuroNEXT Clinical Coordinating Center. In addition, integration with Boston and Worcester prehospital services will be leveraged to support the goals of the NERCC. Overall, the NERCC Team has the resources, vision, and enthusiasm to develop new translational science and successfully execute the NINDS Stroke Trials Network Phase 1, 2 and 3 studies.

描述（由申请人提供）：我们建议创建新英格兰地区协调中心 (NERCC)，这是一个由波士顿和马萨诸塞州西部的医院和 EMS 机构组成的综合团队，将作为 NINDS 中风的顶级招生网站和充满活力的贡献者试炼网．我们的团队包括大波士顿地区许多主要的成人学术卒中中心，我们的 30 家医院新英格兰 TeleStroke 转诊网络将进一步扩大我们的潜在招募范围。所有核心医院都拥有成功管理和临床试验绩效的良好记录。特别是，所有医院都拥有完善的研究基础设施，通过跨学科的强有力合作，开展中风神经病学的持续临床研究。首席研究员 Lee H. Schwamm 医学博士和联合研究员在管理成功的转化临床研究项目、指导委员会成员以及各自领域的国家领导职位方面带来了一套互补的技能。我们的团队包括血管神经病学、急诊医学、神经血管内、神经外科、神经重症监护、神经影像、中风康复以及成人和儿童临床前基础和转化中风研究方面经验丰富的临床研究人员。 NERCC 团队的优势包括 1) 多名研究者之间密切的个人和专业联系； 2）来自不同医院的大量患者位于主要大都市区的环境； 3) 才华横溢的现场调查人员团队，在多中心试验中拥有科学成就、创新和受试者招募记录； 4) 强大的现有 NINDS 资助的研究和临床试验管理基础设施； 5) 现有的临床研究项目，例如神经病学临床研究所、波士顿大学和哈佛大学的 NIH 临床和转化科学奖项目；急性中风转化研究 (SPOTRIAS) 和神经病学紧急治疗试验专门项目以及 NeuroNEXT 临床协调中心的站点。此外，将利用与波士顿和伍斯特院前服务的整合来支持 NERCC 的目标。总体而言，NERCC 团队拥有开发新的转化科学并成功执行 NINDS 中风试验网络第 1、2 和 3 期研究的资源、愿景和热情。