New England Regional Coordinating Center for the NINDS Stroke Trials Network

NINDS 卒中试验网络新英格兰地区协调中心

基本信息

批准号：
9753384
负责人：
Lee H Schwamm
金额：
$ 37.78万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9753384
关键词：
Achievement Acute Address Adult Advocacy American Heart Association Area Blood Vessels Boston Caring Child Childhood Clinical Clinical Investigator Clinical Research Clinical Trials Clinical Trials Network Clinical and Translational Science Awards Collaborations Community Hospitals Complement Discipline Discipline of Nursing Educational Activities Emergency Medicine Enrollment Environment Faculty Funding Future General Hospitals Goals Health Hospitals Infrastructure Inpatients Institution International Investigation Israel Lead Leadership Letters Maine Massachusetts Medical Medical center Mission Multicenter Trials National Institute of Neurological Disorders and Stroke Neurologist Neurology New England Operative Surgical Procedures Patient Care Patient-Focused Outcomes Patients Pediatric Hospitals Pediatrics Performance Phase Phase III Clinical Trials Physicians Population Heterogeneity Populations at Risk Positioning Attribute Principal Investigator Protocols documentation Public Health Recording of previous events Records Recovery Recurrence Rehabilitation therapy Research Research Activity Research Infrastructure Research Institute Research Personnel Research Training Resources Role Rural Hospitals Science Seasons Site Stroke Stroke prevention StrokeNet clinical trials Study Section Talents Testing Therapeutic Training Training and Infrastructure Translating Translational Research United States National Institutes of Health Universities Vision Woman base design early phase trial experience falls improved improved outcome innovation medical specialties member metropolitan multidisciplinary network models neuroimaging neurosurgery next generation novel novel therapeutics patient population pre-clinical programs recruit research study skills stroke clinical trials stroke neurology stroke rehabilitation stroke risk stroke trials success

项目摘要

We propose to continue the New England Regional Coordinating Center (NERCC), an integrated team of hospitals and EMS agencies in Boston and Western Massachusetts that will serve as a top-enrolling site and vibrant contributor to the NINDS Stroke Trials Network. Our group includes many of the major adult academic stroke centers in the Greater Boston area, and our 30+ hospital New England TeleStroke referral network will extend our potential recruitment even further. All core hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across disciplines. Principal investigator Lee H. Schwamm, MD, and Co-Investigators bring a complementary set of skills in managing successful translational clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation in both adults and children. Strengths of the NERCC team include 1) close personal and professional ties between multiple investigators; 2) large patient population from diverse hospital settings in a major metropolitan area; 3) talented teams of site investigators with track records of scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure; 5) existing clinical research programs, e.g., Neurology Clinical Research Institute, NIH Clinical and Translational Science Award programs at Boston University and across Harvard; Sites in the SIREN and NeuroNEXT Clinical Coordinating Center. Overall, the NERCC Team has demonstrated outstanding commitment and performance in the first StrokeNet cycle, and has the resources, vision, and enthusiasm to continue to develop new translational science and successfully execute the NINDS StrokeNet Phase 1,2 and 3 trials.

我们建议继续建立新英格兰地区协调中心（NERCC），这是一个由以下人员组成的综合团队：波士顿和马萨诸塞州西部的医院和 EMS 机构将作为主要招生地点， NINDS 中风试验网络的充满活力的贡献者。我们的团队包括许多主要的成人学者大波士顿地区的中风中心以及我们 30 多家新英格兰医院 TeleStroke 转诊网络将进一步扩大我们的潜在招聘范围。所有核心医院均拥有良好的成功记录临床试验的管理和执行。特别是，所有医院都有既定的研究正在进行中风神经病学临床研究的基础设施，并与各个领域进行强有力的合作学科。首席研究员 Lee H. Schwamm 医学博士和联合研究员带来了一套互补的管理成功的转化临床研究项目的技能、指导委员会的成员资格、以及在各自领域的国家领导地位。我们的团队包括经验丰富的血管临床研究人员神经内科、急诊医学、神经内血管、神经外科、神经重症监护、神经影像学、中风成人和儿童的康复、临床前基础和转化性中风研究。优势 NERCC 团队的成员包括 1) 多名研究者之间密切的个人和专业联系； 2）大来自主要大都市地区不同医院环境的患者群体； 3）现场优秀团队具有多中心科学成就、创新和受试者招募记录的研究人员试验； 4) 强大的现有 NINDS 资助的研究和临床试验管理基础设施； 5）现有临床研究项目，例如神经病学临床研究所、NIH 临床和转化科学奖波士顿大学和哈佛大学的项目； SIREN 和 NeuroNEXT 临床协调站点中心。总体而言，NERCC团队在第一届比赛中表现出了出色的承诺和表现 StrokeNet 周期，并拥有资源、愿景和热情来继续开发新的转化科学并成功执行了 NINDS StrokeNet 1、2 和 3 期试验。