Timing Effects of Heavy Alcohol Initiation on Adolescent Neurodevelopment

重度酒精开始对青少年神经发育的时间影响

基本信息

批准号：
8515884
负责人：
Bonnie J Nagel
金额：
$ 29.51万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-20 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8515884
关键词：
14 year old Addictive Behavior Address Adolescence Adolescent Affect Age Age of Onset Alcohol consumption Alcohol or Other Drugs use Alcoholism Alcohols Behavior Biological Assay Brain Brain region Characteristics Cognition Decision Making Development Dose Drug usage Family history of Functional Magnetic Resonance Imaging Functional disorder Heavy Drinking Hormonal Incidence Individual Intervention Interview Life Limbic System Link Longevity Measures Memory Monitor Moods National Institute on Alcohol Abuse and Alcoholism Neurocognition Neurocognitive Neuropsychological Tests Participant Pattern Performance Personality Predictive Value Prefrontal Cortex Prospective Studies Puberty Recording of previous events Recruitment Activity Relative (related person)Research Research Design Risk Risk Factors Risk-Taking Sampling Sex Characteristics Short-Term Memory Staging Strategic Planning Stress Structure System Techniques Teenagers Temperament Testing Time Youth abstracting addiction alcohol effect alcohol exposure alcohol use disorder alcohol use initiation base binge drinking brain volume critical period design discounting drinking drinking behavior early alcohol abuse early alcohol use executive function follow-up heavy drinking during adolescence high risk high risk behavior neurodevelopment neuroimaging neuropsychological neurotoxic response sex white matter

项目摘要

Abstract: Adolescence is a developmental period during which individuals engage in risk-taking behavior and are likely to initiate use of alcohol or other drugs. Past research suggests a strong correlation between early age of onset of alcohol use and a heightened vulnerability to addiction later in life. Adolescence is also a time of considerable neuromaturation, particularly in frontal brain regions thought to subserve higher level cognition, such as decision making and inhibition. Heavy alcohol use during these critical periods of brain development may permanently disrupt the course of maturation, resulting in long-term deficits in these functions and thereby increasing the risk of subsequent substance use behavior. The proposed R01 project is designed to prospectively and longitudinally examine the influence of developmental stage on the effects of alcohol on adolescent cognition, brain functioning, and brain structure, using neuroimaging and neuropsychological testing techniques. This project will examine neuropsychological performance during tests of executive functioning, brain functioning during executive and risk taking fMRI tasks, brain structure in prefrontal and limbic regions, and frontostriatal white matter integrity in 250 at-risk, non-using 12-14-year-old youth (based on family history of alcoholism). We hypothesize that youth who drink in adolescence will show abnormalities on these measures compared to developmentally-matched non-drinking youth, and that youth who initiate heavy drinking earlier in puberty will show greater abnormalities than teens that initiate heavy drinking later in development. This prospective study will answer critical questions about how developmental timing of adolescent heavy alcohol use initiation affects the developing brain.

抽象的：青春期是一个发展时期，在此期间，个人从事冒险行为，很可能是启动酒精或其他药物。过去的研究表明，发病年龄之间有很强的相关性以后生活中的饮酒和增加成瘾的脆弱性。青春期也是相当大的神经饱和，特别是在被认为可以得到更高水平认知的额脑区域例如决策和抑制。在这些关键时期大脑发育时期的大量饮酒可能会永久破坏成熟的过程，从而导致这些功能的长期缺陷，从而导致增加随后的物质使用行为的风险。拟议的R01项目旨在前瞻性和纵向研究发育阶段对酒精对影响的影响青少年认知，大脑功能和大脑结构，使用神经影像学和神经心理学测试技术。该项目将在执行测试期间检查神经心理学表现功能，执行期间的大脑功能以及承担fMRI任务，前额叶和大脑结构的风险和 250风险的边缘区域和额叶白质完整性，不使用12-14岁的青年（基于酒精中毒家族史）。我们假设青春期喝酒的年轻人会表现出异常这些措施与发育匹配的非饮食青年相比，以及那些开始沉重的年轻人在青春期早些时候饮酒会比以后发起大量饮酒的青少年显示出更大的异常发展。这项前瞻性研究将回答有关如何发展时机的关键问题青春期重饮酒的起始会影响发展中的大脑。