Timing Effects of Heavy Alcohol Initiation on Adolescent Neurodevelopment

重度酒精开始对青少年神经发育的时间影响

基本信息

批准号：
8515884
负责人：
Bonnie J Nagel
金额：
$ 29.51万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-20 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8515884
关键词：
14 year old Addictive Behavior Address Adolescence Adolescent Affect Age Age of Onset Alcohol consumption Alcohol or Other Drugs use Alcoholism Alcohols Behavior Biological Assay Brain Brain region Characteristics Cognition Decision Making Development Dose Drug usage Family history of Functional Magnetic Resonance Imaging Functional disorder Heavy Drinking Hormonal Incidence Individual Intervention Interview Life Limbic System Link Longevity Measures Memory Monitor Moods National Institute on Alcohol Abuse and Alcoholism Neurocognition Neurocognitive Neuropsychological Tests Participant Pattern Performance Personality Predictive Value Prefrontal Cortex Prospective Studies Puberty Recording of previous events Recruitment Activity Relative (related person)Research Research Design Risk Risk Factors Risk-Taking Sampling Sex Characteristics Short-Term Memory Staging Strategic Planning Stress Structure System Techniques Teenagers Temperament Testing Time Youth abstracting addiction alcohol effect alcohol exposure alcohol use disorder alcohol use initiation base binge drinking brain volume critical period design discounting drinking drinking behavior early alcohol abuse early alcohol use executive function follow-up heavy drinking during adolescence high risk high risk behavior neurodevelopment neuroimaging neuropsychological neurotoxic response sex white matter

项目摘要

Abstract: Adolescence is a developmental period during which individuals engage in risk-taking behavior and are likely to initiate use of alcohol or other drugs. Past research suggests a strong correlation between early age of onset of alcohol use and a heightened vulnerability to addiction later in life. Adolescence is also a time of considerable neuromaturation, particularly in frontal brain regions thought to subserve higher level cognition, such as decision making and inhibition. Heavy alcohol use during these critical periods of brain development may permanently disrupt the course of maturation, resulting in long-term deficits in these functions and thereby increasing the risk of subsequent substance use behavior. The proposed R01 project is designed to prospectively and longitudinally examine the influence of developmental stage on the effects of alcohol on adolescent cognition, brain functioning, and brain structure, using neuroimaging and neuropsychological testing techniques. This project will examine neuropsychological performance during tests of executive functioning, brain functioning during executive and risk taking fMRI tasks, brain structure in prefrontal and limbic regions, and frontostriatal white matter integrity in 250 at-risk, non-using 12-14-year-old youth (based on family history of alcoholism). We hypothesize that youth who drink in adolescence will show abnormalities on these measures compared to developmentally-matched non-drinking youth, and that youth who initiate heavy drinking earlier in puberty will show greater abnormalities than teens that initiate heavy drinking later in development. This prospective study will answer critical questions about how developmental timing of adolescent heavy alcohol use initiation affects the developing brain.

抽象的：青春期是一个发展时期，在此期间个体从事冒险行为并且可能开始使用酒精或其他药物。过去的研究表明，发病年龄早之间有很强的相关性酒精使用和晚年更容易上瘾。青春期也是一个时期相当大的神经成熟度，特别是在被认为有助于更高水平认知的额叶区域，例如决策和抑制。在大脑发育的关键时期大量饮酒可能会永久破坏成熟过程，导致这些功能的长期缺陷，从而增加后续物质使用行为的风险。拟议的 R01 项目旨在前瞻性和纵向研究发育阶段对酒精影响的影响利用神经影像学和神经心理学研究青少年认知、大脑功能和大脑结构测试技术。该项目将检查执行测试期间的神经心理学表现功能、执行和冒险功能磁共振成像任务期间的大脑功能、前额叶和 250 名处于危险中、不使用物品的 12-14 岁青少年的边缘区和额纹状体白质完整性（基于有酗酒家族史）。我们假设在青春期饮酒的青少年会表现出异常这些措施与发育相匹配的不饮酒青少年以及开始大量饮酒的青少年进行了比较在青春期较早饮酒的青少年比在青春期较晚开始大量饮酒的青少年表现出更大的异常发展。这项前瞻性研究将回答有关发育时间如何的关键问题青少年大量饮酒会影响发育中的大脑。