The TEEN Study: The Impact of Adolescent Drinking on Connectivity in the Brain

青少年研究：青少年饮酒对大脑连接的影响

• 批准号: 8413177
• 负责人: Bonnie J Nagel
• 金额: $ 57.86万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8413177
• 关键词: Adolescence; Adolescent; Age; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Appetitive Behavior; Architecture; Behavior; Behavioral; Brain; Characteristics; Clinical assessments; Cognition; Cognitive; Collaborations; Communities; Complement; Data; Data Analyses; Data Collection; Data Set; Deltastab; Detection; Development; Emotional; Ensure; Environmental Risk Factor; Exhibits; Family history of; Functional Magnetic Resonance Imaging; Functional disorder; Graph; Heavy Drinking; Image; Image Analysis; Individual; Informatics; Intervention; Longitudinal Studies; Machine Learning; Magnetic Resonance Imaging; Measures; Metric; Neurocognitive; Pattern; Personality; Phenotype; Prevention strategy; Property; Psychopathology; Recruitment Activity; Regulation; Rest; Risk; Risk Marker; Role; Site; Social Functioning; Structure; Subgroup; System; Techniques; Time; Work; Youth; adolescent alcohol exposure; alcohol effect; base; cognitive control; cohort; computerized data processing; density; design; drinking; drinking behavior; early onset; neural circuit; neurodevelopment; neuroimaging; neurotoxic; reduce adolescent alcohol; relating to nervous system; reward circuitry; segregation; social; theories; underage drinking; Adolescence; Adolescent; Age; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Appetitive Behavior; Architecture; Behavior; Behavioral; Brain; Characteristics; Clinical assessments; Cognition; Cognitive; Collaborations; Communities; Complement; Data; Data Analyses; Data Collection; Data Set; Deltastab; Detection; Development; Emotional; Ensure; Environmental Risk Factor; Exhibits; Family history of; Functional Magnetic Resonance Imaging; Functional disorder; Graph; Heavy Drinking; Image; Image Analysis; Individual; Informatics; Intervention; Longitudinal Studies; Machine Learning; Magnetic Resonance Imaging; Measures; Metric; Neurocognitive; Pattern; Personality; Phenotype; Prevention strategy; Property; Psychopathology; Recruitment Activity; Regulation; Rest; Risk; Risk Marker; Role; Site; Social Functioning; Structure; Subgroup; System; Techniques; Time; Work; Youth; adolescent alcohol exposure; alcohol effect; base; cognitive control; cohort; computerized data processing; density; design; drinking; drinking behavior; early onset; neural circuit; neurodevelopment; neuroimaging; neurotoxic; reduce adolescent alcohol; relating to nervous system; reward circuitry; segregation; social; theories; underage drinking

DESCRIPTION (provided by applicant): This application describes the contribution of the OHSU site to the data collection efforts of the consortium entitled, Tracking Ethanol's Effects on Neurodevelopment (TEEN), and the specific focus of the OHSU site on examining how alcohol impacts functional connectivity in the developing brain and whether connectivity patterns can be used to predict risk for alcoholism. It is well-established that adolescence is a time of dramatic maturation in the brain, paralleled by improvements in executive abilities, social functioning, and emotional regulation. More recently, it has become appreciated that functional network dynamics of the brain, subserving these improvements, also dramatically change over the adolescent years. This period of heightened plasticity coincides with greater vulnerability to neurotoxic alcohol effects, such that heavy alcohol exposure during adolescence may result in disruption to normally occurring maturation of neural circuitry. To examine this question, the approach of the TEEN consortium will be to disproportionately recruit individuals who are at elevated risk for alcohol use, based on personality features. This approach was chosen to ensure sufficient numbers of individuals who will transition from no use to use within the duration of this project, and also ensures sufficient numbers of individuals who are already drinking thereby enabling cross-sectional comparisons to complement the longitudinal studies. Using a sequential cohort design, the TEEN consortium will recruit 750 youth, stratified across three age-ranges: 12-15 years, 15-18 years, and 18-21 years, with each site recruiting and following 150 youth. A standardized set of neuroimaging, cognitive, and clinical assessments will be included and administered at baseline and at three one-year follow-ups. The major aims of the OHSU site proposal are toward understanding the influence of alcohol on adolescent brain circuitry and at delineating risk-related abnormalities in developing adolescent brain networks using multi-modal integration. Understanding the neural phenotypes associated with increased risk for alcoholism and the potentially deleterious impact of alcohol on the neural connections in the adolescent brain could aid in the development of targeted strategies aimed at reducing adolescent alcohol drinking behaviors. PUBLIC HEALTH RELEVANCE: The present study seeks to investigate the effect of adolescent drinking on the functional connectivity of the brain and determine whether patterns of connectivity can predict risk for heavy alcohol consumption. Isolating the effects of alcohol use and identifying risk markers is necessary to develop specifically targeted prevention and intervention strategies for youth.

描述（由申请人提供）：本申请描述了OHSU站点对标题为标题的财团的数据收集工作的贡献，跟踪乙醇对神经发育的影响（TEEN）以及OHSU站点的特定重点在研究酒精对发展中的功能连接性在发育中的功能连接以及是否可以使用连接模式来预测对酒精饮酒的风险。众所周知的是，青春期是大脑中戏剧性成熟的时期，与执行能力，社会功能和 情绪调节。最近，人们对大脑的功能网络动力学（在这些改进中取得进步）也发生了巨大变化，这在青少年时代也发生了巨大变化。这一增强的可塑性时期与神经毒性酒精作用更大的脆弱性一致，因此青春期的大量酒精暴露可能会导致正常发生神经回路的成熟。为了研究这个问题，青少年财团的方法是根据人格特征，招募饮酒风险较高的个人。选择这种方法是为了确保足够数量的个体从无用过渡到该项目的期限，并确保足够数量的人已经喝酒，从而实现了横断面比较以补充纵向研究。该青少年联盟使用连续的队列设计将招募750名青年，分层三个年龄段：12-15岁，15-18岁和18-21岁，每个网站招募和150名青年。将在基线和三年的随访中包括并进行一组标准化的神经影像学，认知和临床评估。 OHSU站点建议的主要目的是了解酒精对青少年脑电路的影响以及使用多模式整合开发青春期脑网络中与风险相关的异常。了解与酗酒风险增加有关的神经表型以及酒精对青少年大脑神经联系的潜在有害影响可能有助于开发旨在减少青少年酒精饮酒行为的有针对性策略。 公共卫生相关性：本研究旨在研究青少年饮酒对大脑功能连通性的影响，并确定连通性模式是否可以预测大量酒精消耗的风险。为了制定针对年轻人的专门针对的预防和干预策略，必须隔离饮酒和识别风险标记的影响。