Sex-specific trajectories of neurobiological maturation during adolescence

青春期神经生物学成熟的性别特异性轨迹

基本信息

批准号：
8443510
负责人：
Bonnie J Nagel
金额：
$ 23.1万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-01-18 至 2014-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8443510
关键词：
15 year old Adolescence Adolescent Adult Affective Age Back Behavior Behavioral Biological Assay Brain Brain region Characteristics Cognition Cognitive Corpus striatum structure Coupled Cross-Sectional Studies Decision Making Development Developmental Process Diffusion Magnetic Resonance Imaging Disease Down-Regulation Emotional Emotions Esthesia Female Female Adolescents Fiber Functional Magnetic Resonance Imaging Future Gonadal Hormones Hormonal Hormones Incidence Individual Individual Differences Knowledge Longitudinal Studies Magnetic Resonance Imaging Male Adolescents Mediating Mediator of activation protein Mental disorders Moods Motivation Neurobiology Neurocognitive Nucleus Accumbens Parietal Pathway interactions Personality Personality Assessment Personality Traits Play Prefrontal Cortex Prevention Process Psychopathology Puberty Regulation Rest Rewards Risk Role Serum Sex Characteristics Short-Term Memory Social Behavior Social Functioning Structure System Time Ursidae Family Variant Work age related base cognitive control cohort executive function improved longitudinal design male motivated behavior neurodevelopment neuroimaging public health relevance relating to nervous system resilience segregation sex skills treatment strategy white matter

项目摘要

DESCRIPTION (provided by applicant): It is well-established that adolescence is a time of dramatic neuromaturation, paralleled by improvements in cognition, social functioning, and emotional regulation. In addition, cross-sectional studies have demonstrated that rising gonadal hormone levels associated with puberty influence emotional and appetitive processing and limbic brain structure and functioning. Given the rise in psychopathology during adolescence, the hormonal activation of limbic brain regions during puberty, coupled with the immaturity of sexually dimorphic prefrontal regulatory systems, may contribute to heightened adolescent vulnerability for psychopathology in a sex- specific manner; however, little longitudinal work has been done to fully explore this notion. To that end, this study will longitudinally follow 120 healthy, 12-15-year-old male and female adolescents after one year with a rich, multimodal neuroimaging and behavioral characterization. This assessment will include functional neuroimaging during working memory and decision making, resting state functional neuroimaging, diffusion tensor imaging, neurocognitive assessment, mood/behavior/personality assessment, and serum hormone assays. Using a multi-modal longitudinal design, we aim to better understand sex-specific structural and functional neuromaturation of the brain during adolescence and to explore associations with gonadal hormones, cognition, and behavior. Increased understanding of these relationships may help to explain sex- specific vulnerability, better dissociate hormonally influenced developmental pathways from those that are not, elucidate individual characteristics conferring risk and resilience, and may ultimately permit the development of targeted treatment strategies aimed at reducing adolescent psychopathology.

描述（由申请人提供）：众所周知，青春期是神经急剧成熟的时期，同时认知、社会功能和情绪调节也得到改善。此外，横断面研究表明，与青春期相关的性腺激素水平升高会影响情绪和食欲处理以及边缘脑结构和功能。鉴于青春期精神病理学的兴起，青春期期间大脑边缘区域的激素激活，加上性二态性前额叶调节系统的不成熟，可能会导致青少年以性别特异性的方式更容易受到精神病理学的影响；然而，很少有纵向工作来充分探索这一概念。为此，这项研究将在一年后对 120 名健康的 12-15 岁男性和女性青少年进行纵向跟踪，并提供丰富的多模式神经影像和行为特征。该评估将包括工作记忆和决策过程中的功能性神经影像、静息态功能性神经影像、扩散张量成像、神经认知评估、情绪/行为/性格评估和血清激素测定。使用多模式纵向设计，我们的目标是更好地了解青春期期间大脑的性别特异性结构和功能神经成熟，并探索与性腺激素、认知和行为的关联。加深对这些关系的理解可能有助于解释性别特异性的脆弱性，更好地将受激素影响的发育途径与不受激素影响的发育途径区分开来，阐明赋予风险和复原力的个体特征，并可能最终允许制定旨在减少青少年精神病理学的有针对性的治疗策略。