Sex-specific trajectories of neurobiological maturation during adolescence

青春期神经生物学成熟的性别特异性轨迹

• 批准号: 8443510
• 负责人: Bonnie J Nagel
• 金额: $ 23.1万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-18 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8443510
• 关键词: 15 year old; Adolescence; Adolescent; Adult; Affective; Age; Back; Behavior; Behavioral; Biological Assay; Brain; Brain region; Characteristics; Cognition; Cognitive; Corpus striatum structure; Coupled; Cross-Sectional Studies; Decision Making; Development; Developmental Process; Diffusion Magnetic Resonance Imaging; Disease; Down-Regulation; Emotional; Emotions; Esthesia; Female; Female Adolescents; Fiber; Functional Magnetic Resonance Imaging; Future; Gonadal Hormones; Hormonal; Hormones; Incidence; Individual; Individual Differences; Knowledge; Longitudinal Studies; Magnetic Resonance Imaging; Male Adolescents; Mediating; Mediator of activation protein; Mental disorders; Moods; Motivation; Neurobiology; Neurocognitive; Nucleus Accumbens; Parietal; Pathway interactions; Personality; Personality Assessment; Personality Traits; Play; Prefrontal Cortex; Prevention; Process; Psychopathology; Puberty; Regulation; Rest; Rewards; Risk; Role; Serum; Sex Characteristics; Short-Term Memory; Social Behavior; Social Functioning; Structure; System; Time; Ursidae Family; Variant; Work; age related; base; cognitive control; cohort; executive function; improved; longitudinal design; male; motivated behavior; neurodevelopment; neuroimaging; public health relevance; relating to nervous system; resilience; segregation; sex; skills; treatment strategy; white matter

DESCRIPTION (provided by applicant): It is well-established that adolescence is a time of dramatic neuromaturation, paralleled by improvements in cognition, social functioning, and emotional regulation. In addition, cross-sectional studies have demonstrated that rising gonadal hormone levels associated with puberty influence emotional and appetitive processing and limbic brain structure and functioning. Given the rise in psychopathology during adolescence, the hormonal activation of limbic brain regions during puberty, coupled with the immaturity of sexually dimorphic prefrontal regulatory systems, may contribute to heightened adolescent vulnerability for psychopathology in a sex- specific manner; however, little longitudinal work has been done to fully explore this notion. To that end, this study will longitudinally follow 120 healthy, 12-15-year-old male and female adolescents after one year with a rich, multimodal neuroimaging and behavioral characterization. This assessment will include functional neuroimaging during working memory and decision making, resting state functional neuroimaging, diffusion tensor imaging, neurocognitive assessment, mood/behavior/personality assessment, and serum hormone assays. Using a multi-modal longitudinal design, we aim to better understand sex-specific structural and functional neuromaturation of the brain during adolescence and to explore associations with gonadal hormones, cognition, and behavior. Increased understanding of these relationships may help to explain sex- specific vulnerability, better dissociate hormonally influenced developmental pathways from those that are not, elucidate individual characteristics conferring risk and resilience, and may ultimately permit the development of targeted treatment strategies aimed at reducing adolescent psychopathology.

描述（由申请人提供）：良好的是，青春期是一个戏剧性神经饱和的时期，与认知，社会功能和情感调节的改善相似。此外，横断面研究表明，与青春期相关的性腺激素水平上升会影响情绪和开胃菜的加工以及边缘大脑结构和功能。鉴于青春期心理病理学的提高，青春期边缘大脑区域的激素激活，再加上性二态前额叶前额叶调节系统的不成熟，可能会导致以性别方式以性别病理学的增强精神病理学的青少年脆弱性；但是，几乎没有进行纵向工作来充分探索这个概念。为此，这项研究将在一年后纵向遵循120名健康的，12-15岁的男性和女性青少年，并具有丰富的多模式神经影像学和行为表征。该评估将包括在工作记忆和决策过程中的功能神经影像，静止状态功能神经成像，扩散张量成像，神经认知评估，情绪/行为/人格评估和血清激素测定法。使用多模式纵向设计，我们旨在更好地了解青春期大脑的性别特异性结构和功能性神经饱和，并探索与性腺激素，认知和行为的关联。对这些关系的越来越多可能有助于解释性别脆弱性，更好地将荷尔蒙影响的发育途径与没有的发展途径分离，阐明个人特征赋予风险和韧性，并最终允许制定旨在减少青少年精神病理学的有针对性治疗策略。