Transcranial Direct Current Stimulation for Cognitive Enhancement in FASD

经颅直流电刺激增强 FASD 认知能力

• 批准号: 8648843
• 负责人: Brian A Coffman
• 金额: $ 2.26万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8648843
• 关键词: Accounting; Adolescent; Affect; Alcohol-Related Neurodevelopmental Disorder; Attention; Auditory Hallucination; Behavior; Behavioral; Brain; Child; Clinical; Clinical Treatment; Cognitive; Cognitive deficits; Communication Research; Data; Decision Making; Development; Diagnosis; Disease; Effectiveness; Electrodes; Electroencephalography; Event-Related Potentials; Exhibits; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Functional disorder; Gambling; Goals; Impaired cognition; Impairment; Individual; Intervention; Lead; Learning; Live Birth; Location; Measures; Memory; Mental Depression; Methods; Metric; Motor; Outcome; Participant; Patients; Pilot Projects; Population; Prevalence; Process; Protocols documentation; Publishing; Relative (related person); Research; Research Personnel; Research Training; Risk; Sensory; Short-Term Memory; Stroke; Techniques; Testing; Therapeutic; Tinnitus; Training; United States; Verbal Learning; alcohol exposure; behavior measurement; career; clinically relevant; cognitive enhancement; cost; economic cost; effective intervention; experience; improved; life time cost; neuroimaging; neurophysiology; prenatal exposure; public health relevance; research clinical testing; research study; response; skills; training project; university student; young adult

DESCRIPTION (provided by applicant): The primary purpose of this proposed research training project is to enhance the applicant's ability to succeed in a research career in neuroimaging and neuromodulatory methods as they apply to clinical populations. The applicant will acquire important skills in acquisition and analysis of electroencephalography (EEG) data and the application of transcranial direct current stimulation (tDCS) in a clinical population. The proposed research also aims to examine the utility of an inexpensive, easily applied intervention technique (tDCS) for mitigation of cognitive dysfunction associated with Fetal Alcohol Spectrum Disorders (FASD). Recent behavioral and neuroimaging research from our lab and others has demonstrated diminished attention and increased risky decision making in participants with FASD compared to healthy controls. Interestingly, our lab and others have also recently found that these cognitive processes can be improved using tDCS. It is therefore hypothesized that tDCS may be useful for treatment of dysfunction in attention and risky decision making related to FASD. The most effective placement for tDCS enhancement of attention and reduction of risky decision making will first be determined using the sustained attention to response task and the Cambridge gambling task, respectively. Behavioral and EEG data will be used as a metric for the effectiveness of tDCS. Following this experiment in healthy controls, young adults with FASD will be examined using this/these tDCS electrode placements. By completing the aims outlined in this proposal, the applicant will learn methods for quantification and analysis of EEG data. He will also learn to utilize previous experience with tDCS in healthy participants for application to those with FASD, and the applicant will be trained in the planning, execution, and communication of research, with the goal of becoming an independent researcher. Results obtained in the experiments outlined in this proposal may be clinically relevant as well. It is expected that tDCS will produce strong behavioral and electrophysiological effects for both attention and risky decision making. The results of these experiments have the potential to provide a safe and inexpensive therapeutic technique for alleviating the effects of FASD.

描述（由申请人提供）：该拟议研究培训项目的主要目的是提高申请人在神经影像和神经调节方法应用于临床人群的研究生涯中取得成功的能力。申请人将获得脑电图（EEG）数据采集和分析以及经颅直流电刺激（tDCS）在临床人群中应用的重要技能。这 拟议的研究还旨在检验一种廉价、易于应用的干预技术（tDCS）在缓解与胎儿酒精谱系障碍（FASD）相关的认知功能障碍方面的效用。我们实验室和其他实验室最近的行为和神经影像学研究表明，与健康对照组相比，FASD 参与者的注意力减少，风险决策增加。有趣的是，我们的实验室和其他人最近也发现可以使用 tDCS 来改善这些认知过程。因此，推测 tDCS 可能有助于治疗与 FASD 相关的注意力功能障碍和危险决策。首先，分别使用对反应任务和剑桥赌博任务的持续注意力来确定 tDCS 增强注意力和减少风险决策的最有效布置。行为和脑电图数据将用作 tDCS 有效性的衡量标准。在健康对照中进行这项实验后，患有 FASD 的年轻人将使用此/这些 tDCS 电极放置进行检查。通过完成本提案中概述的目标，申请人将学习脑电图数据的量化和分析方法。他还将学习利用以前在健康参与者中进行 tDCS 的经验，应用于患有 FASD 的参与者，申请人将接受研究规划、执行和沟通方面的培训，目标是成为一名独立研究员。本提案中概述的实验中获得的结果也可能具有临床相关性。预计 tDCS 将为注意力和风险决策产生强烈的行为和电生理效应。这些实验的结果有可能为减轻 FASD 的影响提供一种安全且廉价的治疗技术。