Biostatistics

生物统计学

• 批准号: 8738894
• 负责人: Jane Meza
• 金额: $ 6.74万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-05 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8738894
• 关键词: Address; Animals; Archives; Biometry; Biostatistics Core; Biostatistics Shared Resource; Cancer Center; Characteristics; Clinical Research; Clinical Trials; Complex; Conduct Clinical Trials; Data; Data Analyses; Data Quality; Databases; Development; Doctor of Philosophy; Ensure; Faculty; Housing; Laboratories; Lead; Malignant neoplasm of pancreas; Manuscripts; Monitor; Monitoring Clinical Trials; Patients; Public Health; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resources; Robin bird; Specific qualifier value; Training; Work; abstracting; base; college; data acquisition; data management; design; human subject; improved; meetings; member; patient safety; success

The purpose of the Biostatistics Core is to collaborate with SPORE investigators on their research projects and to monitor the conduct of the clinical trials. Specifically, the Biostatistics Core will develop statistical designs, develop statistical analysis plans, perform data acquisition, develop databases, archive data, develop clinical research forms, perform data monitoring for clinical trials involving human subjects, perform data analysis and interpretation and aid in the development of manuscripts, abstracts and presentations. This purpose will be accomplished through the following specific aims: 1) Collaborate with SPORE investigators on study design to develop projects with appropriate statistical operating characteristics 2) Provide a statistical analysis plan for each SPORE project 3) Perform statistical analyses of project results as specified in the statistical analysis plan and collaborate with SPORE investigators on the interpretation and reporting of research findings 4) Monitor the conduct of SPORE clinical research projects to ensure patient safety and the scientific integrity of the projects 5) Collaborate with SPORE investigators on interpretation of data analysis results and aid in the development of manuscripts, abstracts and presentations. A team of two faculty and two Masters-trained biostatisticians has been assembled to meet the range of statistical methodological and analytical needs of the projects, including expertise in design and analysis of high-dimensional data and clinical trials. This team will ensure that the design and analyses are appropriate to meet the aims of the projects, which is essential to the success of the SPORE. The Biostatistics Core will be directed by Jane Meza Ph.D. and additionally staffed by Fang Yu Ph.D. (specializing in high-dimensional data analysis), Lynette Smith M.S. (Masters-trained biostatistician specializing in high-dimensional data analysis) and Robin High M.A. (Masters-trained biostatistician).

生物统计学核心的目的是与 SPORE 研究人员合作开展他们的研究项目 并监督临床试验的进行。具体来说，生物统计核心将开发统计 设计、制定统计分析计划、执行数据采集、开发数据库、归档数据、 开发临床研究表格，对涉及人体受试者的临床试验进行数据监测，执行 数据分析和解释以及帮助编写手稿、摘要和演示文稿。 这一目的将通过以下具体目标来实现：1) 与 SPORE 合作 研究者进行研究设计，以开发具有适当统计操作特征的项目 2) 为每个SPORE项目提供统计分析计划 3) 对项目结果进行统计分析 按照统计分析计划中的规定，并与 SPORE 研究人员合作进行解释 和报告研究结果 4) 监督 SPORE 临床研究项目的进行，以确保 患者安全和项目的科学完整性 5) 与 SPORE 研究人员合作 解释数据分析结果并帮助编写手稿、摘要和 演示文稿。 一支由两名教员和两名受过硕士学位的生物统计学家组成的团队已经组建起来，以满足一系列的要求 项目的统计方法和分析需求，包括设计和分析方面的专业知识 高维数据和临床试验。该团队将确保设计和分析是适当的 实现项目目标，这对于 SPORE 的成功至关重要。生物统计学核心将 由 Jane Meza 博士指导另外还有余芳博士。 （专门从事高维 数据分析），Lynette Smith M.S. （经过硕士培训的生物统计学家，专门研究高维数据 分析）和 Robin High M.A.（经过硕士培训的生物统计学家）。