Mouse Phenotyping Informatics Infrastruture - MP12

小鼠表型信息学基础设施 - MP12

• 批准号: 8875284
• 负责人: Steve Brown
• 金额: $ 15万
• 依托单位: EUROPEAN MOLECULAR BIOLOGY LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8875284
• 关键词: Archives; Area; Biological; Biological Assay; Biological Models; Biomedical Research; CXCL2 gene; Clinical Research; Communities; Complex; Data; Data Analyses; Data Coordinating Center; Data Display; Data Set; Data Sources; Databases; Deposition; Development; Ensure; Environment; Foundations; Future; Generations; Genetic; Genome; Genomics; Goals; Health; Human; Informatics; Institutes; Internet; Investigation; Life; Mining; Modeling; Mus; Mutagenesis; Mutant Strains Mice; Pathway interactions; Phenotype; Procedures; Process; Production; Qualifying; Quality Control; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Specialist; Staging; System; Testing; The Jackson Laboratory; Trust; United States National Institutes of Health; Validation; computerized data processing; data management; design; flexibility; gene function; genome wide association study; human disease; interest; mouse model; mutant; prevent; programs; prototype; tool

DESCRIPTION (provided by applicant): The K0MP2 data are a critical resource for biomedical research, will inform human disease studies, be integrated with existing resources and will be accessed, analyzed and mined by mouse biologists, translational researchers, clinicians and wider biomedical community. The MIP2 project will support the K0MP2 project by providing the Data Coordination Centre which will process the complex phenotypic data provide access via a web portal. The DCC aims are to collect and store valid data as it appears throughout the project, to provide unified access to these data for specialist and non specialist users via the web and programmatically, and to support complex queries and statistical analyses. The project has several distinct components and tasks: The Pheno-DCC will validate, perform quality control and manage data acquired dynamically from centres. This will ensure data are robust and allow progress tracking of data at all stages of processing. Specialist data wranglers will manage this process and will interact with the users of the data to ensure user interfaces support the needs of the varied community who will access these data. The statistical and annotation pipelines and environment which will analyze raw data and summarize data for each mutant and assay for presentation to users. A supporting core database, the Core Data Archive, which will store all project data, provide programmatic access, push data to external resources such as NCBI and the Jackson Laboratory and critically provide data for the user interfaces. A single point of entry web portal hosted at www.knockoutmouse.org which will present data to users. I, integrate data from parallel mouse phenotyping projects and provide access to a statistical analysis and query environment Integrate K0MP2 data via biomedical databases at the EBI to ensure that the data are widely distributed to mouse biologists and other scientists .

描述（由申请人提供）：K0MP2数据是生物医学研究的关键资源，将为人类疾病研究提供信息，与现有资源集成，并将由小鼠生物学家，转化研究人员，临床医生和更广泛的生物医学界访问，分析和开采。 MIP2项目将通过提供数据协调中心来支持K0MP2项目，该数据协调中心将处理复杂的表型数据通过Web门户提供访问。 DCC的目标是在整个项目中收集和存储有效的数据，以通过网络和编程方式为专家和非专家用户提供对这些数据的统一访问，并支持复杂的查询和统计分析。该项目具有几个不同的组件和任务：Pheno-DCC将验证，执行质量控制并从中心动态获得数据。这将确保数据稳健，并允许在处理的所有阶段对数据进行进度跟踪。专业数据牧马人将管理此过程，并将与数据用户进行交互，以确保用户界面支持将访问这些数据的各种社区的需求。 统计和注释管道和环境将分析原始数据并总结每个突变体的数据，并分析向用户介绍。 支持核心数据库的核心数据存档将存储所有项目数据，提供程序化访问，将数据推向外部资源，例如NCBI和Jackson Laboratory，并为用户界面提供严格的数据。 一个单个入口Web门户网站托管在www.knockoutmouse.org上，它将向用户呈现数据。 i，整合了平行小鼠表型项目的数据，并提供对统计分析和查询环境的访问，通过EBI的生物医学数据库集成了K0MP2数据，以确保数据广泛分配给小鼠生物学家和其他科学家。