Biomarker Collection and Analysis Core

生物标志物收集和分析核心

• 批准号: 8727690
• 负责人: Teresa E SEEMAN
• 金额: $ 21.36万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8727690
• 关键词: Address; Adherence; Aging; Atherosclerosis; Benchmarking; Biological; Biological Markers; Blood Pressure; Centers for Population Health; Clinic; Collection; Communities; Community Actions; Community Developments; Consult; County; Data; Data Analyses; Data Collection; Data Quality; Development; Disease; Emergency Medicine; Ensure; Faculty; Family; Family health status; Foundations; Geriatrics; Glycosylated Hemoglobin; Goals; Health; Health Services Research; Health Surveys; Indonesia; Information Systems; Internal Medicine; Intervention Studies; Intervention Trial; LDL Cholesterol Lipoproteins; Los Angeles; Measures; Metric; Mexican; National Health and Nutrition Examination Survey; Neighborhoods; Observational Study; Operations Research; Population; Process; Production; Proteins; Protocols documentation; Psychiatry; Quality Control; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Running; Services; Stroke; Stroke prevention; Structure; Surveys; System; TimeLine; Training and Education; United States; base; biodemography; community setting; computerized data processing; data management; experience; health disparity; indexing; medical schools; outreach; programs; software systems; success; web site

The overarching goal of Core C ("Biomarker Collection & Analysis Core") is to provide a centralized resource where SPIRP Center faculty and affiliates can go to obtain high-quality data collection and data management advice and assistance to support optimal research on stroke disparities. Core C builds on a foundation of extensive prior experience in biomarker (and other data) collecfion, processing, management and analysis, and leverages expertise in engagement with communities that typify health disparity populations in the most diverse county within the United States. Core C faculty have previously developed similar, highly successful research operafions cores and bring an extensive and successful track record of executing communitybased observational and intervention research. Core C will leverage this prior experience and expertise to accomplish the following Specific Aims: (1). Support biomarker data collection for the two intervention trials, Projects 1 & 3, including facilitating development and implementation of all data collecfion and data processing protocols for planned biomarkers, and collaborating with Core A to integrate proposed Core C data collection and data management acfivifies within the SPIRP's global IT and web site infrastructure; (2) Provide expert consulting for biomarker data analysis for Projects 1, 2 and 3, drawing on expertise in analysis of biomarker data to assist all proposed SPIRP projects with review of raw data, needed data transformations, implementation of analyses and interpretafion of results; (3). Collaborate with Core B to provide training and education for junior invesfigators and community stakeholders, contributing expertise to the production of materials on topics related to collection and interpretation of biomarkers; ^ (4). Establish metrics to assess progress of Specific Aims 1, 2 & 3, following a pre-estaBlished timeline for define benchmarks to measure adherence to Core goals, assess operational efficiency, and generate strategies for continuous improvement. f The overarching goal of Core C is to contribute to the success of the overall SPIRP Center by advising and assisfing SPIRP researchers in optimizing data collection and data management systems for their respective studies to ensure the highest quality data for addressing critical research questions.

Core C（“生物标志物收集和分析核心”）的总体目标是提供集中资源 Spip Center教师和分支机构可以获取高质量的数据收集和数据管理 建议和协助以支持有关中风差异的最佳研究。核心C建立在 在生物标志物（和其他数据）中的丰富经验，处理，管理和分析， 并利用与最多代表健康差异人群的社区参与的专业知识 美国境内的多元化县。核心教师以前已经发展了相似的，非常成功的 研究操作核心，并带来了执行社区的广泛而成功的记录 观察和干预研究。核心C将利用这种先前的经验和专业知识 完成以下特定目标： （1）。支持两个干预试验的生物标志物数据收集项目1和3，包括促进 计划已计划的所有数据集合和数据处理协议的制定和实施 生物标志物，并与核心A合作以整合提出的核心C数据收集和数据 在SPERP的全球IT和网站基础架构中，管理人员会提供分类； （2）为项目1、2和3提供专业咨询，以进行生物标志物数据分析，并利用专业知识 分析生物标志物数据，以帮助所有提出的SPERP项目，并审查原始数据，所需的数据 转换，分析的实施和结果解释； （3）。与Core B合作，为初级入侵者和社区提供培训和教育 利益相关者，为与收集有关的主题生产材料的生产贡献专业知识 生物标志物的解释； ^ （4）。建立指标以评估特定目的1、2和3的进度，之后是预先建立的时间表 定义基准测量以衡量遵守核心目标，评估运营效率并产生 持续改进的策略。 f 核心C的总体目标是通过建议为整个螺旋中心的成功做出贡献 并在其优化数据收集和数据管理系统方面提高SPERP 各自的研究，以确保解决关键研究问题的最高质量数据。