Consequences of Adolescent Substance Use on the Development of Impulse Control

青少年药物使用对冲动控制发展的影响

• 批准号: 8433399
• 负责人: Donald M Dougherty
• 金额: $ 56.58万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8433399
• 关键词: 12 year old; Address; Adolescence; Adolescent; Adolescent Development; Adult; Affect; Age; Aggressive behavior; Alcohol or Other Drugs use; Behavioral; Biological; Childhood; Complex; Development; Environmental Risk Factor; Etiology; Family history of; Goals; Growth; Impulsive Behavior; Individual Differences; Interview; Knowledge; Laboratories; Lead; Longitudinal Studies; Methods; Modeling; Monitor; National Institute of Drug Abuse; National Institute of Mental Health; Neurologic; Outcome; Parents; Patient Self-Report; Pattern; Predisposing Factor; Prevention program; Procedures; Process; Recruitment Activity; Relative (related person); Reporting; Research; Research Design; Risk; Risk Factors; Sampling; Strategic Planning; Substance Use Disorder; Testing; Theoretical model; United States National Institutes of Health; adolescent substance use; behavior measurement; boys; cohort; critical period; design; early adolescence; early onset; early onset substance use; environmental stressor; girls; improved; longitudinal design; population based; public health relevance; social; theories

DESCRIPTION (provided by applicant): Adolescence is a critical period of neurological, biological, and social growth during the transition from childhood to adulthood. Healthy adolescence is defined by an increasing ability to control impulsive behavior. Deviations from normal development that are produced by substance use and environmental factors are thought to contribute to poor impulse control. Preadolescent problems with impulse control and family histories of substance use disorders appear to increase the risk of earlier substance use initiation during adolescence. It is unknown whether poor impulse control contributes to, or is the result of, substance use and whether poor impulse control and substance use interact across adolescent development to produce increasingly negative outcomes. During a 5-year longitudinal study, we will determine how preadolescent impulse control predicts, and/or later substance use involvement alters, development of adolescent impulse control. We will recruit 360 preadolescent boys and girls (ages 10-12) with and without family histories of substance use disorders, none of whom have initiated regular substance use. Adolescents will complete assessments at study entry and again every 6 months through middle adolescence (from ages 10 through 17), when the risk of developing substance use is heightened. We will monitor changes in substance use involvement, environmental stressors, physical maturation, and impulse control. The project will examine these complex developmental influences on impulse control and substance use involvement by: (1) determining to what extent preadolescent levels of impulse control differ as a function of family history of substance use disorders; (2) determining to what extent preadolescent levels of impulse control predict regular substance use; (3) characterizing impulse control of normal adolescence, and how this development differs with varying levels of substance use; (4) determining how the development of impulse control among substance users is related to the progression of substance use involvement; (5) determining the relative influence of family histories of substance use disorders, substance use involvement, environmental stressors, and maturation on impulse control development across adolescence; (6) determining if there is a reciprocal relationship between impulse control and substance use involvement, such that they have increasingly negative behavioral outcomes that affect each other during adolescence; and (7) testing the relationships of impulse control, family history of substance use disorders, environmental stressors, and substance use involvement within the context of two leading models. By carrying out these aims, we will determine when, how, and to what extent individual differences in these factors contribute to the initiation and progression of substance use; how subsequent substance use affects development of impulse control; and whether our findings support two leading theoretical models of adolescent substance use involvement.

描述（由申请人提供）：青春期是从童年到成年过渡期间神经、生物和社会性成长的关键时期。健康的青春期是指控制冲动行为的能力不断增强。物质使用和环境因素造成的正常发育偏差被认为是导致冲动控制不良的原因。青春期前的冲动控制问题和物质使用障碍家族史似乎增加了青春期早期开始物质使用的风险。目前尚不清楚不良的冲动控制是否会导致物质使用，或者不良的冲动控制和物质使用是否会在青少年的发展过程中相互作用，从而产生越来越负面的结果。在一项为期 5 年的纵向研究中，我们将确定青春期前的冲动控制如何预测和/或后期的物质使用参与如何改变青春期冲动控制的发展。我们将招募 360 名青春期前的男孩和女孩（10-12 岁），他们有或没有药物使用障碍家族史，他们中没有人开始定期使用药物。青少年将在进入研究时完成评估，并在青春期中期（从 10 岁到 17 岁）每 6 个月完成一次评估，此时药物滥用的风险会增加。我们将监测物质使用参与、环境压力源、身体成熟度和冲动控制的变化。该项目将通过以下方式研究这些复杂的发育对冲动控制和物质使用参与的影响：（1）确定青春期前冲动控制水平作为物质使用障碍家族史的函数的差异程度； (2) 确定青春期前的冲动控制水平在多大程度上可以预测正常的物质使用； (3) 描述正常青春期冲动控制的特征，以及这种发展如何随着物质使用水平的不同而不同； (4) 确定物质使用者冲动控制的发展与物质使用参与的进展有何关系； (5) 确定物质使用障碍家族史、物质使用参与、环境压力源和成熟度对整个青春期冲动控制发展的相对影响； (6) 确定冲动控制和物质使用参与之间是否存在相互关系，从而使它们在青春期期间产生越来越负面的行为结果，并相互影响； (7) 在两个主要模型的背景下测试冲动控制、物质使用障碍家族史、环境压力源和物质使用参与之间的关系。通过实现这些目标，我们将确定这些因素的个体差异何时、如何以及在多大程度上促成物质使用的开始和发展；随后的物质使用如何影响冲动控制的发展；以及我们的研究结果是否支持青少年物质使用参与的两种主要理论模型。