Consequences of Adolescent Substance Use on the Development of Impulse Control

青少年药物使用对冲动控制发展的影响

• 批准号: 8433399
• 负责人: Donald M Dougherty
• 金额: $ 56.58万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8433399
• 关键词: 12 year old; Address; Adolescence; Adolescent; Adolescent Development; Adult; Affect; Age; Aggressive behavior; Alcohol or Other Drugs use; Behavioral; Biological; Childhood; Complex; Development; Environmental Risk Factor; Etiology; Family history of; Goals; Growth; Impulsive Behavior; Individual Differences; Interview; Knowledge; Laboratories; Lead; Longitudinal Studies; Methods; Modeling; Monitor; National Institute of Drug Abuse; National Institute of Mental Health; Neurologic; Outcome; Parents; Patient Self-Report; Pattern; Predisposing Factor; Prevention program; Procedures; Process; Recruitment Activity; Relative (related person); Reporting; Research; Research Design; Risk; Risk Factors; Sampling; Strategic Planning; Substance Use Disorder; Testing; Theoretical model; United States National Institutes of Health; adolescent substance use; behavior measurement; boys; cohort; critical period; design; early adolescence; early onset; early onset substance use; environmental stressor; girls; improved; longitudinal design; population based; public health relevance; social; theories

DESCRIPTION (provided by applicant): Adolescence is a critical period of neurological, biological, and social growth during the transition from childhood to adulthood. Healthy adolescence is defined by an increasing ability to control impulsive behavior. Deviations from normal development that are produced by substance use and environmental factors are thought to contribute to poor impulse control. Preadolescent problems with impulse control and family histories of substance use disorders appear to increase the risk of earlier substance use initiation during adolescence. It is unknown whether poor impulse control contributes to, or is the result of, substance use and whether poor impulse control and substance use interact across adolescent development to produce increasingly negative outcomes. During a 5-year longitudinal study, we will determine how preadolescent impulse control predicts, and/or later substance use involvement alters, development of adolescent impulse control. We will recruit 360 preadolescent boys and girls (ages 10-12) with and without family histories of substance use disorders, none of whom have initiated regular substance use. Adolescents will complete assessments at study entry and again every 6 months through middle adolescence (from ages 10 through 17), when the risk of developing substance use is heightened. We will monitor changes in substance use involvement, environmental stressors, physical maturation, and impulse control. The project will examine these complex developmental influences on impulse control and substance use involvement by: (1) determining to what extent preadolescent levels of impulse control differ as a function of family history of substance use disorders; (2) determining to what extent preadolescent levels of impulse control predict regular substance use; (3) characterizing impulse control of normal adolescence, and how this development differs with varying levels of substance use; (4) determining how the development of impulse control among substance users is related to the progression of substance use involvement; (5) determining the relative influence of family histories of substance use disorders, substance use involvement, environmental stressors, and maturation on impulse control development across adolescence; (6) determining if there is a reciprocal relationship between impulse control and substance use involvement, such that they have increasingly negative behavioral outcomes that affect each other during adolescence; and (7) testing the relationships of impulse control, family history of substance use disorders, environmental stressors, and substance use involvement within the context of two leading models. By carrying out these aims, we will determine when, how, and to what extent individual differences in these factors contribute to the initiation and progression of substance use; how subsequent substance use affects development of impulse control; and whether our findings support two leading theoretical models of adolescent substance use involvement.

描述（由申请人提供）：青春期是从童年到成年期过渡期间神经，生物学和社会成长的关键时期。健康的青春期是由控制冲动行为的越来越多的能力来定义的。通过使用物质使用和环境因素产生的正常发育的偏差被认为会导致脉冲控制不良。脉冲控制和药物使用障碍的家庭历史的前质问题似乎增加了青春期早期使用物质使用的风险。尚不清楚脉冲控制差是使用物质的结果，还是造成药物使用的结果，以及在青少年发育中脉冲控制和药物使用是否相互作用，以产生越来越多的负面结果。在一项为期5年的纵向研究中，我们将确定前脉冲控制如何预测和/或以后的物质使用参与变化，发展青少年脉冲控制的发展。我们将招募360名预种族前的男孩和女孩（10-12岁），有或没有家庭使用障碍的家庭历史，他们都没有定期使用药物。青少年将在研究进入时完成评估，每6个月至青春期中（从10至17岁）再次完成评估，当时有升高的物质使用风险。我们将监视物质使用参与，环境压力源，身体成熟和冲动控制的变化。该项目将研究这些复杂的发育影响对脉冲控制和物质使用参与的影响：（1）确定在多大程度上，脉冲控制水平在多大程度上因物质使用障碍的家族史而有所不同； （2）确定在多大程度上脉冲控制水平预测常规物质的使用； （3）表征对正常青春期的冲动控制，以及这种发展与使用水平的不同； （4）确定药物使用者之间脉冲控制的发展与药物使用参与的进展如何； （5）确定物质使用障碍的家庭历史，物质使用参与，环境压力源和成熟对整个青春期冲动控制发展的相对影响； （6）确定脉冲控制和吸毒的参与之间是否存在相互关系，以使它们具有越来越多的负面行为结果，在青春期中相互影响； （7）测试冲动控制，物质使用障碍的家族史，环境压力源和物质使用参与的关系。通过执行这些目标，我们将确定这些因素中的个体差异何时，如何以及在何种程度上有助于吸毒的开始和进展；随后的物质使用如何影响冲动控制的发展；以及我们的发现是否支持两个领先的青少年物质使用参与的理论模型。