Improving Remote Breathalyzer Procedures used by Clinicians and Researchers to Remotely Monitor Alcohol Use

改进临床医生和研究人员用于远程监测酒精使用情况的远程呼吸分析仪程序

基本信息

批准号：
10670837
负责人：
Donald M Dougherty
金额：
$ 18.96万
依托单位：
UNIVERSITY OF NORTH TEXAS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10670837
关键词：
Abstinence Adopted Adoption Alcohol consumption Alcohols Area Behavior Therapy Biological Markers Blood Blood alcohol level measurement Blood specimen Breath Tests Clinical Data Detection Devices Disadvantaged Effectiveness Event Excretory function Face Failure Forensic Medicine Frequencies Future Health Technology Heavy Drinking Hour Incentives Individual Intervention Manufacturer Measurement Measures Methods Monitor Motivation National Institute on Alcohol Abuse and Alcoholism Participant Pattern Periodicals Persons Physical activity Procedures Protocols documentation Public Health Recommendation Reporting Research Research Personnel Sampling Secure Skin Sleep Specificity Spottings Strategic Planning Testing Text Messaging Time Violence Waiting Lists Work alcohol measurement alcohol monitoring breath alcohol measurement clinical practice contingency management cost drinking driving under influence dual diagnosis eHealth handheld mobile device improved liver transplantation offender phosphatidylethanol recruit remote monitoring secondary analysis social stigma wearable sensor technology

Abstinence Adopted Adoption Alcohol consumption Alcohols Area Behavior Therapy Biological Markers Blood Blood alcohol level measurement Blood specimen Breath Tests Clinical Data Detection Devices Disadvantaged Effectiveness Event Excretory function Face Failure Forensic Medicine Frequencies Future Health Technology Heavy Drinking Hour Incentives Individual Intervention Manufacturer Measurement Measures Methods Monitor Motivation National Institute on Alcohol Abuse and Alcoholism Participant Pattern Periodicals Persons Physical activity Procedures Protocols documentation Public Health Recommendation Reporting Research Research Personnel Sampling Secure Skin Sleep Specificity Spottings Strategic Planning Testing Text Messaging Time Violence Waiting Lists Work alcohol measurement alcohol monitoring breath alcohol measurement clinical practice contingency management cost drinking driving under influence dual diagnosis eHealth handheld mobile device improved liver transplantation offender phosphatidylethanol recruit remote monitoring secondary analysis social stigma wearable sensor technology

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项目摘要

Project Summary/Abstract The availability of wearable biosensors that continuously and/or remotely monitor alcohol use is increasing and has created new opportunities for research and intervention in clinical practice and forensic settings. Our previous work in this area has focused on transdermal alcohol monitors, which remotely and continuously monitor alcohol excreted through the skin. While such devices, like Secure Continuous Remote Alcohol Monitors, have been validated and found reliable, they have some disadvantages that limit widespread adoption including availability, cost, size, interference with physical activities, and stigma. One alternative is the use of breathalyzers that remotely sample and report breath alcohol levels across the day. These are becoming the preferred method for monitoring alcohol use in settings where continuous monitoring for alcohol consumption is required. Although remote breathalyzers are accurate for detecting current blood alcohol levels and identifying the individual providing the sample through facial recognition, their primary limitation could be the failure to detect drinking when monitoring is absent during the "off- cycle”; the 10 hours between early 9pm and 6am when heavy alcohol use could occur. Individuals who have difficulty remaining abstinent and may adopt a pattern of drinking during “off-cycle” periods to avoid the negative consequences associated with positive breath samples. We propose that current practices for remote alcohol breath monitoring in research, clinical, and judicial settings are inadequate to detect drinking. Specifically, we aim to evaluate the accuracy of remote breath alcohol monitoring to detect drinking events; and determine if drinking undetected by remote breath alcohol monitoring can be identified by phosphatidylethanol measurement. We expect that breath alcohol monitoring (and infrequent blood spot sampling) will be more acceptable than transdermal alcohol monitoring. This work challenges current practices by providing evidence of “off-cycle” drinking (Aim 1) and will improve existing methods by validating remote breath testing plus periodic measures of phosphatidylethanol (Aim 2). We also will determine the optimal frequency of phosphatidylethanol measurements to confidently confirm abstinence or identify those who may be motivated to adopt patterns of drinking to avoid detection and consequences (Aim 2). This work will help redefine remote alcohol-use monitoring procedures and significantly improve clinical, forensic and research practices.

项目摘要/摘要连续和/或远程监测酒精使用的可穿戴生物传感器的可用性是增加并为研究和干预临床实践和法医创造了新的机会设置。我们以前在该领域的工作集中于透皮酒精监测仪，这些监测器远程通过皮肤连续监测酒精独家。而这样的设备，例如安全连续远程酒精监视器已得到验证并发现可靠，他们有一些灾难限制宽度采用，包括可用性，成本，大小，对体育活动的干扰和污名。一替代方法是使用Breedalyzer远程品尝和报告全天呼吸饮酒水平。这些正在成为监视酒精使用的首选方法，以持续需要监视饮酒。虽然远程育种者很准确地检测当前的血液酒精水平并通过面部识别来确定个人提供样本，他们的主要局限性可能是在“离线”期间缺乏监测时无法检测到饮酒周期”；当可能发生大量饮酒时，在晚上9点至凌晨6点之间的10个小时。避免戒酒的困难，可能会在“偏离周期”期间采取饮酒方式，以避免与正呼吸样本相关的负面后果。我们建议目前的实践研究，临床和司法环境中的远程酒精呼吸监测不足以检测饮酒。具体而言，我们旨在评估远程呼吸酒精监测的准确性以检测饮酒事件；并确定是否可以通过远程呼吸饮酒监测来确定饮酒是否可以通过磷脂酰乙醇的测量。我们希望呼吸酒精监测采样）比透皮酒精监测更容易接受。这项工作挑战了当前通过提供“非周期”饮酒的证据（目标1），并将通过验证远程呼吸测试以及磷脂酰乙醇的定期测量（AIM 2）。我们也会确定磷脂酰乙醇测量的最佳频率，以确认戒酒或确定那些可能有动力采用饮酒模式以避免发现和后果的人（目标2）。这项工作将有助于重新定义远程酒精使用的监控程序，并大大改善临床，法医和研究实践。