Neurobehavioral and fMRI Research in HIV Infection and Cocaine Dependence
HIV 感染和可卡因依赖的神经行为和功能磁共振成像研究
基本信息
- 批准号:8471433
- 负责人:
- 金额:$ 1.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-03-01 至 2015-02-28
- 项目状态:已结题
- 来源:
- 关键词:AIDS neuropathyAIDS/HIV problemAcquired Immunodeficiency SyndromeAdultAffectAmericanAreaAttentionBehavioralBehavioral SciencesBilateralBrainCD4 Lymphocyte CountClinicalCocaineCocaine AbuseCocaine DependenceCognitiveCognitive deficitsCorpus striatum structureData AnalysesDecision MakingDevelopmentDiseaseDisease ProgressionDorsalDrug AddictionDrug abuseDrug userEarly identificationEducational workshopEnvironmentEquationFunctional Magnetic Resonance ImagingFunctional disorderFutureGamblingGoalsHIVHIV InfectionsHealthHigh PrevalenceImpairmentImpulsive BehaviorImpulsivityInfectionInstitutesInterdisciplinary StudyInternationalInterventionLearningLicensingLifeLightMagnetic Resonance ImagingMeasuresMediatingMemoryMentored Patient-Oriented Research Career Development AwardMentorsMentorshipMethamphetamineMethodologyMidbrain structureModelingMotorNatureNeurobiologyNeurocognitiveNeuropsychologyOutcomeParietalParticipantPatient Self-ReportPatientsPatternPerformancePersonsPopulationPrefrontal CortexPreventionPsychologistRecruitment ActivityResearchResearch MethodologyResearch PersonnelResearch TrainingRiskRisk BehaviorsRisk-TakingSamplingStructureSumTechniquesTestingTrainingTranslatingUnited StatesUniversitiesUnsafe SexVisual attentionaddictionbehavior measurementbehavioral impairmentcareer developmentclinical practicecognitive neurosciencecomparison groupdesigndrug abuserexecutive functionhigh riskimprovedinnovationmemory processneurobehavioralneurocognitive testneuroimagingneuropsychiatrynon-drugnovelpatient oriented researchprocessing speedprogramsrelating to nervous systemresearch studyskillsstatisticsstimulant abusesymposiumtreatment adherenceworking group
项目摘要
DESCRIPTION (provided by applicant): Neurobehavioral and fMRI Research in HIV Infection and Cocaine Dependence Dr. Christina Meade's long-term goal is to establish an independent and productive program of patient-oriented research dedicated to understanding the impact of drug abuse on behavioral and clinical outcomes in persons living with or at risk for HIV/AIDS. This application presents integrated training and research plans focused on HIV neurobehavioral dysfunction. The guiding hypothesis is that co-occurring HIV infection and cocaine dependence is associated with greater neurocognitive impairment and behavioral risk compared to each disease independently. As the fields of HIV/AIDS and drug abuse evolve, transdisciplinary research has the potential to accelerate advances in the prevention and treatment of these neuropsychiatric diseases. Therefore, Dr. Meade, a licensed clinical psychologist with a strong behavioral science background in HIV/AIDS and drug abuse, aims to develop expertise in cognitive neuroscience. Specifically, she seeks advanced training in: (1) neuroAIDS and neurocognitive assessment; (2) functional magnetic resonance imaging (fMRI); (3) brain circuitry relevant to addiction and neuroAIDS; and (4) longitudinal data analysis with repeated measures and latent variables. The training plan includes didactic coursework and workshops, one- on-one mentorship, participation in working groups and seminars, and attendance at national and international conferences. Consistent with the transdisciplinary nature of the proposed research, a mentorship team with distinct but complementary areas of expertise has been assembled: Drs. Scott Huettel (fMRI and executive function), Kevin Robertson (neuroAIDS and neuropsychology), Joseph McClernon (addiction and neuroimaging), Kathleen Sikkema (behavioral aspects of HIV), Rick Hoyle (statistics and methodology), and Roger Weiss (drug addiction). Duke University provides a rich environment in which Dr. Meade's career development goals can be readily accomplished, including access to state-of-the-art neuroimaging facilities, clinical units supportive of patient-oriented research, graduate-level courses in fMRI, statistics, and neurobiology, and several directly relevant interdisciplinary research centers and institutes. The research plan has been carefully designed to parallel the training plan; for each training goal there is a corresponding research directive that will allow Dr. Meade to implement newly developed skills. Both HIV infection and stimulant abuse affect neurocognitive functioning, yet few studies have empirically examined the effects of co- occurring HIV infection and stimulant abuse on neurobehavioral outcomes. This is an important research topic due to the high prevalence of co-occurring HIV infection and stimulant abuse, and the high rates of risky and impulsive behavior in this population. The research plan has 2 studies with the following specific aims: (1) identify patterns of neurocognitive impairment in HIV infection and cocaine dependence, and test whether these are associated with risky decision making and behavioral risk; and (2) examine brain activation patterns associated with attention and decision making as a function of HIV disease progression and co-occurring versus independent HIV infection and cocaine dependence. A sample of 160 patients will be recruited for a 3- group comparison study of persons with co-occurring HIV infection and cocaine dependence, HIV infection only, and cocaine dependence only. Participants will complete a battery of neurocognitive and behavioral measures; results will be analyzed using latent variable techniques. A subset (25 from each group, 75 total) will participate in an fMRI experiment that examines brain activity during attention and decision tasks; within and between group analyses will be conducted. This integration of behavioral and cognitive neuroscience techniques is novel and innovative, and results may help shed light on the mechanisms underlying neuropsychiatric disorders characterized by risk taking and impulsivity. This line of research has the potential to improve techniques for early identification of neurocognitive impairment and guide the development of transformative treatment approaches to improve behavioral and clinical outcomes in this population. Moreover, as a clinician, Dr. Meade will be uniquely poised to translate these findings into clinical practice. In sum, the proposed K23 award will provide the advanced training and mentored research necessary for Dr. Meade to become a nationally recognized expert in the neuropsychiatry of drug abuse and HIV/AIDS and to conduct transdisciplinary research in this evolving field. PUBLIC HEALTH RELEVANCE: Over 1 million Americans are living with HIV/AIDS, with approximately 56,000 new infections each year in the United States. Stimulant abuse, primarily cocaine and methamphetamine, is common among HIV-infected adults and is associated with continued sexual risk taking, poor treatment adherence, and other risky behaviors. A better understanding of the underlying mechanisms associated with neurobehavioral dysfunction in HIV-infected drug abusers may guide the development of innovative prevention and treatment approaches.
描述(由申请人提供): HIV 感染和可卡因依赖的神经行为和功能磁共振成像研究 Christina Meade 博士的长期目标是建立一个独立且富有成效的以患者为导向的研究计划,致力于了解药物滥用对行为和临床的影响艾滋病毒/艾滋病感染者或有感染风险的人的结果。该应用程序提出了专注于艾滋病毒神经行为功能障碍的综合培训和研究计划。指导性假设是,与每种疾病独立相比,同时发生的艾滋病毒感染和可卡因依赖与更大的神经认知障碍和行为风险相关。随着艾滋病毒/艾滋病和药物滥用领域的发展,跨学科研究有可能加速这些神经精神疾病的预防和治疗进展。因此,米德博士是一位持有执照的临床心理学家,在艾滋病毒/艾滋病和药物滥用方面拥有深厚的行为科学背景,旨在发展认知神经科学方面的专业知识。具体来说,她寻求以下方面的高级培训:(1) 神经艾滋病和神经认知评估; (2)功能磁共振成像(fMRI); (3)与成瘾和神经艾滋病相关的脑回路; (4)重复测量和潜在变量的纵向数据分析。培训计划包括教学课程和研讨会、一对一指导、参加工作组和研讨会以及出席国内和国际会议。与拟议研究的跨学科性质相一致,我们组建了一个具有独特但互补的专业领域的导师团队:博士。 Scott Huettel(功能磁共振成像和执行功能)、Kevin Robertson(神经艾滋病和神经心理学)、Joseph McClernon(成瘾和神经影像学)、Kathleen Sikkema(艾滋病毒行为方面)、Rick Hoyle(统计学和方法论)和 Roger Weiss(药物成瘾)。杜克大学提供了一个丰富的环境,使米德博士可以轻松实现职业发展目标,包括使用最先进的神经影像设施、支持以患者为导向的研究的临床单位、功能磁共振成像、统计学、和神经生物学,以及几个直接相关的跨学科研究中心和研究所。研究计划经过精心设计,与培训计划并行;对于每个培训目标都有一个相应的研究指令,使米德博士能够实施新开发的技能。 HIV 感染和兴奋剂滥用都会影响神经认知功能,但很少有研究实证检验同时发生的 HIV 感染和兴奋剂滥用对神经行为结果的影响。这是一个重要的研究课题,因为该人群同时发生的艾滋病毒感染和兴奋剂滥用的患病率很高,而且危险和冲动行为的发生率也很高。该研究计划有2项研究,具体目标如下:(1)确定HIV感染和可卡因依赖中神经认知损伤的模式,并测试这些是否与风险决策和行为风险相关; (2) 检查与注意力和决策相关的大脑激活模式,作为 HIV 疾病进展的函数,以及同时发生与独立的 HIV 感染和可卡因依赖的关系。将招募 160 名患者作为样本,对同时发生 HIV 感染和可卡因依赖、仅 HIV 感染和仅可卡因依赖的患者进行 3 组比较研究。参与者将完成一系列神经认知和行为测量;将使用潜变量技术对结果进行分析。一个子集(每组 25 人,总共 75 人)将参加功能磁共振成像实验,该实验检查注意力和决策任务期间的大脑活动;将进行组内和组间分析。这种行为和认知神经科学技术的整合是新颖和创新的,其结果可能有助于揭示以冒险和冲动为特征的神经精神疾病的潜在机制。这一系列研究有可能改进早期识别神经认知障碍的技术,并指导变革性治疗方法的开发,以改善该人群的行为和临床结果。此外,作为一名临床医生,米德博士将有独特的能力将这些发现转化为临床实践。总之,拟议的 K23 奖项将为 Meade 博士提供必要的高级培训和指导研究,使他成为药物滥用和艾滋病毒/艾滋病神经精神病学领域全国公认的专家,并在这个不断发展的领域进行跨学科研究。 公共卫生相关性:超过 100 万美国人感染艾滋病毒/艾滋病,美国每年新增约 56,000 例感染者。兴奋剂滥用(主要是可卡因和甲基苯丙胺)在艾滋病毒感染成年人中很常见,并且与持续的性冒险、治疗依从性差和其他危险行为有关。更好地了解艾滋病毒感染者的神经行为功能障碍相关的潜在机制可能会指导创新预防和治疗方法的开发。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CHRISTINA S MEADE其他文献
CHRISTINA S MEADE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CHRISTINA S MEADE', 18)}}的其他基金
Modeling the effects of chronic marijuana use on neuroinflammation and HIV-related neuronal injury
模拟长期吸食大麻对神经炎症和 HIV 相关神经元损伤的影响
- 批准号:
10459575 - 财政年份:2020
- 资助金额:
$ 1.39万 - 项目类别:
Modeling the effects of chronic marijuana use on neuroinflammation and HIV-related neuronal injury
模拟长期吸食大麻对神经炎症和 HIV 相关神经元损伤的影响
- 批准号:
10890228 - 财政年份:2020
- 资助金额:
$ 1.39万 - 项目类别:
Modeling the effects of chronic marijuana use on neuroinflammation and HIV-related neuronal injury
模拟长期吸食大麻对神经炎症和 HIV 相关神经元损伤的影响
- 批准号:
10267730 - 财政年份:2020
- 资助金额:
$ 1.39万 - 项目类别:
Role of cannabis on HIV-related cognitive impairment: a brain connectomics study
大麻对艾滋病毒相关认知障碍的作用:脑连接组学研究
- 批准号:
10596463 - 财政年份:2018
- 资助金额:
$ 1.39万 - 项目类别:
MRI data fusion to investigate effects of drug abuse on HIV neurological complications
MRI 数据融合研究药物滥用对 HIV 神经并发症的影响
- 批准号:
10347306 - 财政年份:2018
- 资助金额:
$ 1.39万 - 项目类别:
Role of cannabis on HIV-related cognitive impairment: a brain connectomics study
大麻对艾滋病毒相关认知障碍的作用:脑连接组学研究
- 批准号:
9903280 - 财政年份:2018
- 资助金额:
$ 1.39万 - 项目类别:
MRI data fusion to investigate effects of drug abuse on HIV neurological complications
MRI 数据融合研究药物滥用对 HIV 神经并发症的影响
- 批准号:
10890227 - 财政年份:2018
- 资助金额:
$ 1.39万 - 项目类别:
Role of cannabis on HIV-related cognitive impairment: a brain connectomics study
大麻对艾滋病毒相关认知障碍的作用:脑连接组学研究
- 批准号:
10890226 - 财政年份:2018
- 资助金额:
$ 1.39万 - 项目类别:
A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation
HIV 相关神经认知障碍的系统生物学方法:药物滥用和神经炎症的作用
- 批准号:
9977138 - 财政年份:2016
- 资助金额:
$ 1.39万 - 项目类别:
Cognitive Training to Reduce Impulsivity in HIV-infected Cocaine Users
认知训练可减少感染艾滋病毒的可卡因使用者的冲动
- 批准号:
9198077 - 财政年份:2016
- 资助金额:
$ 1.39万 - 项目类别:
相似海外基金
Cooperative mechanisms of HIV and opiods in pain pathogenisis
HIV和阿片类药物在疼痛发病机制中的合作机制
- 批准号:
10461002 - 财政年份:2021
- 资助金额:
$ 1.39万 - 项目类别:
Cooperative mechanisms of HIV and opiods in pain pathogenisis
HIV和阿片类药物在疼痛发病机制中的合作机制
- 批准号:
10017022 - 财政年份:2019
- 资助金额:
$ 1.39万 - 项目类别:
Cooperative mechanisms of HIV and opiods in pain pathogenisis
HIV和阿片类药物在疼痛发病机制中的合作机制
- 批准号:
9927395 - 财政年份:2019
- 资助金额:
$ 1.39万 - 项目类别:
Cooperative mechanisms of HIV and opiods in pain pathogenisis
HIV和阿片类药物在疼痛发病机制中的合作机制
- 批准号:
10224162 - 财政年份:2019
- 资助金额:
$ 1.39万 - 项目类别:
Biomarkers of Blood Brain Barrier Injury in Methamphetamine Use and HIV Disease
甲基苯丙胺使用和艾滋病毒疾病中血脑屏障损伤的生物标志物
- 批准号:
8730973 - 财政年份:2014
- 资助金额:
$ 1.39万 - 项目类别: