LONGITUDINAL STUDY OF ACUTE OTITIS MEDIA (AOM) DEVELOPMENT IN CHILDREN WITH

儿童急性中耳炎 (AOM) 发展的纵向研究

• 批准号: 7605386
• 负责人: Tasnee Chonmaitree
• 金额: $ 5.09万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605386
• 关键词: Acute; Alleles; Child; Childhood; Complex; Complication; Computer Retrieval of Information on Scientific Projects Database; Cytokine Gene; Development; Disease; Etiology; Funding; Gene Expression Regulation; Genetic; Genetic Polymorphism; Genotype; Grant; In Vitro; Infant; Institution; Interleukin-6; Longitudinal Studies; Microbe; Monitor; Otitis Media; Pathogenicity; Phase; Research; Research Personnel; Resources; Risk; Role; Source; United States National Institutes of Health; Upper Respiratory Infections; Viral; Virus; Week; cytokine; in vivo; respiratory; respiratory virus; virus development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Otitis media (OM), the most common pediatric disease, is recognized to be multifactorial, with complex genetic, environmental and infectious etiologies. Acute otitis media (AOM) usually occurs as a bacterial complication of viral upper respiratory tract infection (URI) in children. Evidence suggests that different types of viruses vary in their ability to induce AOM. The proposed study will investigate the relationship between "host" and "microbe" in the development of virus-induced AOM. We will explore the pathogenicity of specific respiratory viruses, and the role of proinflammatory cytokines (TNFa, IL-1b, IL-6) and their gene regulation in the mechanisms of virus-induced AOM. We will study differential cytokine expression in virus-induced AOM in vivo and in vitro. We will prospectively follow 210 infants and children, with and without polymorphisms of acute phase cytokine genes (TNFa-308, IL-1b+3953, and IL- 6-174 alleles) for one year. For 3 weeks after each viral URI episode, we will monitor for the occurrence of AOM. We will compare virus type and cytokine concentrations in respiratory secretions from children who do and who do not develop AOM as a complication. Risk for AOM development will be evaluated for association with cytokine genotypes. The study will help clarify the role of specific respiratory viruses, proinflammatory cytokines, and their gene regulation in the pathogenetic mechanisms of virus-induced AOM.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 中耳炎（OM）是最常见的小儿疾病，被认为是多因素，具有复杂的遗传，环境和感染性病因。急性中耳炎（AOM）通常是儿童病毒上呼吸道感染（URI）的细菌并发症。证据表明，不同类型的病毒诱导AOM的能力有所不同。拟议的研究将研究“宿主”和“微生物”在病毒诱导的AOM发展中的关系。我们将探讨特定呼吸道病毒的致病性，以及促炎细胞因子（TNFA，IL-1B，IL-6）的作用及其基因调节在病毒诱导的AOM机理中。我们将研究病毒诱导的体内和体外的AOM的差异细胞因子表达。我们将前瞻性地跟随210名婴儿和儿童，有和没有急性相细胞因子基因（TNFA-308，IL-1B+3953和IL-6-174等位基因）的多态性。每次病毒URI发作后的3周，我们将监视AOM的发生。我们将在呼吸道分泌物中比较病毒类型和细胞因子浓度，这些儿童的呼吸道分泌物和不形成AOM作为并发症的儿童。将评估AOM发育的风险与细胞因子基因型关联。该研究将有助于阐明特定呼吸道病毒，促炎细胞因子及其基因调节在病毒诱导的AOM的致病机制中的作用。