PATHOGENESIS OF VIRUS-INDUCED ACUTE OTITIS MEDIA: GENETIC AND ENVIRONMENTAL

病毒引起的急性中耳炎的发病机制：遗传和环境

• 批准号: 7952168
• 负责人: Tasnee Chonmaitree
• 金额: $ 0.21万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952168
• 关键词: 1 year old; Acute; Birth; Child; Childhood; Clinical Research; Complex; Complication; Computer Retrieval of Information on Scientific Projects Database; Disease; Enrollment; Environmental Risk Factor; Etiology; Funding; Gender; Genes; Genetic; Genetic Polymorphism; Genetic Predisposition to Disease; Grant; Incidence; Infant; Institution; Life; Living Wills; Longitudinal Studies; Monitor; Otitis Media; Public Health; Race; Research; Research Personnel; Resources; Risk; Source; TNF gene; United States National Institutes of Health; Update; Viral; Work; design; genetic risk factor; innovation; prevent; prospective; virus pathogenesis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Otitis media (OM) is the most common disease seen in pediatric practice and is recognized as a multifactorial disease with complex and interrelated genetic, environmental and infectious etiologies. We will study the mechanisms by which genetic risk factors (as represented by TNF -308 and IL- 6-174 polymorphisms) render the host OM susceptible and whether environmental factors could modify OM risks in children with genetic predisposition. We will perform a prospective, longitudinal study of 300 infants with and without TNF -308 polymorphism followed from near birth to the first AOM episode up to 1 year of age. Subjects will be screened for the gene polymorphism; equal number of polymorphic and normal infants (matched for gender and race) will be enrolled into the study within the first month of life. The dynamics of nasopharyngeal bacterial colonization in the first 6 mos. of life will be studied; symptomatic URI episodes will be monitored for AOM complication. Information on BF, CSE, and daycare (DC) attendance will be collected prospectively and updated continuously. Incidence of AOM in the first year of life (% of cases with at least one episode in the first year) will be compared between polymorphic and normal children groups; modifying effects of environmental risk factors on bacterial colonization, incidence of viral URI and AOM will be assessed. We will also compare IL- 6-174 polymorphic and normal children. The study is important to public health as it will lay the ground work for the design of innovative approaches to prevent OM.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 中耳炎 (OM) 是儿科实践中最常见的疾病，被认为是一种多因素疾病，具有复杂且相互关联的遗传、环境和感染病因。我们将研究遗传风险因素（以 TNF -308 和 IL-6-174 多态性为代表）使宿主 OM 易感的机制，以及环境因素是否可以改变具有遗传倾向的儿童的 OM 风险。我们将对 300 名有或没有 TNF -308 多态性的婴儿进行一项前瞻性、纵向研究，研究范围为从出生前到第一次 AOM 发作直至 1 岁。对受试者进行基因多态性筛查；同等数量的多态性婴儿和正常婴儿（性别和种族相匹配）将在出生后第一个月内被纳入研究。前 6 个月内鼻咽部细菌定植动态。将研究生活的内容；将监测有症状的 URI 发作是否有 AOM 并发症。有关 BF、CSE 和日托 (DC) 出勤的信息将前瞻性收集并持续更新。将在多态性儿童组和正常儿童组之间比较出生后第一年 AOM 的发病率（第一年至少发作一次的病例百分比）；将评估环境风险因素对细菌定植、病毒 URI 和 AOM 发生率的影响。我们还将比较 IL-6-174 多态性儿童和正常儿童。这项研究对公共卫生很重要，因为它将为设计预防 OM 的创新方法奠定基础。