Oral HPV Infection Among HIV+/HIV- Male Drug Users in Puerto Rico

波多黎各 HIV/HIV 男性吸毒者的口腔 HPV 感染

基本信息

批准号：
8280336
负责人：
Vivian Colon
金额：
$ 15万
依托单位：
UNIVERSITY OF PUERTO RICO MED SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8280336
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Affect Age Anogenital Human Papilloma Virus Infection Anus Area Award Behavioral Biological Chronic Clinic Clinical Research Collaborations Commit Comorbidity Crack Cocaine DNA DNA laboratory Data Data Analyses Detection Development Diagnosis Disease Drug abuse Drug usage Drug user Epidemic Epidemiologic Studies Epidemiology Exposure to Foundations Funding Funding Mechanisms Future General Population Genital system Genotype HIV HIV Infections HIV Seropositivity Heroin Heterosexuals High Prevalence Hispanics Human Papilloma Virus Vaccine Human Papillomavirus Human papilloma virus infection Immunologic Surveillance Incidence Individual Infection Infectious Disease Epidemiology Injection of therapeutic agent Investigation Island Knowledge Laboratories Life Life Expectancy Malignant Neoplasms Malignant neoplasm of anus Malignant neoplasm of penis Marijuana Methodology Molecular Epidemiology National Institute of Drug Abuse Neoplasms Oncogenic Viruses Oral Oral cavity Parents Participant Peer Review Persons Pharmaceutical Preparations Population Preparation Prevalence Primary Prevention Publications Puerto Rican Puerto Rico Research Research Personnel Risk Risk Behaviors Risk Factors Risk Reduction Sampling Science Scientist Screening procedure Sex Behavior Sexually Transmitted Diseases Social Network Specimen Testing Time Tobacco use Underserved Population United States Unsafe Sex Ursidae Family Vaccines Viral Virus Vulnerable Populations aged antiretroviral therapy base cancer risk cancer type carcinogenesis career high risk high risk men high risk sexual behavior male malignant mouth neoplasm malignant oropharynx neoplasm men mortality penis sex surveillance data transmission process

项目摘要

DESCRIPTION (provided by applicant): Recent studies have highlighted the significance of co-morbid STIs among HIV+ individuals but few have described their impact in chronic long-term sequelae, particularly among drug users, where primary prevention efforts might be delayed and screening practices might be nonexistent. Human papillomavirus (HPV), one of the most commonly diagnosed STIs world-wide, is of particular concern among persons living with HIV, due to the virus's oncogenic potential and the synergy of HPV infection and neoplasias with HIV coinfections. In men, not only is HPV infection associated with oral, penile and anal cancer, this risk is higher in HIV+ individuals as compared to the general population. Despite reductions in well known risk factors for oral cancers such as tobacco consumption, an augmented incidence of HPV-associated oropharyngeal cancers has been observed in the United States (US) and Puerto Rico (PR) and has been identified as an emerging viral epidemic of cancer. Using data from Dr. Col¿n-Lopez's NIDA funded study; this study will analyze oral biological specimens and conduct statistical analysis to describe the epidemiological profile of oral HPV infection among male drug users. Specific aims of this study are to: (1) describe the prevalence of oral HPV infection and HPV DNA genotype distribution in an existing sample collected among a clinic-based sample of HIV+/HIV- men 16-65 years in PR; (2) identify factors associated with increased odds of oral HPV infection, including age, HIV status and mode of drug use (IDU/non-IDU) administration; and (3) describe the relationship between prevalent oral and anogenital HPV infection. This application addresses the objectives of the AIDS-Science Track Award for Research Transition (A-START) by 1) supporting a new researcher; 2) serve as a foundation for expanding research to study the intersection of drug abuse, HIV/AIDS and related comorbidities. In addition, the proposed study will characterize the epidemiology of vaccine-preventable diseases and will move research scientists into discussion and development of epidemiological and clinical studies. Also, this opportunity will provide data necessary for future R01-level studies which will further evaluate the potential impact of the HPV vaccine in a reduction of oral HPV infection and subsequent HPV-related cancer risk reduction among men who are HIV+ and also men at high- risk for HIV infection.

描述（由申请人提供）：最近的研究强调了 HIV+ 个体中共病性传播感染的重要性，但很少有研究描述其对慢性长期后遗症的影响，特别是在吸毒者中，初级预防工作可能会被推迟，筛查实践可能会被推迟。人乳头瘤病毒 (HPV) 是全世界最常诊断的性传播感染之一，由于该病毒具有致癌潜力以及 HPV 感染和病毒的协同作用，因此受到 HIV 感染者的特别关注。在男性中，HPV 感染不仅与口腔癌、阴茎癌和肛门癌有关，而且与一般人群相比，尽管吸烟等众所周知的口腔癌危险因素有所减少，但 HIV 阳性个体的这种风险更高。，在美国 (US) 和波多黎各 (PR) 观察到 HPV 相关口咽癌的发病率增加，并根据 Col¿ 博士的数据被确定为一种新出现的病毒性癌症流行病。 n-Lopez 的 NIDA 资助研究；本研究将分析口腔生物标本并进行统计分析，以描述男性吸毒者中口腔 HPV 感染的流行病学概况。本研究的具体目的是：（1）描述口腔 HPV 感染的流行情况。以及在 16-65 岁 PR 的 HIV+/HIV- 男性临床样本中收集的现有样本中的 HPV DNA 基因型分布 (2) 确定与口腔 HPV 感染几率增加相关的因素，包括年龄、HIV 状况和药物使用方式（注射吸毒者/非注射吸毒者）管理；以及 (3) 描述流行的口腔和肛门生殖器 HPV 感染之间的关系。该申请通过 1 解决了艾滋病科学轨道研究转变奖 (A-START) 的目标。 ) 支持新的研究人员；2) 为扩大研究药物滥用、艾滋病毒/艾滋病和相关合并症的交叉点奠定基础。此外，拟议的研究将描述疫苗可预防疾病的流行病学特征，并将推动相关研究的发展。此外，这一机会将为未来的 R01 水平研究提供必要的数据，进一步评估 HPV 疫苗在减少口腔 HPV 感染和随后的 HPV 相关癌症方面的潜在影响。降低艾滋病毒阳性男性和艾滋病毒感染高危男性的风险。