HPV Infection Among High-Risk Young Men in Puerto Rico

波多黎各高危年轻男性 HPV 感染

基本信息

批准号：
7928054
负责人：
Vivian Colon
金额：
$ 3.71万
依托单位：
UNIVERSITY OF PUERTO RICO MED SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-15 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7928054
关键词：
4 year old Accounting Adolescent Age Age-Years American Anogenital Human Papilloma Virus Infection Anus Attention Behavioral Biological Biological Testing Cervical Squamous Cell Carcinoma Chronic Disease Client Clinic Clinical Clinical assessments Collaborations Communities Data Development Diagnosis Drug usage Drug user Epidemiologic Studies Epidemiology Female Foundations Funding Funding Mechanisms Future Genetic Genital Human Papilloma Virus Infection Genotype HIV HIV Infections Health Health Services Accessibility Human Papilloma Virus Vaccine Human Papillomavirus Human papilloma virus infection Incidence Individual Infection Infection prevention Injection of therapeutic agent Island Knowledge Link Malignant Neoplasms Malignant neoplasm of vulva Medical Mental Health Methodology Minority Groups Molecular Molecular Epidemiology Oral cavity Outcome Pattern Pharmaceutical Preparations Pharyngeal structure Pilot Projects Population Population Group Prevalence Prevention Prevention program Public Health Schools Puerto Rico Recruitment Activity Research Research Personnel Resources Risk Risk Factors Role Sampling Science Screening procedure Sexual Partners Sexually Transmitted Diseases Source Symptoms Training Universities Ursidae Family Vaccination Vaccines Vagina Vulnerable Populations Woman Youth addiction base cohort cost global health health literacy high risk high risk men male men penis prophylactic public health relevance research and development sexually active skills social standard of care transmission process trend young adult

项目摘要

Genital HPV infection is one of the most commonly diagnosed STIs worldwide and its high prevalence may also contribute to increased HIV transmission risk. Although HPV infection has been causally linked with chronic disease sequelae both in men and women, relatively little is known about the distribution of HPV infection and HPV subtypes among in relation to HIV status. Understanding the prevalence, distribution, and general sources of HPV subtypes among both HIV+ and HIV- individuals is important for understanding long term health consequences of HPV. Researchers within the Center for Research on Global Health at the School of Public Health, Medical Sciences Campus, Puerto Rico, in collaboration with the largest publicly funded STI clinic on the island (Centro Latinoamericano de Enfermedades de Transmisi¿n Sexual (CLETS)), are conducting an assessment of drug and sexual risk among sexually active, young male drug users. Using an ethnoepidemiological approach that integrates behavioral research and molecular epidemiology, with the study has the following research objectives: 1. Prevalence: To compare the prevalence of anogenital HPV infection in a clinic-based sample of HIV+ and HIV- young male drug users in Puerto Rico. 2. Genotype Variability: To compare the distribution of HPV subtypes in a clinicbased sample of HIV+ and HIV- young male drug users in Puerto Rico. 3. Sexual Risk Factors: To compare HIV+ and HIV- young male drug users, with particular attention to sexual risk practices (e.g., sexual practices, sex partnering) that may be associated with HPV subtypes and/or HIV/HPV coinfection.

生殖器 HPV 感染是全世界最常诊断的性传播感染之一，其尽管 HPV 感染率较高，但也可能导致 HIV 传播风险增加。感染与男性和女性的慢性疾病后遗症有因果关系女性，对于 HPV 感染的分布和 HPV 知之甚少亚型与艾滋病毒状况的关系。 HIV+ 和 HIV- 个体中 HPV 亚型的一般来源是对于研究人员了解 HPV 的长期健康影响非常重要。公共卫生、医学院全球健康研究中心波多黎各科学园区与最大的公共资助 STI 合作岛上的诊所（Centro Latinoamericano de Enfermedades de Transmisi¿n Sexual （CLETS）），正在对性活跃的人进行毒品和性风险评估，年轻男性吸毒者采用民族流行病学方法。行为研究和分子流行病学，研究有以下内容研究目标： 1. 患病率：比较肛门生殖器 HPV 的患病率波多黎各 HIV+ 和 HIV- 年轻男性吸毒者临床样本中的感染情况 Rico。2. 基因型变异性：比较临床中 HPV 亚型的分布。波多黎各 HIV+ 和 HIV- 年轻男性吸毒者样本 3. 性风险。因素：比较 HIV+ 和 HIV- 年轻男性吸毒者，特别关注可能与以下行为有关的性风险行为（例如性行为、性伴侣） HPV 亚型和/或 HIV/HPV 合并感染。