Environmentally Triggered Neurodevelopmental Disorders: Focus on Endocrine Disrup

环境引发的神经发育障碍：关注内分泌紊乱

• 批准号: 8402883
• 负责人: Joan Marie Cranmer
• 金额: $ 0.3万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2012-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8402883
• 关键词: Address; Androgens; Animals; Arkansas; Attention deficit hyperactivity disorder; Autistic Disorder; Award; Awareness; Basic Science; Central Nervous System Diseases; Chemicals; Child; Clinical; Clinical Research; Collaborations; Communication; Communities; Complex; Copy Number Polymorphism; Data; Diagnosis; Diagnostic; Disease; Educational workshop; Endocrine; Endocrine Disruptors; Endocrine disruption; Endocrine system; Environment; Environmental Health; Environmental Risk Factor; Epidemiologist; Epidemiology; Epilepsy; Estrogens; Event; Experimental Designs; Exposure to; Fingers; Food; Fostering; Gene Mutation; Genetic Polymorphism; Goals; High Prevalence; Hormones; Human; Human Milk; Immune; Impairment; Interdisciplinary Study; International; Intervention; Investigation; Journals; Link; Mediating; Medical; Medicine; Mentors; Metals; Methods; Neurodevelopmental Disorder; Nutritional status; Paper; Participant; Peer Review; Postdoctoral Fellow; Predisposition; Prevalence; Public Health; Publications; Published Comment; Publishing; Research; Research Personnel; Risk; Risk Assessment; Risk Factors; Role; Schizophrenia; Science; Scientist; Series; Sex Bias; Sex Characteristics; Signal Transduction; Structure; Students; Symptoms; Thinking; Thyroid Gland; Time; Tissues; Touch sensation; Universities; Work; Xenobiotics; abstracting; boys; clinically significant; college; critical period; design; environmental stressor; indexing; interdisciplinary collaboration; male; meetings; multidisciplinary; neonate; nervous system disorder; neurodevelopment; neurotoxicology; novel; novel strategies; pediatric department; policy implication; pollutant; posters; pre-doctoral; professor; programs; public health relevance; social; social implication; special interest group; symposium; trend

DESCRIPTION (provided by applicant) The 27th meeting in the International Neurotoxicology Conference Series (NEUROTOX 27) will address the theme of "Environmentally Triggered Neurodevelopmental Disorders: Focus on Endocrine Disruption and Sex Differences in Autism, ADHD, and Schizophrenia". NEUROTOX 27 will convene October 30 to November 2, 2011 at the Sheraton Imperial Hotel and Conference Center in Research Triangle Park, NC. Each conference in the series is devoted to a timely, forward-thinking theme that has significant impact on environmental health and neurological disorders, and there exists enough evidence that the science on the theme will be advanced by being scrutinized in this established, multidisciplinary, focused, program approach. To be at the forefront of science the conference chair partners with internationally-recognized scientific experts on the focused theme to co-organize the meeting and identify the session themes, topics and speakers. This year the meeting will be highly focused on two endpoints: 1) endocrine disruption and 2) sex differences, in three complex neurodevelopmental disorders which have factors in common: 1) autism, 2) ADHD and 3) schizophrenia. The plenary sessions have been structured to present the latest clinical and basic research in a format that will facilitate discussion, address specific questions (published in the Program) and be conducive to a cross-cutting discussion on common factors on the last day of the conference after evidence has been presented. Significance: Clinical disorders of the central nervous system arise from complex interactions among multiple risk factors. Genetic mutations, polymorphisms, and copy number variations confer heritable susceptibility to environmental stressors including exposures to xenobiotic chemicals, shifts in nutritional status, and medical interventions. The prevalence of autism has increased dramatically and there is emerging evidence that suggests increases in the diagnosis of ADHD and schizophrenia. Although some of these trends can be explained by increased awareness, diagnostic drift and changes in diagnostic criteria, environmental factors are likely contributors. An increasing number of persistent organic pollutants (POPs) and metals have been shown to alter endocrine signaling mediated by thyroid, estrogen and androgen hormones. Many of these chemicals are detected in maternal and gestational tissues, breast milk, and neonates at levels of concern. The consequences of endocrine disruption during critical periods of neurodevelopment have far-reaching implications. NEUROTOX 27 will present the latest evidence and controversies linking endocrine disruption and neurodevelopmental disorders, with a focus on autism, ADHD, and schizophrenia. These 3 disorders share several clinical features including strong gender bias, immune impairments, and an association with seizure disorders. Yet these disorders differ in onset of clinical symptoms that may provide clues to critical windows of susceptibility to specific endocrine disruptors and their underlying mechanisms. The conference is designed to present attendees with the latest state-of-the-science about the role of the endocrine system in environmentally triggered disorders and stimulate vigorous discussion among experts from different backgrounds to help advance the science related to the theme. Public Health Relevance: The public health relatedness of this application is that the results of this conference will help us better understand the role of the environment, endocrine disruption, and sex differences in autism, ADHD and schizophrenia. NEUROTOXICOLOGY 27 will convene internationally recognized experts to present the latest evidence and controversies linking endocrine disruption and environmentally triggered neurodevelopmental disorders, with a focus on autism, ADHD, and schizophrenia. The public health impact of these disorders is enormous. Today, one in 110 children (and one in 70 boys) born in the U.S. is diagnosed with autism, and the numbers have been rising 10% to 17% a year. Autism has a range of features that suggest the possibility of endocrine-related alterations, including a much higher prevalence in males. Other clinical clues invite critical investigation of potential toxicological, immune and endocrine disruptive contributors to autism, ADHD and schizophrenia. Peer-reviewed papers from NEUROTOXICOLOGY 27 will be published rapidly, disseminated internationally, and made accessible online to readily reach target audiences.

描述（由申请人提供） 国际神经毒理学会议系列（NEUROTOX 27）第27次会议的主题是“环境引发的神经发育障碍：关注自闭症、多动症和精神分裂症的内分泌干扰和性别差异”。 NEUROTOX 27 将于 2011 年 10 月 30 日至 11 月 2 日在北卡罗来纳州研究三角园的喜来登帝国酒店和会议中心召开。 该系列中的每一次会议都致力于一个及时的、前瞻性的主题，该主题对环境健康和神经系统疾病有重大影响，并且有足够的证据表明，通过在这个既定的、多学科的、重点关注的会议中进行审查，有关该主题的科学将得到推进。 ，程序方法。为了走在科学的最前沿，会议主席与国际公认的科学专家就重点主题合作，共同组织会议并确定会议主题、议题和发言人。今年的会议将高度关注三个复杂的神经发育障碍的两个终点：1）内分泌干扰和2）性别差异，这些障碍具有共同的因素：1）自闭症，2）多动症和3）精神分裂症。全体会议的结构是为了介绍最新的临床和基础研究，其形式将促进讨论、解决具体问题（在计划中发布）并有利于在会议最后一天就共同因素进行跨领域讨论证据出示后。 意义：中枢神经系统的临床疾病是由多种危险因素之间复杂的相互作用引起的。 基因突变、多态性和拷贝数变异导致对环境压力因素的遗传易感性，包括接触外源化学物质、营养状况的变化和医疗干预。自闭症的患病率急剧上升，并且有新的证据表明多动症和精神分裂症的诊断率有所增加。尽管其中一些趋势可以通过认识的提高、诊断漂移和诊断标准的变化来解释，但环境因素可能是促成因素。 越来越多的持久性有机污染物 (POP) 和金属已被证明会改变甲状腺、雌激素和雄激素介导的内分泌信号。 其中许多化学物质在母体和妊娠组织、母乳和新生儿中检测到，其浓度令人担忧。神经发育关键时期内分泌干扰的后果具有深远的影响。 NEUROTOX 27 将展示内分泌干扰和神经发育障碍之间的最新证据和争议，重点关注自闭症、多动症和精神分裂症。这 3 种疾病具有一些共同的临床特征，包括强烈的性别偏见、免疫损伤以及与癫痫症的相关性。然而，这些疾病在临床症状的发作上有所不同，这可能为了解特定内分泌干扰物的易感性关键窗口及其潜在机制提供线索。此次会议旨在向与会者展示有关内分泌系统在环境引发的疾病中的作用的最新科学进展，并激发来自不同背景的专家之间的激烈讨论，以帮助推进与该主题相关的科学。 公共健康相关性：该应用程序的公共健康相关性在于，本次会议的结果将帮助我们更好地了解环境、内分泌干扰以及性别差异在自闭症、多动症和精神分裂症中的作用。神经毒理学第 27 届会议将召集国际公认的专家，介绍内分泌干扰与环境引发的神经发育障碍之间的最新证据和争议，重点关注自闭症、多动症和精神分裂症。这些疾病对公共健康的影响是巨大的。如今，美国出生的每 110 名儿童（以及 70 名男孩中就有 1 名）被诊断患有自闭症，并且这一数字每年以 10% 至 17% 的速度增长。 自闭症具有一系列特征，表明可能存在与内分泌相关的改变，其中男性的患病率要高得多。其他临床线索需要对自闭症、多动症和精神分裂症的潜在毒理学、免疫和内分泌干扰因素进行严格研究。 NEUROTOXICOLOGY 27 经过同行评审的论文将迅速出版，在国际上传播，并可在线访问以方便目标受众。