The Impact of Stress and Psychosocial Factors on Inflammation in Women

压力和社会心理因素对女性炎症的影响

• 批准号: 8318589
• 负责人: SUSAN A EVERSON-ROSE
• 金额: $ 6.19万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318589
• 关键词: Address; Adipocytes; African American; Age; Aging; Ancillary Study; Anti-Inflammatory Agents; Anti-inflammatory; Anxiety; Autonomic nervous system; Behavioral; Biological Markers; Cardiovascular Diseases; Caucasians; Caucasoid Race; Cause of Death; Characteristics; Chronic stress; Critical Pathways; Data; Data Analyses; Data Set; Development; Diabetes Mellitus; Discrimination; Disease; Epidemiologic Studies; Event; Fostering; Funding; Future; Goals; Heart Diseases; Hostility; Inflammation; Inflammatory; Insulin Resistance; Knowledge; Lead; Leptin; Life; Measures; Mediating; Menopausal Status; Mental Depression; Mental Health; Metabolic; Metabolic syndrome; Modeling; National Institute of Mental Health; Nervous System Physiology; Obesity; Outcome; Parents; Participant; Pathway interactions; Prevention; Process; Psychosocial Factor; Psychosocial Stress; Public Health; Race; Regulation; Reporting; Research; Risk; Risk Factors; Sample Size; Sampling; Social support; Specimen; Stress; Testing; Time; Woman; Women' s Health; Work; adiponectin; biopsychosocial; cardiovascular disorder risk; depressive symptoms; design; disability; energy balance; experience; inflammatory marker; middle age; optimism; programs; psychologic; psychosocial; public health relevance; racial difference; repository; social

DESCRIPTION (provided by applicant): This proposal is responsive to PA-10-139 entitled, "Secondary Analyses of Social and Behavioral Datasets in Aging (R03)". The long-term goals of our research program are to examine the impact of chronic stress and psychosocial factors on metabolic dysregulation and cardiovascular disease (CVD) risk and to investigate the biologic mechanisms underlying these associations. The PI has an active study (1R21HL091290) using data from the NIA/NINR-funded Study of Women's Health across the Nation (SWAN), and the ancillary SWAN Mental Health Study, to investigate the impact of depression on adiponectin and leptin. Adiponectin is the most abundant anti-inflammatory adipocytokine secreted by adipocytes and leptin is a pro-inflammatory adipocytokine intimately involved in metabolic regulation, energy balance, and autonomic nervous system functioning. The proposed study will significantly enhance this work by expanding the breadth of psychosocial measures available to us. We propose to utilize additional existing SWAN data on multiple measures of chronic stress (financial strain, perceived stress, stressful life events, perceived discrimination) and psychosocial functioning (hostility, anxiety, optimism, social support), together with the adiponectin and leptin data from the PI's active R21, to examine both cross-sectional and 5-year longitudinal associations between stress/psychosocial factors and these critical obesity-related inflammatory markers in 581 SWAN participants (225 black women, 356 white women). Aims are: 1) to determine if chronic stress is associated with baseline and 5-year changes in adiponectin and leptin levels; and 2) to determine if psychosocial factors are associated with baseline and 5-year changes in adiponectin and leptin levels. Secondary aims are to examine pathways among the measures of stress and psychosocial functioning, including depression, and these obesity-related inflammatory markers, and to investigate potential race differences in the hypothesized associations. The project will provide crucial data that will foster development of a more comprehensive and integrative biopsychosocial framework to guide future studies and achieve the goals of our research program. By adding to a study already in progress (R21HL091290) and utilizing the richness of the existing SWAN data, the proposed study will allow a fuller characterization of psychological and social processes that may relate to important adipokine biomarkers in women. Thus, this work has the potential to greatly expand our understanding of a critical inflammatory pathway by which stress and psychosocial factors may contribute to metabolic dysregulation and CVD risk in women. Moreover, the study addresses the critical public health problems of obesity and cardiovascular disease and thus has high public health relevance.

描述（由申请人提供）：该提案对PA-10-139的响应，标题为“衰老中的社会和行为数据集的次要分析”。我们的研究计划的长期目标是研究慢性压力和社会心理因素对代谢失调和心血管疾病（CVD）风险的影响，并研究这些关联的生物学机制。 PI使用来自NIA/NINR资助的全国妇女健康研究（SWAN）和辅助SWAN心理健康研究的数据进行了积极的研究（1R21HL091290），以研究抑郁症对脂联素和瘦素的影响。脂联素是脂肪细胞和瘦素分泌的最丰富的抗炎脂肪细胞因子，是一种亲密涉及代谢调节，能量平衡和自主神经系统功能的促炎性脂肪细胞。拟议的研究将通过扩大我们可用的社会心理措施的广度来大大增强这项工作。我们建议利用其他现有的天鹅数据，以了解多种慢性压力（财务压力，感知压力，压力性生活事件，感知到的孤立性）和心理社会功能（敌意，焦虑，焦虑，乐观，社会支持）以及PI活跃的R21的脂肪蛋白和瘦素数据的重要性R21，以跨越的5年级和lept蛋白数据，从581名天鹅参与者（225名黑人妇女，356名白人妇女）的炎症标记。目的是：1）确定慢性应激是否与脂联素和瘦素水平的基线变化相关； 2）确定社会心理因素是否与脂联素和瘦素水平的基线和5年变化有关。次要目的是检查压力和社会心理功能的度量（包括抑郁症）和这些与肥胖相关的炎症标志物的途径，并研究假设的关联中的潜在种族差异。该项目将提供至关重要的数据，以促进一个更全面和综合的生物心理社会框架，以指导未来的研究并实现我们的研究计划的目标。通过添加已经进行的研究（R21HL091290）并利用现有的天鹅数据的丰富性，拟议的研究将允许对可能与女性重要的脂肪因子生物标志物有关的心理和社会过程进行更全面的特征。因此，这项工作有可能极大地扩展我们对关键炎症途径的理解，通过这种途径，压力和社会心理因素可能导致女性代谢失调和CVD风险。此外，该研究解决了肥胖和心血管疾病的关键公共卫生问题，因此具有很高的公共卫生相关性。