BIOSPECIMEN REPOSITORY

生物样本库

• 批准号: 8364967
• 负责人: LYNNAE Karen MILLAR Sauvage
• 金额: $ 25.73万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364967
• 关键词: Affect; Award; Blood; Centers of Research Excellence; Clinical; Clinical Data; Collection; Communities; DNA; Data; Disease; Enrollment; Funding; Goals; Grant; Hawaii; Interdisciplinary Study; Minority Groups; National Center for Research Resources; Neonatal; Paraffin Embedding; Pathology; Patients; Placenta; Population; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Source; Tissues; Translational Research; Umbilical Cord Blood; United States National Institutes of Health; Universities; cost; fetal; repository

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Five years ago, a BioSpecimen Repository of obstetrical and fetal samples combined with existing clinical data was established as a part of the Clinical Center of Research Excellence (CCRE) grant awarded to the University of Hawaii. Samples and maternal and neonatal data collected as a part of this core have focused on racial and ethnic minorities and diseases disproportionately affecting these populations. Data and samples stored for the 7,652 enrolled patients include gross pathology including photographs of the placentas, paraffin embedded tissue blocks of placenta, placental samples at -80 degrees, fetal (cord blood) and maternal blood, and DNA extracted from blood and placental samples. The core has been effective at collecting the samples necessary to support numerous investigators, and continues to be a resource to the University and community. As an ongoing part of the RMATRIX grant the goal is to increase the number of researchers utilizing the core and to expand capacity at the University for biosample collection and storage.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 五年前，结合现有临床数据建立了产科和胎儿样本的生物样本存储库，作为授予夏威夷大学的卓越临床研究中心 (CCRE) 拨款的一部分。作为该核心的一部分收集的样本以及孕产妇和新生儿数据主要集中在少数种族和族裔以及对这些人群影响不成比例的疾病。为 7,652 名入组患者存储的数据和样本包括大体病理学，包括胎盘照片、石蜡包埋的胎盘组织块、-80 度胎盘样本、胎儿（脐带血）和母血，以及从血液和胎盘样本中提取的 DNA。 该核心有效地收集了支持众多研究人员所需的样本，并继续成为大学和社区的资源。作为 RMATRIX 资助的持续部分，其目标是增加利用该核心的研究人员数量，并扩大大学生物样本收集和存储的能力。