Novel Accelerated Contrast-Enhanced High Resolution Coronary MRI

新型加速对比增强高分辨率冠状动脉 MRI

基本信息

批准号：
8471770
负责人：
Mehmet Akcakaya
金额：
$ 10.2万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2014-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Coronary artery disease (CAD) is the leading cause of death in the United States, even though significant efforts have been made in prevention and diagnosis. The clinical gold standard for diagnosis of CAD is catheter-based invasive x-ray angiography, performed more than a million times per year. Of these examinations, up to 35% have been found to have no significant stenosis, yet these patients had to go through the potential risks and complications of an invasive test that further exposes the patient to ionizing radiation and iodinated contrast. Thus, non-invasive diagnostic alternatives are highly desirable. Cardiac MRI (CMR) provides a method for comprehensive non-invasive cardiac exam, including contractile functional assessment (cine CMR) to detect wall-motion abnormality, myocardial CMR perfusion for diagnosing perfusion defects, viability assessment using late gadolinium enhancement (LGE) for evaluation of acute and chronic myocardial infarction, and coronary MRI for the identification of stenosis. CMR is advantageous in several respects, since it does not require ionizing radiation or iodinated contrast, thereby facilitating repeated or follow-up scanning. However, long data acquisition time remains as one of its main limitations. Several approaches have been studied to facilitate rapid CMR acquisition. Nonetheless, the acquisition time for high-resolution CMR remains long, and spatial and temporal resolution is traded off for acquisition time in cine and perfusion imaging. Therefore, developments of methods to reduce data acquisition time beyond what is available now are appealing. We will develop novel reconstruction methodologies for high-resolution CMR that learn the anatomical structures in the images being reconstructed. We will validate these techniques in a range of contrast-enhanced CMR imaging protocols, providing better volumetric coverage of the heart, efficient use of the contrast agents, and higher spatial and temporal resolution.

描述（由申请人提供）：冠状动脉疾病（CAD）是美国死亡的主要原因，即使在预防和诊断方面已做出了重大努力。 CAD诊断的临床黄金标准是基于导管的侵入性X射线血管造影，每年进行一百万次。在这些检查中，已发现多达35％的人没有明显的狭窄，但是这些患者必须经历侵入性测试的潜在风险和并发症，这进一步使患者暴露于电离辐射和碘化对比度。因此，非常需要非侵入性诊断替代方法。心脏MRI（CMR）提供了一种全面的非侵入性心脏检查的方法，包括收缩功能评估（CINE CMR）检测壁动作异常，心肌CMR灌注，用于诊断灌注缺损的灌注，用于使用GADORIAM ENDICERAIN和CORCHAIGION MYOCAIRIAL MRINIVIAL MRINIVIAL MRINIVIAL和CHRONIVIAL IFFARNICRON和CHRONIVIAL MRINCORIN和CHRONIVION MRENIFIAL和CHRONIVION MRENCONITION和CHORCHAIRICAN的活力评估狭窄。 CMR在几个方面都是有利的，因为它不需要电离辐射或碘化对比度，从而促进重复或随访扫描。但是，长期数据获取时间仍然是其主要局限性之一。已经研究了几种方法，以促进CMR的快速获取。尽管如此，高分辨率CMR的采集时间仍然很长，并且在Cine和灌注成像中以空间和时间分辨率进行了换取以获取时间。因此，将数据获取时间减少到现在可用的方法的方法的发展是有吸引力的。我们将开发用于高分辨率CMR的新型重建方法，这些方法学学习了要重建的图像中的解剖结构。我们将在一系列对比度增强的CMR成像方案中验证这些技术，从而提供更好的心脏覆盖范围，对对比剂的有效使用以及更高的空间和时间分辨率。