Genomics

基因组学

• 批准号: 8540939
• 负责人: George S Watts
• 金额: $ 13.74万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8540939
• 关键词: Arizona; Cancer Center; Cancer Center Support Grant; ChIP-on-chip; Client satisfaction; Cognitive; Consultations; Custom; DNA; DNA Methylation; DNA Resequencing; Data; Diagnostic; Experimental Designs; Gene Expression Profiling; Genomics; Housing; Interview; Language; Mental Depression; Microarray Analysis; Mission; Nucleic Acids; Patients; Perinatal; Phase; Postpartum Depression; Postpartum Women; Preparation; Private Sector; Protocols documentation; Public Sector; Quality Control; Research Personnel; Research Project Grants; Reverse Transcriptase Polymerase Chain Reaction; Sampling; Scanning; Services; Site; Source; Surveys; Symptoms; Techniques; Technology; Testing; Time; Update; Woman; base; cost; depressive symptoms; experience; high throughput analysis; response; sound; time use

Estimates of antenatal and postpartum depression vary from 7% to upwards of 30% depending on criteria for depression, the type of assessment used, and the timing of the assessment. Thus, approximately 320,000 to over 1 million women each year experience symptoms of perinatal depression. Estimates of antenatal depression are harder to obtain because of the lack of appropriate diagnostic criteria. Despite this, no screener currently exists that has been developed and tested with both antenatal and postpartum women that uses concise, simple language, and a consistent response option set. The overall aim of this project is to develop a brief screener to assess depressive symptoms among antenatal and postpartum women. The proposed screener will be easier for patients to understand, will take less time, and will be more psychometrically sound than current screeners. In Phase I we will develop approximately 30 items that are specific to depression in antenatal and postpartum women. We will test these items using cognitive interviewing among a sample of 10 antenatal and 10 postpartum women in addition to 32 general depression items we have previously developed. Experts will review the results of the cognitive interviewing to develop the item pool that will be tested in Phase II. The Phase II item pool will consist of at least 20 general depression items, 10 items specific to antenatal women, and 10 items specific to postpartum women. In Phase II, 500 antenatal and 500 postpartum women (70% from private sector sites and 30% from public sector sites) will complete the EPDS (as a screener into the study), BDI-II, the PROMIS depression items, our items, and the depression module of the SCID. IRT analyses will be conducted on these data to develop a 7-9 item screener. We anticipate that approximately 5-7 of these items will be applicable to both antenatal and postpartum women and approximately 2-3 of these items will be sample specific. The developed screener will then be given to 400 women who will take the survey twice, approximately 4-7 days apart. Conclusions regarding test-retest reliability and patient satisfaction with taking the screener using different modes of technologies will be made from this study.

产前和产后抑郁症的估计从7％到30％以上 取决于抑郁症的标准，所使用的评估类型以及 评估。因此，每年约32万至100万女性 经历围产期抑郁症的症状。产前抑郁的估计是 由于缺乏适当的诊断标准，很难获得。尽管如此，不 目前存在的筛选器已经开发和测试了产前和测试 使用简洁，简单的语言和一致反应的产后女性 选项集。 该项目的总体目的是开发一个简短的筛选器来评估抑郁症 产前和产后妇女的症状。建议的筛选器将是 患者更容易理解，将花费更少的时间，并且会更加精神上 声音比当前的筛选器。 在第一阶段，我们将开发大约30个针对抑郁症的项目 产前和产后妇女。我们将使用认知访谈测试这些项目 除32个一般性外，在10个产前和10名产后妇女的样本中 我们以前开发的抑郁症。专家将审查 认知访谈以开发将在第二阶段进行测试的项目池。阶段 ii项目池将至少包含20个一般抑郁症项目，10个特定于 产前妇女和10个针对产后妇女的项目。 在第二阶段，有500个产前和500名产后妇女（私营部门的70％ 来自公共部门站点的30％将完成EPD（作为研究的筛选者）， BDI-II，Promis抑郁症，我们的项目和抑郁模块 scid。将对这些数据进行IRT分析，以开发7-9个项目筛选器。我们 预计这些项目中约有5-7个适用于产前和 产后妇女和大约2-3个项目将是特定于样本的。这 然后，开发的筛选器将被交给400名将进行调查两次的女性 相距约4-7天。关于重测可靠性和患者的结论 使用不同的技术模式来吸引筛选器的满意度 从这项研究。